Search Results - "Kosuke Kaji"

Can portal hypertension and hepatic decompensation be predicted? by Kaji, Kosuke, Yoshiji, Hitoshi

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Sodium glucose cotransporter 2 inhibitor canagliflozin attenuates liver cancer cell growth and angiogenic activity by inhibiting glucose uptake by Kaji, Kosuke, Nishimura, Norihisa, Seki, Kenichiro, Sato, Shinya, Saikawa, Soichiro, Nakanishi, Keisuke, Furukawa, Masanori, Kawaratani, Hideto, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Yoshiji, Hitoshi

“…Sodium‐glucose cotransporter 2 inhibitors (SGLT2‐Is) comprise a new class of antidiabetic agents that inhibit glucose reabsorption in the renal proximal…”
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Rifaximin ameliorates hepatic encephalopathy and endotoxemia without affecting the gut microbiome diversity by Kaji, Kosuke, Takaya, Hiroaki, Saikawa, Soichiro, Furukawa, Masanori, Sato, Shinya, Kawaratani, Hideto, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Mitoro, Akira, Yoshiji, Hitoshi

“…AIM To determine the efficacy of rifaximin for hepatic encephalopathy(HE) with the linkage of gut microbiome in decompensated cirrhotic patients.METHODS Twenty…”
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Relationship between hepatic progenitor cell-mediated liver regeneration and non-parenchymal cells by Kitade, Mitsuteru, Kaji, Kosuke, Yoshiji, Hitoshi

“…Hepatic progenitor cells (HPCs) are thought to reside in the canals of Hering and can be activated and contribute to liver regeneration in response to liver…”
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Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis by Enomoto, Masahide, Kaji, Kosuke, Nishimura, Norihisa, Fujimoto, Yuki, Murata, Koji, Takeda, Soichi, Tsuji, Yuki, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

“…Although gut-derived lipopolysaccharide (LPS) affects the progression of non-alcoholic steatohepatitis (NASH) pathogenesis, few studies have focused on this…”
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Efficacy of a dedicated plastic stent in endoscopic ultrasound-guided hepaticogastrostomy during the learning curve: cumulative multi-center experience by Kitagawa, Koh, Mitoro, Akira, Minami, Ryuki, Nagamatsu, Shinsaku, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Nishimura, Norihisa, Sawada, Yasuhiko, Namisaki, Tadashi, Akahane, Takemi, Kaji, Kosuke, Tomooka, Fumimasa, Asada, Shohei, Kaneko, Miki, Yoshiji, Hitoshi

“…Currently, there are no reports on the learning curve of endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) using dedicated plastic stents. Therefore,…”
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Gut dysbiosis associated with clinical prognosis of patients with primary biliary cholangitis by Furukawa, Masanori, Moriya, Kei, Nakayama, Jiro, Inoue, Takako, Momoda, Rie, Kawaratani, Hideto, Namisaki, Tadashi, Sato, Shinya, Douhara, Akitoshi, Kaji, Kosuke, Kitade, Mitsuteru, Shimozato, Naotaka, Sawada, Yasuhiko, Saikawa, Soichiro, Takaya, Hiroaki, Kitagawa, Koh, Akahane, Takemi, Mitoro, Akira, Yamao, Junichi, Tanaka, Yasuhito, Yoshiji, Hitoshi

“…Aim Although some relationships between gut microbiota and liver diseases have been reported, it remains uncertain whether changes in gut microbiota owing to…”
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Intestinal Permeability Is a Mechanical Rheostat in the Pathogenesis of Liver Cirrhosis by Nishimura, Norihisa, Kaji, Kosuke, Kitagawa, Koh, Sawada, Yasuhiko, Furukawa, Masanori, Ozutsumi, Takahiro, Fujinaga, Yukihisa, Tsuji, Yuki, Takaya, Hiroaki, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Fukui, Hiroshi, Yoshiji, Hitoshi

“…Recent studies have suggested that an alteration in the gut microbiota and their products, particularly endotoxins derived from Gram-negative bacteria, may…”
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Atorvastatin Augments Gemcitabine-Mediated Anti-Cancer Effects by Inhibiting Yes-Associated Protein in Human Cholangiocarcinoma Cells by Kitagawa, Koh, Moriya, Kei, Kaji, Kosuke, Saikawa, Soichiro, Sato, Shinya, Nishimura, Norihisa, Namisaki, Tadashi, Akahane, Takemi, Mitoro, Akira, Yoshiji, Hitoshi

“…Cholangiocarcinoma (CCA) is associated with high mortality rates because of its resistance to conventional gemcitabine-based chemotherapy…”
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Dipeptidyl peptidase-4 inhibitor attenuates hepatic fibrosis via suppression of activated hepatic stellate cell in rats by Kaji, Kosuke, Yoshiji, Hitoshi, Ikenaka, Yasuhide, Noguchi, Ryuichi, Aihara, Yosuke, Douhara, Akitoshi, Moriya, Kei, Kawaratani, Hideto, Shirai, Yusaku, Yoshii, Junichi, Yanase, Koji, Kitade, Mitsuteru, Namisaki, Tadashi, Fukui, Hiroshi

“…Background Dipeptidyl peptidase-4 inhibitor (DPP4-I) is clinically used as a new oral antidiabetic agent. Although DPP4 is reportedly associated with the…”
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Angiotensin receptor blockade attenuates cholangiocarcinoma cell growth by inhibiting the oncogenic activity of Yes-associated protein by Saikawa, Soichiro, Kaji, Kosuke, Nishimura, Norihisa, Seki, Kenichiro, Sato, Shinya, Nakanishi, Keisuke, Kitagawa, Koh, Kawaratani, Hideto, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Mitoro, Akira, Yoshiji, Hitoshi

“…Cholangiocarcinoma (CCA) is a destructive malignancy with limited responsiveness to conventional chemotherapy. Although angiotensin receptor blockers (ARBs)…”
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Role of Epiregulin on Lipopolysaccharide-Induced Hepatocarcinogenesis as a Mediator via EGFR Signaling in the Cancer Microenvironment by Kubo, Takahiro, Nishimura, Norihisa, Kaji, Kosuke, Tomooka, Fumimasa, Shibamoto, Akihiko, Iwai, Satoshi, Suzuki, Junya, Kawaratani, Hideto, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

“…Lipopolysaccharides (LPSs) have been reported to be important factors in promoting the progression of hepatocellular carcinoma (HCC), but the corresponding…”
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Combining probiotics and an angiotensin‐II type 1 receptor blocker has beneficial effects on hepatic fibrogenesis in a rat model of non‐alcoholic steatohepatitis by Sawada, Yasuhiko, Kawaratani, Hideto, Kubo, Takuya, Fujinaga, Yukihisa, Furukawa, Masanori, Saikawa, Soichiro, Sato, Shinya, Seki, Kenichiro, Takaya, Hiroaki, Okura, Yasushi, Kaji, Kosuke, Shimozato, Naotaka, Mashitani, Tsuyoshi, Kitade, Mitsuteru, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Mitoro, Akira, Yamao, Junichi, Yoshiji, Hitoshi

“…Aim Intestinal endotoxin is important for the progression of non‐alcoholic steatohepatitis (NASH). Circulating endotoxin levels are elevated in most animal…”
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DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration by Kaji, Kosuke, Factor, Valentina M., Andersen, Jesper B., Durkin, Marian E., Tomokuni, Akira, Marquardt, Jens U., Matter, Matthias S., Hoang, Tanya, Conner, Elizabeth A., Thorgeirsson, Snorri S.

“…DNA methyltransferase 1 (DNMT1) is an essential regulator maintaining both epigenetic reprogramming during DNA replication and genome stability. We…”
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Rifaximin enhances the L‑carnitine‑mediated preventive effects on skeletal muscle atrophy in cirrhotic rats by modulating the gut‑liver‑muscle axis by Murata, Koji, Kaji, Kosuke, Nishimura, Norihisa, Enomoto, Masahide, Fujimoto, Yuki, Takeda, Soichi, Tsuji, Yuki, Fujinaga, Yukihisa, Takaya, Hiroaki, Kawaratani, Hideto, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

“…The gut-liver-muscle axis is associated with the development of sarcopenia in liver cirrhosis. The present study aimed to illustrate the combined effects of…”
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Effective Combination Therapy of Angiotensin-II Receptor Blocker and Rifaximin for Hepatic Fibrosis in Rat Model of Nonalcoholic Steatohepatitis by Fujinaga, Yukihisa, Kawaratani, Hideto, Kaya, Daisuke, Tsuji, Yuki, Ozutsumi, Takahiro, Furukawa, Masanori, Kitagawa, Koh, Sato, Shinya, Nishimura, Norihisa, Sawada, Yasuhiko, Takaya, Hiroaki, Kaji, Kosuke, Shimozato, Naotaka, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Mitoro, Akira, Yoshiji, Hitoshi

“…The progression of nonalcoholic steatohepatitis (NASH) is complicated. The multiple parallel-hits theory is advocated, which includes adipocytokines, insulin…”
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Zinc Supplementation and an Improved Quality of Life in Patients with Autoimmune Hepatitis by Moriya, Kei, Saeki, Keigo, Nishimura, Norihisa, Sato, Shinya, Sawada, Yasuhiko, Takaya, Hiroaki, Kaji, Kosuke, Kawaratani, Hideto, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

“…Objecive Patients with autoimmune hepatitis (AIH) reportedly have an impaired quality of life (QOL), mainly due to depression, even during remission. In…”
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Association between Equol Production Status and Nonalcoholic Steatohepatitis by Akahane, Takemi, Kaya, Daisuke, Noguchi, Ryuichi, Kaji, Kosuke, Miyakawa, Haruna, Fujinaga, Yukihisa, Tsuji, Yuki, Takaya, Hiroaki, Sawada, Yasuhiko, Furukawa, Masanori, Kitagawa, Koh, Ozutsumi, Takahiro, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Yoshiji, Hitoshi

“…Equol is a metabolite of daidzein, a major soybean isoflavone with estrogenic and antioxidant activities. As the production of equol depends on the presence of…”
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Angiotensin Receptor Blockers Potentiate the Protective Effect of Branched‐Chain Amino Acids on Skeletal Muscle Atrophy in Cirrhotic Rats by Takeda, Soichi, Kaji, Kosuke, Nishimura, Norihisa, Enomoto, Masahide, Fujimoto, Yuki, Murata, Koji, Takaya, Hiroaki, Kawaratani, Hideto, Moriya, Kei, Namisaki, Tadashi, Akahane, Takemi, Yoshiji, Hitoshi

“…Scope This study investigated the combined effect of the angiotensin II (AT‐II) receptor blocker losartan and branched‐chain amino acids (BCAAs) on skeletal…”
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The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration by Bae, Woo Kyun, Kang, Keunsoo, Yu, Ji Hoon, Yoo, Kyung Hyun, Factor, Valentina M., Kaji, Kosuke, Matter, Matthias, Thorgeirsson, Snorri, Helmighausen, Lothar

“…ABSTRACT To investigate the role of enhancer of zeste homolog (EZH) 1 and EZH2 in liver homeostasis, mice were generated that carried Ezh1‐/‐ and EZH2fl/fl…”
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