Search Results - "Kossor, David C."

Administration of the oral antibiotic frenolicin-B selectively alters copper nutriture in male rats by Kossor, D C, Han, S, Kemp, F W, Slauter, R W, Serota, D, Rajaskarian, D, Milner, N, Davidovich, A, Bogden, J D

“…The polyketide antibiotic Frenolicin-B (FB) produces anorexia and esophageal epithelial hyperplasia (EH) in rats, findings that are characteristic of zinc…”
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Adrenal activation of carbon tetrachloride: role of microsomal P450 isozymes by Colby, H D, Purcell, H, Kominami, S, Takemori, S, Kossor, D C

“…Previous investigations demonstrated that carbon tetrachloride (CCl4) was activated by adrenal microsomes, resulting in various functional changes and…”
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Assessment of hepatobiliary function in vivo and ex vivo in the rat by Handler, J A, Kossor, D C, Goldstein, R S

“…Many xenobiotics cause hepatobiliary toxicity and cholestasis in the rat. Initial assessment of hepatobiliary damage in rats can be accomplished by measuring…”
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Dose-dependent actions of spironolactone on the inner and outer zones of the guinea pig adrenal cortex by Kossor, D C, Colby, H D

“…The results of prior in vitro studies indicated that spironolactone (SL) caused far greater degradation of cytochromes P-450 in the outer (zona glomerulosa…”
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Bile Duct Obstruction Is not a Prerequisite for Type I Biliary Epithelial Cell Hyperplasia by Kossor, David C., Meunier, Paul C., Dulik, Deanne M., Leonard, Thomas B., Goldstein, Robin S.

“…Biliary obstruction, produced by common bile duct ligation or α-naphthylisothiocyanate (ANIT) treatment in rats, has been associated with the development of…”
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Role of the steroid 17 alpha-hydroxylase in spironolactone-mediated destruction of adrenal cytochrome P-450 by Kossor, D C, Kominami, S, Takemori, S, Colby, H D

“…Previous investigations have established that spironolactone (SL) is converted to a reactive metabolite by adrenal microsomal enzymes, resulting in the…”
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Cholestatic potentials of alpha-naphthylisothiocyanate (ANIT) and beta-naphthylisothiocyanate (BNIT) in the isolated perfused rat liver by Kossor, D C, Handler, J A, Dulik, D M, Meunier, P C, Leonard, T B, Goldstein, R S

“…Previous studies in rats have shown that a single oral dose of alpha-naphthylisothiocyanate (ANIT), but not the regioisomer beta-naphthylisothiocyanate (BNIT),…”
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Destruction of testicular cytochrome P-450 by 7 alpha-thiospironolactone is catalyzed by the 17 alpha-hydroxylase by Kossor, D C, Kominami, S, Takemori, S, Colby, H D

“…Studies were done to determine the role of the 17 alpha-hydroxylase in the conversion of 7 alpha-thiospironolactone (7 alpha-thio-SL) to a reactive metabolite…”
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Relationship between covalent binding to microsomal protein and the destruction of adrenal cytochrome P-450 by spironolactone by Colby, H D, O'Donnell, J P, Flowers, N L, Kossor, D C, Johnson, P B, Levitt, M

“…Previous investigations have demonstrated that guinea pig adrenal microsomes catalyze an NADPH-dependent activation of spironolactone (SL) resulting in the…”
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Possible role of hydroxyl radicals in the metabolism of succinonitrile by Hayes, E P, Freeman, J J, Kossor, D C

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Biliary epithelial cell proliferation following alpha-naphthylisothiocyanate (ANIT) treatment: relationship to bile duct obstruction by Kossor, D C, Goldstein, R S, Ngo, W, DeNicola, D B, Leonard, T B, Dulik, D M, Meunier, P C

“…These studies were designed to evaluate the importance of bile duct obstruction in the pathogenesis of alpha-naphthylisothiocyanate (ANIT)-induced biliary…”
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