Search Results - "Kotiadis, Vassilios"

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health by Kotiadis, Vassilios N., Duchen, Michael R., Osellame, Laura D.

“…The maintenance of cell metabolism and homeostasis is a fundamental characteristic of living organisms. In eukaryotes, mitochondria are the cornerstone of…”
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Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering by Maffioletti, Sara Martina, Sarcar, Shilpita, Henderson, Alexander B.H., Mannhardt, Ingra, Pinton, Luca, Moyle, Louise Anne, Steele-Stallard, Heather, Cappellari, Ornella, Wells, Kim E., Ferrari, Giulia, Mitchell, Jamie S., Tyzack, Giulia E., Kotiadis, Vassilios N., Khedr, Moustafa, Ragazzi, Martina, Wang, Weixin, Duchen, Michael R., Patani, Rickie, Zammit, Peter S., Wells, Dominic J., Eschenhagen, Thomas, Tedesco, Francesco Saverio

“…Generating human skeletal muscle models is instrumental for investigating muscle pathology and therapy. Here, we report the generation of three-dimensional…”
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NRF2 Orchestrates the Metabolic Shift during Induced Pluripotent Stem Cell Reprogramming by Hawkins, Kate E., Joy, Shona, Delhove, Juliette M.K.M., Kotiadis, Vassilios N., Fernandez, Emilio, Fitzpatrick, Lorna M., Whiteford, James R., King, Peter J., Bolanos, Juan P., Duchen, Michael R., Waddington, Simon N., McKay, Tristan R.

“…The potential of induced pluripotent stem cells (iPSCs) in disease modeling and regenerative medicine is vast, but current methodologies remain inefficient…”
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Redox stress shortens lifespan through suppression of respiratory complex I in flies with mitonuclear incompatibilities by Camus, M. Florencia, Rodriguez, Enrique, Kotiadis, Vassilios, Carter, Hugh, Lane, Nick

“…Incompatibilities between mitochondrial and nuclear genes can perturb respiration, biosynthesis, signaling and gene expression. Here we investigate whether…”
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Constitutive activation of the PI3K-Akt-mTORC1 pathway sustains the m.3243 A > G mtDNA mutation by Chung, Chih-Yao, Singh, Kritarth, Kotiadis, Vassilios N., Valdebenito, Gabriel E., Ahn, Jee Hwan, Topley, Emilie, Tan, Joycelyn, Andrews, William D., Bilanges, Benoit, Pitceathly, Robert D. S., Szabadkai, Gyorgy, Yuneva, Mariia, Duchen, Michael R.

“…Mutations of the mitochondrial genome (mtDNA) cause a range of profoundly debilitating clinical conditions for which treatment options are very limited. Most…”
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Inositol trisphosphate receptor-mediated Ca2+ signalling stimulates mitochondrial function and gene expression in core myopathy patients by Suman, Matteo, Sharpe, Jenny A, Bentham, Robert B, Kotiadis, Vassilios N, Menegollo, Michela, Pignataro, Viviana, Molgó, Jordi, Muntoni, Francesco, Duchen, Michael R, Pegoraro, Elena, Szabadkai, Gyorgy

“…Abstract Core myopathies are a group of childhood muscle disorders caused by mutations of the ryanodine receptor (RyR1), the Ca2+ release channel of the…”
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Protein CoAlation: a redox-regulated protein modification by coenzyme A in mammalian cells by Tsuchiya, Yugo, Peak-Chew, Sew Yeu, Newell, Clare, Miller-Aidoo, Sheritta, Mangal, Sriyash, Zhyvoloup, Alexander, Bakovic, Jovana, Malanchuk, Oksana, Pereira, Gonçalo C, Kotiadis, Vassilios, Szabadkai, Gyorgy, Duchen, Michael R, Campbell, Mark, Cuenca, Sergio Rodriguez, Vidal-Puig, Antonio, James, Andrew M, Murphy, Michael P, Filonenko, Valeriy, Skehel, Mark, Gout, Ivan

“…Coenzyme A (CoA) is an obligatory cofactor in all branches of life. CoA and its derivatives are involved in major metabolic pathways, allosteric interactions…”
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AMPK activation protects against diet-induced obesity through Ucp1-independent thermogenesis in subcutaneous white adipose tissue by Pollard, Alice E., Martins, Luís, Muckett, Phillip J., Khadayate, Sanjay, Bornot, Aurélie, Clausen, Maryam, Admyre, Therese, Bjursell, Mikael, Fiadeiro, Rebeca, Wilson, Laura, Whilding, Chad, Kotiadis, Vassilios N., Duchen, Michael R., Sutton, Daniel, Penfold, Lucy, Sardini, Alessandro, Bohlooly-Y, Mohammad, Smith, David M., Read, Jon A., Snowden, Michael A., Woods, Angela, Carling, David

“…Obesity results from a chronic imbalance between energy intake and energy output but remains difficult to prevent or treat in humans. Adenosine monophosphate…”
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A genetic modifier suggests that endurance exercise exacerbates Huntington's disease by Corrochano, Silvia, Blanco, Gonzalo, Williams, Debbie, Wettstein, Jessica, Simon, Michelle, Kumar, Saumya, Moir, Lee, Agnew, Thomas, Stewart, Michelle, Landman, Allison, Kotiadis, Vassilios N, Duchen, Michael R, Wackerhage, Henning, Rubinsztein, David C, Brown, Steve D M, Acevedo-Arozena, Abraham

“…Abstract Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological…”
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H2O2 stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4 by Di, Yujun, Holmes, Emily J, Butt, Amna, Dawson, Keren, Mironov, Aleksandr, Kotiadis, Vassilios N, Gourlay, Campbell W, Jones, Nic, Wilkinson, Caroline R M

“…In fission yeast, the stress‐activated MAP kinase, Sty1, is activated via phosphorylation upon exposure to stress and orchestrates an appropriate response. Its…”
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Knockdown of aquaporin-8 induces mitochondrial dysfunction in 3T3-L1 cells by Ikaga, Reina, Namekata, Iyuki, Kotiadis, Vassilios N, Ogawa, Haruko, Duchen, Michael R, Tanaka, Hikaru, Iida-Tanaka, Naoko

“…Aquaporin-8 (AQP8), a member of the aquaporin water channel family, is expressed in various tissue and cells, including liver, testis, and pancreas. AQP8…”
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Identification of new surfaces of cofilin that link mitochondrial function to the control of multi-drug resistance by Kotiadis, Vassilios N, Leadsham, Jane E, Bastow, Emma L, Gheeraert, Aline, Whybrew, Jennafer M, Bard, Martin, Lappalainen, Pekka, Gourlay, Campbell W

“…ADF/cofilin family proteins are essential regulators of actin cytoskeletal dynamics. Recent evidence also implicates cofilin in the regulation of mitochondrial…”
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H 2 O 2 stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4: Regulation of S. pombe Sty1 by Ptc4 by Di, Yujun, Holmes, Emily J, Butt, Amna, Dawson, Keren, Mironov, Aleksandr, Kotiadis, Vassilios N, Gourlay, Campbell W, Jones, Nic, Wilkinson, Caroline R M

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H sub(2)O sub(2) stress-specific regulation of S. pombe MAPK Sty1 by mitochondrial protein phosphatase Ptc4 by Di, Yujun, Holmes, Emily J, Butt, Amna, Dawson, Keren, Mironov, Aleksandr, Kotiadis, Vassilios N, Gourlay, Campbell W, Jones, Nic, Wilkinson, Caroline R M

“…In fission yeast, the stress-activated MAP kinase, Sty1, is activated via phosphorylation upon exposure to stress and orchestrates an appropriate response. Its…”
Get full text