An emerging method in evaluation of reduced fetal movements using cerebroplacental ratio: A prospective case–control study

Aim Nearly half of the patients with stillbirths experience reduced fetal movements (RFM) in the preceding week. The standardized evaluation will help reduce stillbirths. Placental dysfunction is the underlying pathophysiology for RFM and low cerebroplacental ratio (CPR). We attempted to determine t...

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Published in:	The journal of obstetrics and gynaecology research Vol. 47; no. 12; pp. 4203 - 4209
Main Authors:	Inukollu, Pranadeep Reddy, Sulthana, Samiya, Solipuram, Divya, Kunamneni, Srividya, Kothagadi, Aravind Reddy
Format:	Journal Article
Language:	English
Published:	Kyoto, Japan John Wiley & Sons Australia, Ltd 01-12-2021 Wiley Subscription Services, Inc
Subjects:	Birth weight Case-Control Studies case–control study CPR Female Fetal monitoring Fetal Movement Fetuses Gestational Age Humans Maternal & child health MCA Doppler Patients Placenta - diagnostic imaging Pregnancy Pulsatile Flow reduced fetal movements Ultrasonic imaging Ultrasonography, Prenatal umbilical artery Doppler MCA Doppler reduced fetal movements CPR case-control study umbilical artery Doppler
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Summary:	Aim Nearly half of the patients with stillbirths experience reduced fetal movements (RFM) in the preceding week. The standardized evaluation will help reduce stillbirths. Placental dysfunction is the underlying pathophysiology for RFM and low cerebroplacental ratio (CPR). We attempted to determine the application of CPR in evaluation of RFM. Methods A prospective case–control study with 100 patients each of cases and controls were studied at a tertiary care hospital. Middle cerebral artery pulsatility index (MCA‐PI), umbilical artery PI (UA‐PI), and CPR were calculated as multiples of median (MoM) in patients presenting with RFM after 30 weeks and their matched controls and followed up. CPR values of various gestation ranges and single versus multiple episodes of RFM were analyzed. Results Compared to controls, women with RFM showed a significantly low MCA PI MoM (0.94 vs 1.4; p = 0.00008) and low CPR MoM (1.48 vs 1.6; p = 0.015). Women with multiple RFM episodes had lower CPR MoM (1.2 vs 1.5; p < 0.00001) compared to single episode RFM. Multiple RFM episode patients had low MCA PI MoM (1.3 vs 1.4; p = 0.0038) and low CPR MoM (1.2 vs 1.6; p < 0.00001) compared to controls. There was a significantly low CPR in 32–34 weeks (1.35 vs 1.81; p = 0.004) and 36–38 weeks subgroups (1.39 vs 1.58; p = 0.002). No significant difference in birthweight centiles or AGA versus SGA categories between cases and controls was noted questioning current guidelines where ultrasound evaluation is done for RFM patients with FGR. Conclusion Incorporation of routine CPR measurements can standardize evaluation of RFM patients, especially those with AGA to pick up patients at risk of poor outcome and bring down stillbirth rates.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1341-8076 1447-0756
DOI:	10.1111/jog.15021