Search Results - "Kosugi, Kaori"
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Biomimetic aorta-gonad-mesonephros-on-a-chip to study human developmental hematopoiesis
Published in Biomedical microdevices (06-05-2020)“…A fundamental limitation in the derivation of hematopoietic stem and progenitor cells is the imprecise understanding of human developmental hematopoiesis…”
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Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes
Published in ACS biomaterials science & engineering (09-08-2021)“…A liver-on-a-chip (liver-chip) is a microfluidic device carrying liver cells such as human hepatocytes. It is used to reproduce a part of liver function. Many…”
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Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips
Published in PNAS nexus (01-03-2023)“…SARS-CoV-2 induces severe organ damage not only in the lung but also in the liver, heart, kidney, and intestine. It is known that COVID-19 severity correlates…”
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Generation of Tetrafluoroethylene–Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies
Published in ACS omega (28-09-2021)“…Polydimethylsiloxane (PDMS) is widely used to fabricate microfluidic organs-on-chips. Using these devices (PDMS-based devices), the mechanical microenvironment…”
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SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression
Published in Science advances (23-09-2022)“…In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial…”
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