Search Results - "Kotov, Stefan"

A Mechanistic Approach to Modeling Respiratory Sensitization by Mekenyan, Ovanes, Patlewicz, Grace, Kuseva, Chanita, Popova, Ioanna, Mehmed, Aycel, Kotov, Stefan, Zhechev, Teodor, Pavlov, Todor, Temelkov, Stanislav, Roberts, David W

“…Chemical respiratory sensitization is an important occupational health problem which may lead to severely incapacitated human health, yet there are currently…”
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Investigating the Relationship between in Vitro–in Vivo Genotoxicity: Derivation of Mechanistic QSAR Models for in Vivo Liver Genotoxicity and in Vivo Bone Marrow Micronucleus Formation Which Encompass Metabolism by Mekenyan, Ovanes G, Petkov, Petko I, Kotov, Stefan V, Stoeva, Stoyanka, Kamenska, Verginia B, Dimitrov, Sabcho D, Honma, Masamitsu, Hayashi, Makoto, Benigni, Romualdo, Donner, E. Maria, Patlewicz, Grace

“…Strategic testing as part of an integrated testing strategy (ITS) to maximize information and avoid the use of animals where possible is fast becoming the norm…”
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Integrated approach to testing and assessment for predicting rodent genotoxic carcinogenicity by Petkov, Petko I., Schultz, Terry W., Donner, E. Maria, Honma, Masamitsu, Morita, Takeshi, Hamada, Shuichi, Wakata, Akihiro, Mishima, Masayuki, Maniwa, Jiro, Todorov, Milen, Kaloyanova, Elena, Kotov, Stefan, Mekenyan, Ovanes G.

“…We investigated the performance of an integrated approach to testing and assessment (IATA), designed to cover different genotoxic mechanisms causing cancer and…”
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Epoxidation of alkenes in the presence of molybdenum–squarate complexes as novel catalysts by Topuzova, Mariana G., Kotov, Stefan V., Kolev, Tsonko M.

“…Several molybdenum-containing organic complexes based on 3,4-dihydroxy-3-cyclobutene-1,2-dione (squaric acid) have been synthesized and characterized by…”
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Preparation and use of novel molybdenum-containing organic complexes as catalysts in the epoxidation of cyclohexene by Kotov, Stefan V, Kolev, Tsonko M, Georgieva, Mariana G

“…Graphic Novel molybdenum-containing organic complexes based on 3,4-dihydroxy-3-cyclobutene-1,2-dione (“squaric acid”) and some organic amines have been…”
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Preparation and use of novel molybdenum-containing organic complexes as catalysts in the epoxidation of cyclohexene: II. Synthesis and applicability of molybdenum complexes based on squaric acid, 1-phenyl-1-ethanamine and 1,3-diamino-2-propanol by Kotov, Stefan V, Georgieva, Mariana G, Kolev, Tsonko M

“…Graphic Two novel molybdenum-containing organic complexes based on 3,4-dihydroxy-3-cyclobutene-1,2-dione (“squaric acid”), 1-phenyl-1-ethanamine and…”
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The Synthesis of Phosphonate Ester Containing Fluorinated Vinyl Ethers by Pedersen, Scot D, Qiu, Weiming, Qiu, Zai-Ming, Kotov, Stefan V, Burton, Donald J

“…Three novel perfluorovinyl ethers containing phosphonate ester groups, diethyl 1,1,2,2,3,3,5,6,6-nonafluoro-4-oxa-5-hexenylphosphonate, (EtO)2P(O)(CF2)3OCFCF2…”
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A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity? by Petkov, Petko I., Patlewicz, Grace, Schultz, Terry W., Honma, Masamitsu, Todorov, Milen, Kotov, Stefan, Dimitrov, Sabcho D., Donner, E. Maria, Mekenyan, Ovanes G.

“…•An in vitro–in vivo extrapolation workflow was adapted to mimic a mechanistic IATA.•Disconcordant outcomes could be mechanistically reasoned.•The IATA was…”
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Procedure for toxicological predictions based on mechanistic weight of evidences: Application to Ames mutagenicity by Petkov, Petko I., Kuseva, Chanita, Kotov, Stefan, Honma, Masamitsu, Kitazawa, Airi, Kulkarni, Sunil, Schultz, Terry W., Mekenyan, Ovanes G.

“…[Display omitted] •A workflow based on mechanistic QSAR, read-across and expert knowledge is proposed.•The workflow is applied to resolve conflicting Ames…”
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Use of Genotoxicity Information in the Development of Integrated Testing Strategies (ITS) for Skin Sensitization by Mekenyan, Ovanes, Patlewicz, Grace, Dimitrova, Gergana, Kuseva, Chanita, Todorov, Milen, Stoeva, Stoyanka, Kotov, Stefan, Donner, E Maria

“…Skin sensitization is an end point of concern for various legislation in the EU, including the seventh Amendment to the Cosmetics Directive and Registration…”
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Selective synthesis of cyclododec-2-en-1-yl ethers via palladium-catalyzed allylic substitution reaction: a kinetic study by KOLEV, Asen, MITKOVA, Magdalena, KOTOV, Stefan, BALBOLOV, Encho

“…The palladium-catalyzed reaction between isomeric cyclododec-2-en-1-yl acetates and primary aliphatic alcohols was found to result in high yields of the…”
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MetaPath: An electronic knowledge base for collating, exchanging and analyzing case studies of xenobiotic metabolism by Kolanczyk, Richard C., Schmieder, Patricia, Jones, William J., Mekenyan, Ovanes G., Chapkanov, Atanas, Temelkov, Stanislav, Kotov, Stefan, Velikova, Maria, Kamenska, Verginia, Vasilev, Krasimir, Veith, Gilman D.

“…► MetaPath compiles metabolism paths and data for regulatory assessments and modeling purposes. ► MetaPath provides data analysis tools for all data fields…”
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Spectroscopic and structural elucidation of 3,4-diaminopyridine and its hydrogentartarate salt: Crystal structure of 3,4-diaminopyridinium hydrogentartarate dihydrate by Koleva, Bojidarka B., Kolev, Tsonko, Tsanev, Tsanko, Kotov, Stefan, Mayer-Figge, Heike, Seidel, Rüdiger W., Sheldrick, William S.

“…The novel 3,4-diaminopyridinium hydrogentartarate dihydrate has been synthesized and its structure and properties elucidated in detail spectroscopically,…”
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Identification of the Structural Requirements for Mutagenicity by Incorporating Molecular Flexibility and Metabolic Activation of Chemicals I:  TA100 Model by Mekenyan, Ovanes, Dimitrov, Sabcho, Serafimova, Rossitsa, Thompson, Ed, Kotov, Stefan, Dimitrova, Nadezhda, Walker, John D

“…Traditional attempts to model genotoxicity data have been limited to congeneric data sets, primarily because the mechanism of action was ignored, and…”
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Crystal structure and spectroscopic elucidation of 3-phenylpyridinium hydrogensquarate by Koleva, Bojidarka B., Kolev, Tsonko, Tsanev, Tsanko, Kotov, Stefan, Mayer-Figge, Heike, Spiteller, Michael, Sheldrick, William S.

“…The novel 3-phenylpyridinium hydrogensquarate (1) has been synthesized and its structure and properties are elucidated spectroscopically, thermally and…”
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Preparation and use of novel molybdenum-containing organic complexes as catalysts in the epoxidation of cyclohexene by Kotov, Stefan V, Georgieva, Mariana G, Kolev, Tsonko M

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Crystal structure, optical and magnetic properties of the bis(perchlorate) of 3,4-diaminopyridine by Koleva, Bojidarka B., Kolev, Tsonko, Tsanev, Tsanko, Kotov, Stefan, Mayer-Figge, Heike, Seidel, Rüdiger W., Sheldrick, William S.

“…3,4-diaminopyridinium bis(perchlorate) has been synthesized and its crystal structure has been solved by single crystal X-ray diffraction. The optical and…”
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Preparation of perfluorocarbon polymers containing phosphonic acid groups by Kotov, Stefan V., Pedersen, Scot D., Qiu, Weiming, Qiu, Zai-Ming, Burton, Donald J.

“…Several co- and ter-fluoropolymers based on tetrafluoroethylene (TFE) and perfluorovinylethers, such as CF 2=CFO(CF 2) 2P(O) (OC 2H 5) 2, CF 2=CFO(CF 2)…”
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