Search Results - "Kotake, A N"

Dose escalation safety and tolerance study of the competitive NMDA antagonist selfotel (CGS 19755) in neurosurgery patients by Yenari, M A, Bell, T E, Kotake, A N, Powell, M, Steinberg, G K

“…Selfotel (CGS 19755), a competitive N-methyl-D-aspartate antagonist, is neuroprotective in experimental models of ischemic cerebral injury. We studied the…”
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Variations in demethylation of N-methylnaltrexone in mice, rats, dogs, and humans by Kotake, A N, Kuwahara, S K, Burton, E, McCoy, C E, Goldberg, L I

“…1. Rats and mice have a greater capacity than dogs or humans to N-demethylate the quaternary ammonium compound, N-methylnaltrexone. 2. In dogs, following the…”
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High-Performance Liquid Chromatography Technique for Resolving Multiple Forms of Hepatic Membrane-Bound Cytochrome P-450 by Kotake, Alvin N., Funae, Yoshihiko

“…Solubilized hepatic microsomal cytochrome P-450 from rats was resolved into 12 different heme-containing components by ion-exchange high-performance liquid…”
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Aminopyrine infusion breath test for the determination of changes in P450 metabolism in vivo by Kuwahara, S K, Shinn, T J, Schreider, B D, Phan, M L, Kotake, A N

“…1. An osmotic mini-pump was used to maintain a constant infusion of radiolabelled [N-dimethyl-14C] aminopyrine into a rat. After implanting the mini-pump,…”
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The Caffeine Breath Test and Caffeine Urinary Metabolite Ratios in the Michigan Cohort Exposed to Polybrominated Biphenyls: A Preliminary Study by Lambert, George H., Schoeller, Dale A., Harold E. B. Humphrey, Kotake, Alvin N., Lietz, Helen, Campbell, Monica, Kalow, Werner, Spielberg, Stephen P., Budd, Marvin

“…A field biochemical epidemiology study was conducted using the Michigan cohort consisting of 51 rural residents exposed to polybrominated biphenyls (PBB). The…”
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The aminopyrine breath test does not correlate with histologic disease severity in patients with cholestasis by Baker, A L, Krager, P S, Kotake, A N, Schoeller, D A

“…To determine whether the aminopyrine breath test can be used to document the presence of cirrhosis in patients with cholestatic liver disease, 19 patients (13…”
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The in vivo evaluation of the effect of age and sex on the developmental profile of aminopyrine N-demethylase activity in the newborn rat by Kotake, A N, Starr, R M

“…Standard methods for studying the maturation of the hepatic monooxygenase system in neonatal rats require killing groups of animals at various ages. We have…”
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Differential haemin-mediated restoration of cytochrome P-450 N-demethylases after inactivation by allylisopropylacetamide by Bornheim, L M, Kotake, A N, Correia, M A

“…Administration of allylisopropylacetamide (AIA) to phenobarbital-pretreated rats results in the destruction of several phenobarbital-inducible cytochrome P-450…”
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Effects of dietary protein on theophylline pharmacokinetics and caffeine and aminopyrine breath tests by Juan, D, Worwag, E M, Schoeller, D A, Kotake, A N, Hughes, R L, Frederiksen, M C

“…The effects of low- and high-protein diets on theophylline kinetics and the time course of changes in 13C-labeled caffeine and aminopyrine CO2 breath tests…”
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Clinical utility of breath tests for the assessment of hepatic function by Baker, A L, Kotake, A N, Schoeller, D A

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Effects of pregnancy on the cytochrome P-450 system in mice by Lambert, G H, Lietz, H W, Kotake, A N

“…The effects of pregnancy on the hepatic cytochrome P-450-dependent mixed-function monooxygenase system (P-450) from day 6 to day 18 of gestation were examined…”
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Microsomal spectral properties and narcotic N-demethylase activity in methadone-dependent rats by Spaulding, T C, Kotake, A N, Takemori, A E

“…Rats were given access ad lib. to various concentrations (0.3 to 1.0 mg/ml) of methadone hydrochloride dissolved in sucrose solution. The N-demethylation of…”
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New high-performance liquid chromatographic assay for plasma doxorubicin by Kotake, A N, Vogelzang, N J, Larson, R A, Choporis, N

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The effect of age, gender, and sexual maturation on the caffeine breath test by Lambert, G H, Schoeller, D A, Kotake, A N, Flores, C, Hay, D

“…This study demonstrated the feasibility of utilizing the (3-13C-methyl) caffeine breath test (CBT) in children and adolescents, and examined the effect of…”
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The effect of diazepam on the metabolism of methadone by the liver of methadone-dependent rats by Spaulding, T C, Minium, L, Kotake, A N, Takemori, A E

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Characteristics of the vascular dopamine receptor: comparison with other receptors by Goldberg, L I, Kohli, J D, Kotake, A N, Volkman, P H

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Determination of the 5-lipoxygenase inhibitor (CGS 8515) in plasma by high-performance liquid chromatography using reductive electrochemical detection by Kuwahara, S K, Brubaker, W F, Williams, E, Tripp, S, Douglas, F L, Kotake, A N

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Pharmacokinetic screening of o-naphthoquinone 5-lipoxygenase inhibitors by ASHOK RAKHIT, KUWAHARA, S. K, JONES, D. R, SOLIMAN, V. F, KOTAKE, A. N, OGLESBY, T. D, WASLEY, J. W. F, TRIPP, S. L, DOUGLAS, F. L

“…The o-naphthoquinone derivative, CGS 8515 (I), is a potent inhibitor (IC50, 0.1 microM) of 5-lipoxygenase, but its therapeutic potential is compromised by a…”
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The CO2 breath tests as monitors of the cytochrome P450 dependent mixed function monooxygenase system by Lambert, G H, Kotake, A N, Schoeller, D

“…The CBT and ABT are simple to conduct and are sensitive, reproducible monitors of hepatic enzyme function. They monitor functional hepatic mass at the time the…”
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The caffeine CO2 breath test: dose response and route of N-demethylation in smokers and nonsmokers by Kotake, A N, Schoeller, D A, Lambert, G H, Baker, A L, Schaffer, D D, Josephs, H

“…The optimal conditions for performing the caffeine CO2 breath test (CBT) were investigated in smokers and nonsmokers. Caffeine labeled with 13C or 14C in all…”
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