An Extremely Rare Case of Synchronous Occurrence in the Larynx of Intravascular Lymphoma and In Situ Squamous Cell Carcinoma

We present the first case of laryngeal intravascular lymphoma coexisting with in situ squamous cell carcinoma. The patient, a 53 years old man, presented with hoarseness starting a year ago and underwent laryngoscopy, which revealed two nodular lesions on his right vocal cord. The histological and i...

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Bibliographic Details
Published in:	Leukemia & lymphoma Vol. 44; no. 6; pp. 1053 - 1057
Main Authors:	Hadjileontis, Constantine G., Kostopoulos, Ioannis S., Kaloutsi, Vassiliki D., Nikolaou, Angelos C., Kotoula, Vassiliki A., Papadimitriou, Constantine S.
Format:	Journal Article
Language:	English
Published:	United States Informa UK Ltd 01-01-2003 Taylor & Francis
Subjects:	Antigens, CD - analysis Antineoplastic Combined Chemotherapy Protocols - administration & dosage Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biopsy Carcinoma in Situ - complications Carcinoma in Situ - drug therapy Carcinoma in Situ - pathology Carcinoma, Squamous Cell - complications Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Cyclophosphamide - administration & dosage Epirubicin - administration & dosage Humans Immunohistochemistry Laryngeal Neoplasms - complications Laryngeal Neoplasms - drug therapy Laryngeal Neoplasms - pathology Larynx Lymphoma Lymphoma - complications Lymphoma - drug therapy Lymphoma - pathology Male Middle Aged Prednisone - administration & dosage Squamous Cell Carcinoma Time Factors Treatment Outcome Vascular Neoplasms - complications Vascular Neoplasms - drug therapy Vascular Neoplasms - pathology Vincristine - administration & dosage
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Summary:	We present the first case of laryngeal intravascular lymphoma coexisting with in situ squamous cell carcinoma. The patient, a 53 years old man, presented with hoarseness starting a year ago and underwent laryngoscopy, which revealed two nodular lesions on his right vocal cord. The histological and immunohistochemical examination of the biopsy specimens established the diagnosis of in situ squamous cell carcinoma coexisting with intravascular lymphoma of T-cell origin. Taking in consideration all the available references, the larynx has not until now been reported as a primary site of involvement of intravascular (angiotropic) lymphomas, nor as a secondary location in the systematic course of this disease. Furthermore no cases have been reported in the literature, concerning the synchronous affection of the larynx by this lymphoma and in situ laryngeal carcinoma, or other type of neoplasm.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1042-8194 1029-2403
DOI:	10.1080/1042819031000063426