Search Results - "Kothanahally, Sharath Kumar S."

ST09, A Novel Curcumin Derivative, Blocks Cell Migration by Inhibiting Matrix Metalloproteases in Breast Cancer Cells and Inhibits Tumor Progression in EAC Mouse Tumor Models by Nirgude, Snehal, Mahadeva, Raghunandan, Koroth, Jinsha, Kumar, Sujeet, Kumar, Kothanahally S Sharath, Gopalakrishnan, Vidya, S Karki, Subhas S, Choudhary, Bibha

“…Curcumin is known for its anticancer and migrastatic activity in various cancers, including breast cancer. Newer curcumin derivatives are being explored to…”
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A trisubstituted pyrazole derivative reduces DMBA-induced mammary tumor growth in rats by inhibiting estrogen receptor-α expression by Ananda, Hanumappa, Sharath Kumar, Kothanahally S., Sudhanva, Muddenahalli S., Rangappa, Shobith, Rangappa, Kanchugarakoppal S.

“…Aberrant expression of estrogen receptor alpha (ER-α) is observed in many pathological complications like breast cancer, endometrial cancer, and in…”
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Identification of β‐aminopyrrolidine containing peptides as β‐amyloid aggregation inhibitors for Alzheimer's disease by Preetham, Habbanakuppe D., Muddegowda, Umashankara, Sharath Kumar, Kothanahally S., Rangappa, Shobith, Rangappa, Kanchugarakoppal S.

“…Alzheimer's disease (AD) is caused by a series of events initiated by the production and aggregation of the amyloid β‐protein (Aβ). In the early stages of the…”
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Pyrazole-based analogs as potential antibacterial agents against methicillin-resistance staphylococcus aureus (MRSA) and its SAR elucidation by Verma, Rameshwari, Verma, Santosh Kumar, Rakesh, Kadalipura P., Girish, Yarabahally R., Ashrafizadeh, Milad, Sharath Kumar, Kothanahally S., Rangappa, Kanchugarakoppal S.

“…Methicillin-resistant Staphylococcus aureus (MRSA) is becoming lethal to humanity due to easy transmission and difficult-to-treat skin and flimsy diseases. The…”
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Alternative Approach to Access 5‑Hydroxy-1H-pyrrol-2-(5H)-ones from Base-Induced Tandem Intramolecular Cyclization of Sulfur Ylide with Ketones and 1,3-Hydroxy Rearrangement by Preetham, Habbanakuppe D., Sharath Kumar, Kothanahally S., Kandaswamy, Aravind, Rangappa, Shobith, Gatasheh, Mansour K., Muddegowda, Umashankara, Rangappa, Kanchugarakoppal S.

“…An easily adaptable protocol for the preparation of 5-hydroxy-1H-pyrrol-2­(5H)-ones from readily available starting materials has been reported. The reaction…”
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Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: Approaching to a new era of cancer chemotherapy by Mirzaei, Sepideh, Gholami, Mohammad Hossein, Hashemi, Farid, Zabolian, Amirhossein, Hushmandi, Kiavash, Rahmanian, Vahid, Entezari, Maliheh, Girish, Yarabahally R., Sharath Kumar, Kothanahally S., Aref, Amir Reza, Makvandi, Pooyan, Ashrafizadeh, Milad, Zarrabi, Ali, Khan, Haroon

“…Although chemotherapy is a first option in treatment of cancer patients, drug resistance has led to its failure, requiring strategies to overcome it. Cancer…”
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Synthetic Utility of Propylphosphonic Anhydride–DMSO Media: An Efficient One-pot Three-component Synthesis of 2-Arylquinolines by Narasimhamurthy, Kereyagalahally H, Chandrappa, Siddappa, Kumar, Kothanahally S Sharath, Swaroop, Toreshettahally R, Rangappa, Kanchugarakoppal S

“…Propylphosphonic anhydride (T3P®)–DMSO-mediated one-pot three-component synthesis which provides 2-arylquinolines in a single step from benzyl alcohols,…”
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Fluorinated azoles as effective weapons in fight against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies by Zhao, Xuanming, Verma, Rameshwari, Sridhara, M.B., Sharath Kumar, Kothanahally S.

“…[Display omitted] •Fluorinated azoles displayed potent antibacterial activity against tested MRSA strains.•Structure-activity relationship is explained in…”
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Benzimidazole analogues as efficient arsenals in war against methicillin-resistance staphylococcus aureus (MRSA) and its SAR studies by Zha, Gao-Feng, Preetham, Habbanakuppe D., Rangappa, Shobith, Sharath Kumar, Kothanahally S., Girish, Yarabahally R., Rakesh, Kadalipura P., Ashrafizadeh, Milad, Zarrabi, Ali, Rangappa, Kanchugarakoppal S.

“…[Display omitted] •Benzimidazole and bis-benzimidazole derivatives displayed potent antibacterial activity against tested MRSA strains.•Structure-activity…”
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Novel oxolane derivative DMTD mitigates high glucose-induced erythrocyte apoptosis by regulating oxidative stress by Jagadish, Swamy, Hemshekhar, Mahadevappa, NaveenKumar, Somanathapura K., Sharath Kumar, Kothanahally S., Sundaram, Mahalingam S., Basappa, Girish, Kesturu S., Rangappa, Kanchugarakoppal S.

“…Chronic hyperglycemia is one of the characteristic conditions associated with Diabetes Mellitus (DM), which often exerts deleterious effects on erythrocyte…”
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Sulfur (SⅥ)-containing heterocyclic hybrids as antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA) and its SAR by Verma, Santosh Kumar, Rangappa, Shobith, Verma, Rameshwari, Xue, Fan, Verma, Shekhar, Sharath Kumar, Kothanahally S., Rangappa, Kanchugarakoppal S.

“…[Display omitted] •Sulfur (SⅥ)-containing heterocyclic hybrids displayed potent antibacterial activity against tested MRSA strains.•Structure-activity…”
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Autocyclized and oxidized forms of SCR7 induce cancer cell death by inhibiting nonhomologous DNA end joining in a Ligase IV dependent manner by Vartak, Supriya V., Swarup, Hassan A., Gopalakrishnan, Vidya, Gopinatha, Vindya K., Ropars, Virginie, Nambiar, Mridula, John, Franklin, Kothanahally, Sharath Kumar S., Kumari, Rupa, Kumari, Nitu, Ray, Ujjayinee, Radha, Gudapureddy, Dinesh, Depina, Pandey, Monica, Ananda, Hanumappa, Karki, Subhas S., Srivastava, Mrinal, Charbonnier, Jean Baptiste, Choudhary, Bibha, Mantelingu, Kempegowda, Raghavan, Sathees C.

“…Nonhomologous DNA end joining (NHEJ) is the major DNA double‐strand break (DSB) repair pathway in mammals. Previously, we have described a small molecule…”
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Antiproliferative and tumor inhibitory studies of 2,3 disubstituted 4-thiazolidinone derivatives by Sharath Kumar, Kothanahally S., Hanumappa, Ananda, Vetrivel, Maruthai, Hegde, Mahesh, Girish, Yarabhally R., Byregowda, Thinnali R., Rao, Suguna, Raghavan, Sathees C., Rangappa, Kanchugarakoppal S.

“…[Display omitted] 4-Thiazolidinone derivatives were synthesized using T3P®-DMSO media as a cyclodehydrating agent. All the molecules were tested for their…”
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Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents by Ananda, Hanumappa, Sharath Kumar, Kothanahally S., Nishana, Mayilaadumveettil, Hegde, Mahesh, Srivastava, Mrinal, Byregowda, Raghava, Choudhary, Bibha, Raghavan, Sathees C., Rangappa, Kanchugarakoppal S.

“…Pyrazole moiety represents an important category of heterocyclic compound in pharmaceutical and medicinal chemistry. The novel 1-aryl-3, 5-bis (het) aryl…”
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Synthesis and antiproliferative effect of novel 4-thiazolidinone-, pyridine- and piperazine-based conjugates on human leukemic cells by Sharath Kumar, Kothanahally S., Hanumappa, Ananda, Hegde, Mahesh, Narasimhamurthy, Kereyagalahally H., Raghavan, Sathees C., Rangappa, Kanchugarakoppal S.

“…The present work reveals the synthesis and antiproliferative effect of a series of 2, 3 disubstituted 4-thiazolidinone analogues on human leukemic cells. The…”
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Catalyst free sequential one‐pot reaction for the synthesis of 3‐indole propanoates/propanoic acid/propanamides as antituberculosis agents by Rajeev, Narasimhamurthy, Sharath Kumar, Kothanahally S., Bommegowda, Yadaganahalli K., Rangappa, Kanchugarakoppal S., Sadashiva, Marilinganadoddi P.

“…A highly efficient catalyst free one pot four component synthesis of highly functionalized three‐substituted indole derivatives has been reported. Thus,…”
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Platelet protective efficacy of 3,4,5 trisubstituted isoxazole analogue by inhibiting ROS-mediated apoptosis and platelet aggregation by Jagadish, Swamy, Rajeev, Narasimhamurthy, NaveenKumar, Somanathapura K., Sharath Kumar, Kothanahally S., Paul, Manoj, Hegde, Mahesh, Basappa, Sadashiva, Marilinganadoddi P., Girish, Kesturu S., Rangappa, Kanchugarakoppal S.

“…Thrombocytopenia is a major hematological concern in oxidative stress-associated pathologies and chronic clinical disorders, where premature platelet…”
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T3P®-DMSO mediated one pot cascade protocol for the synthesis of 4-thiazolidinones from alcohols by Sharath Kumar, Kothanahally S., Swaroop, Toreshettahally R., Harsha, Kachigere B., Narasimhamurthy, Kereyagalahally H., Rangappa, Kanchugarakoppal S.

“…R1, R2=H/Alkyl/Aryl/Heteroaryl and R3=Aryl/Heteroaryl. Propylphosphonic anhydride (T3P®)-DMSO mediated oxidation of alcohols to carbonyl compounds and their…”
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A Catalyst-free Green Protocol for the Synthesis of Pyranopyrazoles Using Room Temperature Ionic Liquid Choline Chloride-urea by Swaroop, Toreshettahally R., Sharath Kumar, Kothanahally S., Palanivelu, Mariyappan, Chaitanya, Somu, Rangappa, Kanchugarakoppal S.

“…An efficient and rapid four component reaction of aldehydes, malanonitrile, β‐ketoesters and hydrazine hydrate (or phenyl hydrazine) in environmentally benign…”
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AIE-featured tetraphenylethylene nanoarchitectures in biomedical application: Bioimaging, drug delivery and disease treatment by Sharath Kumar, Kothanahally S., Girish, Yarabahally R., Ashrafizadeh, Milad, Mirzaei, Sepideh, Rakesh, Kadalipura P., Hossein Gholami, Mohammad, Zabolian, Amirhossein, Hushmandi, Kiavash, Orive, Gorka, Kadumudi, Firoz Babu, Dolatshahi-Pirouz, Alireza, Thakur, Vijay Kumar, Zarrabi, Ali, Makvandi, Pooyan, Rangappa, Kanchugarakoppal S.

“…[Display omitted] •Various luminogens with AIE property (AIEgens) have been broadly utilized in biomedical field.•Tetraphenylethylene derivatives have…”
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