Contribution of Protein Intake and Concurrent Exercise to Skeletal Muscle Quality with Aging

Contribution of Protein Intake and Concurrent Exercise to Skeletal Muscle Quality with Aging

The use of magnetic resonance imaging (MRI) derived functional cross-sectional area (FCSA) and intramuscular adipose tissue (IMAT) to define skeletal muscle quality is of fundamental importance in order to understand aging and inactivity-related loss of muscle mass. This study examined factors assoc...

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Bibliographic Details
Published in:The Journal of frailty & aging Vol. 9; no. 1; pp. 51 - 56
Main Authors: Dicks, N D, Kotarsky, C J, Trautman, K A, Barry, A M, Keith, J F, Mitchell, S, Byun, W, Stastny, S N, Hackney, K J
Format: Journal Article
Language:English
Published: France Springer Nature B.V 01-01-2020
Subjects:
Accelerometers
Adult
Aerobic exercise
Age groups
Aged
Aging
Aging - physiology
Body fat
Cross-Sectional Studies
Diaries
Dietary Proteins - administration & dosage
Exercise
Exercise - physiology
Female
Fitness training programs
Food
Functional magnetic resonance imaging
Healthy food
Humans
Limbs
Lower limbs
Magnetic resonance imaging
Male
Metabolism
Middle age
Middle Aged
Muscle, Skeletal - physiology
Musculoskeletal system
Physical activity
Physical fitness
Proteins
Sedentary
Variance analysis
Young Adult
United States > US
North Dakota
functional CSA
aging
IMAT
Protein
physical activity
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Summary:The use of magnetic resonance imaging (MRI) derived functional cross-sectional area (FCSA) and intramuscular adipose tissue (IMAT) to define skeletal muscle quality is of fundamental importance in order to understand aging and inactivity-related loss of muscle mass. This study examined factors associated with lower-extremity skeletal muscle quality in healthy, younger, and middle-aged adults. Cross-sectional study. Ninety-eight participants (53% female) were classified as younger (20-35 years, n=50) or middle-aged (50-65 years, n=48) as well as sedentary (≤1 day per week) or active (≥3 days per week) on self-reported concurrent exercise (aerobic and resistance). All participants wore an accelerometer for seven days, recorded a three-day food diary, and participated in magnetic resonance imaging (MRI) of the lower limbs. Muscle cross-sectional area (CSA) was determined by tracing the knee extensors (KE) and plantar flexors, while muscle quality was established through the determination of FCSA and IMAT via color thresholding. One-way analysis of variance and stepwise regression models were performed to predict FCSA and IMAT. KE-IMAT (cm2) was significantly higher among sedentary (3.74 ± 1.93) vs. active (1.85 ± 0.56) and middle-aged (3.14 ± 2.05) vs. younger (2.74 ± 1.25) (p < 0.05). Protein intake (g•kg•day-1) was significantly higher in active (1.63 ± 0.55) vs. sedentary (1.19 ± 0.40) (p < 0.05). Sex, age, concurrent exercise training status, and protein intake were significant predictors of KE FCSA (R2 = 0.71, p < 0.01), while concurrent exercise training status and light physical activity predicted 33% of the variance in KE IMAT (p < 0.01). Concurrent exercise training, dietary protein intake, and light physical activity are significant determinants of skeletal muscle health and require further investigation to mitigate aging and inactivity-related loss of muscle quality.
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ISSN:2260-1341
2273-4309
DOI:10.14283/jfa.2019.40