Search Results - "Kotaja, Noora"

MicroRNAs and spermatogenesis by Kotaja, Noora, Ph.D

“…In mammals, male gametes are produced inside the testis by spermatogenesis, which has three phases: mitotic proliferation of spermatogonia, meiosis of…”
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Transcriptome profiling of the murine testis during the first wave of spermatogenesis by Laiho, Asta, Kotaja, Noora, Gyenesei, Attila, Sironen, Anu

“…Correct gene expression patterns form the basis for male germ cell differentiation and male fertility. Although previous studies have elucidated the importance…”
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SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation by Lehti, Mari S, Zhang, Fu-Ping, Kotaja, Noora, Sironen, Anu

“…Sperm differentiation requires specific protein transport for correct sperm tail formation and head shaping. A transient microtubular structure, the manchette,…”
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piRNA-directed cleavage of meiotic transcripts regulates spermatogenesis by Goh, Wee Siong Sho, Falciatori, Ilaria, Tam, Oliver H, Burgess, Ralph, Meikar, Oliver, Kotaja, Noora, Hammell, Molly, Hannon, Gregory J

“…MIWI catalytic activity is required for spermatogenesis, indicating that piRNA-guided cleavage is critical for germ cell development. To identify meiotic piRNA…”
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Chromatoid body and small RNAs in male germ cells by Meikar, Oliver, Da Ros, Matteo, Korhonen, Hanna, Kotaja, Noora

“…The chromatoid body (CB) is a germ granule in the cytoplasm of postmeiotic haploid round spermatids that is loaded with RNA and RNA-binding proteins. Following…”
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Lack of androgen receptor SUMOylation results in male infertility due to epididymal dysfunction by Zhang, Fu-Ping, Malinen, Marjo, Mehmood, Arfa, Lehtiniemi, Tiina, Jääskeläinen, Tiina, Niskanen, Einari A., Korhonen, Hanna, Laiho, Asta, Elo, Laura L., Ohlsson, Claes, Kotaja, Noora, Poutanen, Matti, Sipilä, Petra, Palvimo, Jorma J.

“…Androgen receptor (AR) is regulated by SUMOylation at its transactivation domain. In vitro, the SUMOylation is linked to transcriptional repression and/or…”
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Single-Cell Proteomics Reveals the Defined Heterogeneity of Resident Macrophages in White Adipose Tissue by Félix, Inês, Jokela, Heli, Karhula, Joonas, Kotaja, Noora, Savontaus, Eriika, Salmi, Marko, Rantakari, Pia

“…Adipose tissue macrophages (ATMs) regulate homeostasis and contribute to the metabolically harmful chronic inflammation in obese individuals. While evident…”
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Chromatin remodelers HELLS, WDHD1 and BAZ1A are dynamically expressed during mouse spermatogenesis by Prakash Yadav, Ram, Leskinen, Sini, Ma, Lin, Mäkelä, Juho-Antti, Kotaja, Noora

“…In brief Proper regulation of heterochromatin is critical for spermatogenesis. This study reveals the dynamic localization patterns of distinct chromatin…”
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Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility by Zimmermann, Céline, Romero, Yannick, Warnefors, Maria, Bilican, Adem, Borel, Christelle, Smith, Lee B, Kotaja, Noora, Kaessmann, Henrik, Nef, Serge

“…Small non-coding RNAs act as critical regulators of gene expression and are essential for male germ cell development and spermatogenesis. Previously, we showed…”
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An atlas of chromatoid body components by Meikar, Oliver, Vagin, Vasily V, Chalmel, Frédéric, Sõstar, Karin, Lardenois, Aurélie, Hammell, Molly, Jin, Ying, Da Ros, Matteo, Wasik, Kaja A, Toppari, Jorma, Hannon, Gregory J, Kotaja, Noora

“…The genome of male germ cells is actively transcribed during spermatogenesis to produce phase-specific protein-coding mRNAs and a considerable amount of…”
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Dicer is required for haploid male germ cell differentiation in mice by Korhonen, Hanna M, Meikar, Oliver, Yadav, Ram Prakash, Papaioannou, Marilena D, Romero, Yannick, Da Ros, Matteo, Herrera, Pedro L, Toppari, Jorma, Nef, Serge, Kotaja, Noora

“…The RNase III endonuclease Dicer is an important regulator of gene expression that processes microRNAs (miRNAs) and small interfering RNAs (siRNAs). The…”
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miR-18, a member of Oncomir-1, targets heat shock transcription factor 2 in spermatogenesis by Björk, Johanna K, Sandqvist, Anton, Elsing, Alexandra N, Kotaja, Noora, Sistonen, Lea

“…miR-18 belongs to the Oncomir-1 or miR-17~92 cluster that is intimately associated with the occurrence and progression of different types of cancer. However,…”
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Exonuclease Domain-Containing 1 Enhances MIWI2 piRNA Biogenesis via Its Interaction with TDRD12 by Pandey, Radha Raman, Homolka, David, Olotu, Opeyemi, Sachidanandam, Ravi, Kotaja, Noora, Pillai, Ramesh S.

“…PIWI proteins and their associated small RNAs, called PIWI-interacting RNAs (piRNAs), restrict transposon activity in animal gonads to ensure fertility…”
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SPEF2 functions in microtubule-mediated transport in elongating spermatids to ensure proper male germ cell differentiation by Lehti, Mari S., Zhang, Fu-Ping, Kotaja, Noora, Sironen, Anu

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The Chromatoid Body of Male Germ Cells: Similarity with Processing Bodies and Presence of Dicer and MicroRNA Pathway Components by Kotaja, Noora, Bhattacharyya, Suvendra N., Jaskiewicz, Lukasz, Kimmins, Sarah, Parvinen, Martti, Filipowicz, Witold, Sassone-Corsi, Paolo

“…The chromatoid body is a perinuclear, cytoplasmic cloud-like structure in male germ cells whose function has remained elusive. Here we show that the chromatoid…”
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Dicer1 depletion in male germ cells leads to infertility due to cumulative meiotic and spermiogenic defects by Romero, Yannick, Meikar, Oliver, Papaioannou, Marilena D, Conne, Béatrice, Grey, Corinne, Weier, Manuela, Pralong, François, De Massy, Bernard, Kaessmann, Henrik, Vassalli, Jean-Dominique, Kotaja, Noora, Nef, Serge

“…Spermatogenesis is a complex biological process that requires a highly specialized control of gene expression. In the past decade, small non-coding RNAs have…”
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Interplay of PIWI/Argonaute protein MIWI and kinesin KIF17b in chromatoid bodies of male germ cells by Kotaja, Noora, Lin, Haifan, Parvinen, Martti, Sassone-Corsi, Paolo

“…Chromatoid bodies are thought to act as male-germ-cell-specific platforms for the storing and processing of haploid transcripts. The molecular mechanisms…”
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Expression of SPEF2 During Mouse Spermatogenesis and Identification of IFT20 as an Interacting Protein by SIRONEN, Anu, HANSEN, Jeanette, THOMSEN, Bo, ANDERSSON, Magnus, VILKKI, Johanna, TOPPARI, Jorma, KOTAJA, Noora

“…SPEF2 is expressed in all ciliated cells and is essential for correct sperm tail development and male fertility. We have previously identified a mutation…”
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PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases by Kotaja, Noora, Karvonen, Ulla, Jänne, Olli A., Palvimo, Jorma J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Polar Nuclear Localization of H1T2, a Histone H1 Variant, Required for Spermatid Elongation and DNA Condensation during Spermiogenesis by Martianov, Igor, Brancorsini, Stefano, Catena, Raffaella, Gansmuller, Anne, Kotaja, Noora, Parvinen, Martti, Sassone-Corsi, Paolo, Davidson, Irwin, Yanagimachi, Ryuzo

“…Spermiogenesis entails a major biochemical and morphological restructuring of the germ cell involving replacement of the somatic histones by protamines packing…”
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