Difference between Keratinized- and Non-Keratinized-Originating Epithelium in the Process of Immune Escape of Oral Squamous Cell Carcinoma

Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand 1 (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases, including oral cancer. Cancer cells usually escape from the immune system and acquire proliferative capacity and inva...

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Published in:	International journal of molecular sciences Vol. 25; no. 7; p. 3821
Main Authors:	Kitsukawa, Yoshiaki, Fukumoto, Chonji, Hyodo, Toshiki, Komiyama, Yuske, Shiraishi, Ryo, Koike, Aya, Yagisawa, Shuma, Kunitomi, Yosuke, Hasegawa, Tomonori, Kotani, Wataru, Ishida, Kazuyuki, Wakui, Takahiro, Kawamata, Hitoshi
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-04-2024
Subjects:	Antibodies Apoptosis B cells B7-H1 Antigen Carcinoma, Squamous Cell CD47 Antigen Epithelium Head & neck cancer Head and Neck Neoplasms Humans immune checkpoint immune escape Immune response Immune system Ligands Medical colleges Medical prognosis Metastasis Mouth Neoplasms Oral cancer oral squamous cell carcinoma Programmed Cell Death 1 Receptor programmed cell death 1-ligand 1 (PD-L1) programmed death receptor-1 (PD-1) Radiation therapy Retrospective Studies Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Surgery Tongue tumor immunity Tumor Microenvironment Tumors Viral antibodies Japan programmed death receptor-1 (PD-1) programmed cell death 1-ligand 1 (PD-L1) immune checkpoint immune escape oral squamous cell carcinoma tumor immunity CD47
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Summary:	Immune checkpoint inhibitors (ICIs), including anti-programmed cell death 1 ligand 1 (PD-L1) antibodies, are significantly changing treatment strategies for human malignant diseases, including oral cancer. Cancer cells usually escape from the immune system and acquire proliferative capacity and invasive/metastatic potential. We have focused on the two immune checkpoints, PD-1/PD-L1 and CD47/SIRPα, in the tumor microenvironment of oral squamous cell carcinoma (OSCC), performed a retrospective analysis of the expression of seven immune-related factors (PD-L1, PD-1, CD4, CD8, CD47, CD56 and CD11c), and examined their correlation with clinicopathological status. As a result, there were no significant findings relating to seven immune-related factors and several clinicopathological statuses. However, the immune checkpoint-related factors (PD-1, PD-L1, CD47) were highly expressed in non-keratinized epithelium-originated tumors when compared to those in keratinized epithelium-originated tumors. It is of interest that immunoediting via immune checkpoint-related factors was facilitated in non-keratinized sites. Several researchers reported that the keratinization of oral mucosal epithelia affected the immune response, but our present finding is the first study to show a difference in tumor immunity in the originating epithelium of OSCC, keratinized or non-keratinized. Tumor immunity, an immune escape status of OSCC, might be different in the originating epithelium, keratinized or non-keratinized.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms25073821