Search Results - "Kothapalli, Kumar S"

Sustainable production of housefly (Musca domestica) larvae as a protein-rich feed ingredient by utilizing cattle manure by Hussein, Mahmoud, Pillai, Viju V, Goddard, Joshua M, Park, Hui G, Kothapalli, Kumar S, Ross, Deborah A, Ketterings, Quirine M, Brenna, J Thomas, Milstein, Mark B, Marquis, Helene, Johnson, Patricia A, Nyrop, Jan P, Selvaraj, Vimal

“…The common housefly, Musca domestica, is a considerable component of nutrient recycling in the environment. Use of housefly larvae to biodegrade manure…”
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Structural Identification of Monounsaturated Branched Chain Fatty Acid Methyl Esters by Combination of Electron Ionization and Covalent Adduct Chemical Ionization Tandem Mass Spectrometry by Wang, Zhen, Wang, Dong Hao, Park, Hui Gyu, Tobias, Herbert J, Kothapalli, Kumar S. D, Brenna, J. Thomas

“…Monounsaturated normal fatty acids (n-MUFA) and saturated branched chain fatty acids (BCFA) are structurally characterized by separate tandem mass spectrometry…”
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The fatty acid desaturase 2 (FADS2) gene product catalyzes Δ4 desaturation to yield n-3 docosahexaenoic acid and n-6 docosapentaenoic acid in human cells by Park, Hui Gyu, Park, Woo Jung, Kothapalli, Kumar S D, Brenna, J Thomas

“…Docosahexaenoic acid (DHA) is a Δ4-desaturated C22 fatty acid and the limiting highly unsaturated fatty acid (HUFA) in neural tissue. The biosynthesis of…”
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Fatty acid desaturase insertion-deletion polymorphism rs66698963 predicts colorectal polyp prevention by the n–3 fatty acid eicosapentaenoic acid: a secondary analysis of the seAFOod polyp prevention trial by Sun, Ge, Li, Yan Ning, Davies, John R, Block, Robert C, Kothapalli, Kumar SD, Brenna, J Thomas, Hull, Mark A

“…A fatty acid desaturase (FADS) insertion-deletion (Indel) polymorphism (rs66698963) influences the expression of FADS1, which controls the synthesis of n–6…”
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FADS2 function loss at the cancer hotspot 11q13 locus diverts lipid signaling precursor synthesis to unusual eicosanoid fatty acids by Park, Woo Jung, Kothapalli, Kumar S D, Lawrence, Peter, Brenna, J Thomas

“…Genes coding for the fatty acid desaturases (FADS1, 2, 3) localized at the cancer genomic hotspot 11q13 locus are required for the biosynthesis of 20 carbon…”
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Identification of genes mediating branched chain fatty acid elongation by Wang, Zhen, Wang, Dong Hao, Park, Hui Gyu, Yan, Yuanyuan, Goykhman, Yuliya, Lawrence, Peter, Kothapalli, Kumar S. D., Brenna, J. Thomas

“…Saturated branched chain fatty acids (BCFA) terminating with either a prop‐2‐yl (iso) or sec‐butan‐2‐yl (anteiso) group are common bioactive food components…”
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Fads3 modulates docosahexaenoic acid in liver and brain by Zhang, Ji Yao, Qin, Xia, Liang, Allison, Kim, Ellen, Lawrence, Peter, Park, Woo Jung, Kothapalli, Kumar S.D., Brenna, J. Thomas

“…Fatty acid desaturase 3 (FADS3) is the third member of the FADS gene cluster. FADS1 and FADS2 code for enzymes required for highly unsaturated fatty acid…”
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Alternative splicing generates novel Fads3 transcript in mice by Zhang, Ji Yao, Qin, Xia, Park, Hui Gyu, Kim, Ellen, Liu, Guowen, Kothapalli, Kumar S. D., Brenna, J. Thomas

“…Fads3 is the third member of the fatty acid desaturase gene cluster; with at least eight evolutionarily conserved alternative transcripts (AT), having no…”
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Polyunsaturated fatty acid biosynthesis pathway and genetics. implications for interindividual variability in prothrombotic, inflammatory conditions such as COVID-19 by Kothapalli, Kumar S.D., Park, Hui Gyu, Brenna, J. Thomas

“…•Severe COVID-19 is mediated by both a cytokine storm and a thrombotic storm.•HUFA balance in part determines inflammatory and thrombotic potential.•Genetic…”
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Alternative transcripts of fatty acid desaturase (FADS) genes by Thomas Brenna, J, Kothapalli, Kumar S.D, Jung Park, Woo

“…Abstract Alternative splicing is a major mechanism for increasing the range of products encoded by the genome. We recently reported positive identification of…”
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Growth, clinical chemistry and immune function in domestic piglets fed varying ratios of arachidonic acid and DHA by TYBURCZY, Cynthia, KOTHAPALLI, Kumar S. D, WOO JUNG PARK, BLANK, Bryant S, LIU, Ying-Chun, NAUROTH, Julie M, PAUL ZIMMER, J, SALEM, Norman, THOMAS BRENNA, J

“…In the USA, infant formulas contain long-chain PUFA arachidonic acid (ARA) and DHA in a ratio of 2:1 and comprise roughly 0·66 g/100 g and 0·33 g/100 g total…”
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Evaluation of bioequivalency and toxicological effects of three sources of arachidonic acid (ARA) in domestic piglets by Tyburczy, Cynthia, Brenna, Margaret E., DeMari, Joseph A., Kothapalli, Kumar S.D., Blank, Bryant S., Valentine, Helen, McDonough, Sean P., Banavara, Dattatreya, Diersen-Schade, Deborah A., Brenna, J. Thomas

“…► Dietary arachidonic acid (ARA) is a component of infant formula. ► We examine two commercial food sources of ARA for safety and efficacy in piglets. ► Both…”
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Differential cerebral cortex transcriptomes of baboon neonates consuming moderate and high docosahexaenoic acid formulas by Kothapalli, Kumar S D, Anthony, Joshua C, Pan, Bruce S, Hsieh, Andrea T, Nathanielsz, Peter W, Brenna, J Thomas

“…Docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (ARA, 20:4n-6) are the major long chain polyunsaturated fatty acids (LCPUFA) of the central nervous…”
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Fatty acid desaturase 2 (FADS2) but not FADS1 desaturates branched chain and odd chain saturated fatty acids by Wang, Zhen, Park, Hui Gyu, Wang, Dong Hao, Kitano, Riki, Kothapalli, Kumar S.D., Brenna, J. Thomas

“…Branched chain fatty acids (BCFA) and linear chain/normal odd chain fatty acids (n-OCFA) are major fatty acids in human skin lipids, especially sebaceous gland…”
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New understandings of the pathway of long-chain polyunsaturated fatty acid biosynthesis by Brenna, J. Thomas, Kothapalli, Kumar S.D.

“…Molecular studies have clarified the roles of the fatty acid desaturase (FADSx) and elongation of very long chain fatty acid (ELOVLx) genes, as well as…”
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Alternative splicing generates a novel FADS2 alternative transcript in baboons by Park, Woo Jung, Reardon, Holly T, Tyburczy, Cynthia, Kothapalli, Kumar S. D, Brenna, J. Thomas

“…The mammalian fatty acid desaturase 2 (FADS2) gene codes for catalytic activity considered to be the rate limited step in long chain polyunsaturated fatty acid…”
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Novel fatty acid desaturase 3 ( FADS3) transcripts generated by alternative splicing by Park, Woo Jung, Kothapalli, Kumar S.D., Reardon, Holly T., Kim, Luke Y., Brenna, J. Thomas

“…Fatty acid desaturase 1 and 2 ( FADS1 and FADS2) code for the key desaturase enzymes involved in the biosynthesis of long chain polyunsaturated fatty acids in…”
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Heart arachidonic acid is uniquely sensitive to dietary arachidonic acid and docosahexaenoic acid content in domestic piglets by Tyburczy, Cynthia, Kothapalli, Kumar S.D, Park, Woo Jung, Blank, Bryant S, Bradford, Kathryn L, Zimmer, J. Paul, Butt, Christopher M, Salem, Norman, Brenna, J. Thomas

“…Abstract This study determined the sensitivity of heart and brain arachidonic acid (ARA) and docosahexaenoic acid (DHA) to the dietary ARA level in a…”
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The polypyrimidine tract binding protein regulates desaturase alternative splicing and PUFA composition by Reardon, Holly T., Park, Woo Jung, Zhang, Jimmy, Lawrence, Peter, Kothapalli, Kumar S.D., Brenna, J. Thomas

“…The Δ6 desaturase, encoded by FADS2, plays a crucial role in omega-3 and omega-6 fatty acid synthesis. These fatty acids are essential components of the…”
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FADS2 function at the major cancer hotspot 11q13 locus alters fatty acid metabolism in cancer by Kothapalli, Kumar S.D., Park, Hui Gyu, Kothapalli, Niharika S.L., Brenna, J. Thomas

“…Dysregulation of fatty acid metabolism and de novo lipogenesis is a key driver of several cancer types through highly unsaturated fatty acid (HUFA) signaling…”
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