Molecular Targets of Natriuretic Action of Prolactin in the Rat Model of Cholestasis of Pregnancy

We analyzed the expression of molecular targets of natriuretic action of prolactin in different layers of the kidney in the rat model of cholestasis of pregnancy. Sodium bicarbonate cotransporter NBCe1 was most sensitive to the conditions of cholestasis and cholestasis of pregnancy: the expression N...

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Published in:	Bulletin of experimental biology and medicine Vol. 168; no. 2; pp. 219 - 223
Main Authors:	Abramicheva, P. A., Kostenko, Yu. B., Balakina, T. A., Smirnova, O. V.
Format:	Journal Article
Language:	English
Published:	New York Springer US 01-12-2019 Springer
Subjects:	Animals Biomedical and Life Sciences Biomedicine Carbonates Cell Biology Cholestasis Cholestasis - pathology Disease Models, Animal Epithelial Sodium Channels - biosynthesis Epithelial Sodium Channels - genetics Female Internal Medicine Ion Transport - physiology Jaundice, Obstructive Kidney Medulla - metabolism Laboratory Medicine Ligases Nedd4 Ubiquitin Protein Ligases - biosynthesis Nedd4 Ubiquitin Protein Ligases - genetics Pathology Pregnancy Prolactin Prolactin - metabolism Rats RNA RNA, Messenger - biosynthesis Sodium-Bicarbonate Symporters - biosynthesis Sodium-Bicarbonate Symporters - genetics Solute Carrier Family 12, Member 3 - biosynthesis Solute Carrier Family 12, Member 3 - genetics Ubiquitin Water-Electrolyte Balance - physiology cholestasis of pregnancy NBCe1 kidney prolactin NCC
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Summary:	We analyzed the expression of molecular targets of natriuretic action of prolactin in different layers of the kidney in the rat model of cholestasis of pregnancy. Sodium bicarbonate cotransporter NBCe1 was most sensitive to the conditions of cholestasis and cholestasis of pregnancy: the expression NBCe1 mRNA and protein in the renal outer medulla decreased in comparison with the normal. All forms of cholestasis affected the mRNA expression of sodium-potassium chloride co-transporter NCC, α-subunit of the ENaCα epithelial sodium channel, and Nedd4-2 ubiquitin ligase in different layers of the kidney. The obtained data suggest that prolactin provides fine tuning of various sodium transporters in different parts of the nephron under pathological conditions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-019-04678-8