Search Results - "Kothapalli, Yugandhar"

Synthesis of Fluorinated Nucleosides/Nucleotides and Their Antiviral Properties by Kothapalli, Yugandhar, Jones, Ransom A, Chu, Chung K, Singh, Uma S

“…The FDA has approved several drugs based on the fluorinated nucleoside pharmacophore, and numerous drugs are currently in clinical trials. Fluorine-containing…”
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Enantioselective Synthesis of β-l-5-(E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) Uracil) (l-BHDU) via Chiral Pure l-Dioxolane by Kothapalli, Yugandhar, Chu, Chung K, Singh, Uma S

“…β-l-5-((E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) uracil (l-BHDU, 17) is a potent and selective inhibitor of the varicella-zoster…”
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Enantioselective Synthesis of β‑l‑5-[(E)‑2-Bromovinyl)-1-((2S,4S)‑2-(hydroxymethyl)-1,3-(dioxolane-4-yl) Uracil)] (l‑BHDU) via Chiral Pure l‑Dioxolane by Kothapalli, Yugandhar, Chu, Chung K., Singh, Uma S.

“…β-l-5-((E)-2-Bromovinyl)-1-((2S,4S)-2-(hydroxymethyl)-1,3-(dioxolane-4-yl) uracil (l-BHDU, 17) is a potent and selective inhibitor of the varicella-zoster…”
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Enantiospecific total synthesis of (−)-crotanecine by Kothapalli, Yugandhar, Puthukanoori, Ravi Kumar, Ranga, Mahesh, Alapati, Srinivasa Rao

“…[Display omitted] •Abundantly available d-ribose is used as chiral starting material.•A Baylis-Hillman reaction has been used to generate new stereo-genic…”
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Prodrug Strategies for the Development of β‑l‑5-((E)‑2-Bromovinyl)-1-((2S,4S)‑2-(hydroxymethyl)-1,3-(dioxolane-4-yl))uracil (l‑BHDU) against Varicella Zoster Virus (VZV) by Singh, Uma S., Konreddy, Ananda K., Kothapalli, Yugandhar, Liu, Dongmei, Lloyd, Megan G., Annavarapu, Vidya, White, Catherine A., Bartlett, Michael. G., Moffat, Jennifer F., Chu, Chung K.

“…Varicella zoster virus (VZV) establishes lifelong infection after primary disease and can reactivate. Several drugs are approved to treat VZV diseases, but new…”
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Enantiospecific first total synthesis of 7a(S)-p-hydroxyphenopyrrozin by Kothapalli, Yugandhar, Puthukanoori, Ravi Kumar, Alapati, Srinivasa Rao

“…An enantiospecific first total synthesis of metabolite 7a(S)-p-hydroxyphenopyrrozin 2, isolated from the cultured fungi Chromocleista sp. has been achieved…”
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A Stereoselective Synthesis of 4′‐α‐Fluoro‐methyl Carbocyclic Nucleoside Analogs by Singh, Uma S., Jones, Ransom A., Kothapalli, Yugandhar, Mulamoottil, Varughese A., Wei, Pingrong, Chu, Chung K.

“…The 4′ position modifications in carbocyclic nucleosides have not been investigated much as potential antiviral agents. Due to the higher ring strain and…”
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