Search Results - "Kossmann, M."

Early management of severe traumatic brain injury by Rosenfeld, Jeffrey V, Prof, Maas, Andrew I, Prof, Bragge, Peter, PhD, Morganti-Kossmann, M Cristina, PhD, Manley, Geoffrey T, Prof, Gruen, Russell L, Prof

“…Summary Severe traumatic brain injury remains a major health-care problem worldwide. Although major progress has been made in understanding of the…”
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Role of CCL2 (MCP-1) in traumatic brain injury (TBI): evidence from severe TBI patients and CCL2− − mice by Semple, Bridgette D, Bye, Nicole, Rancan, Mario, Ziebell, Jenna M, Morganti-Kossmann, M Cristina

“…Cerebral inflammation involves molecular cascades contributing to progressive damage after traumatic brain injury (TBI). The chemokine CC ligand-2 (CCL2)…”
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Animal models of traumatic brain injury: Is there an optimal model to reproduce human brain injury in the laboratory? by Morganti-Kossmann, M.C, Yan, E, Bye, N

“…Abstract Compared to other neurological diseases, the research surrounding traumatic brain injury (TBI) has a more recent history. The establishment and use of…”
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Temporal proteomics of human cerebrospinal fluid after severe traumatic brain injury by Shultz, Sandy R, Shah, Anup D, Huang, Cheng, Dill, Larissa K, Schittenhelm, Ralf B, Morganti-Kossmann, M Cristina, Semple, Bridgette D

“…The pathophysiology of traumatic brain injury (TBI) requires further characterization to fully elucidate changes in molecular pathways. Cerebrospinal fluid…”
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Characterising effects of impact velocity on brain and behaviour in a model of diffuse traumatic axonal injury by Yan, E.B, Johnstone, V.P.A, Alwis, D.S, Morganti-Kossmann, M.-C, Rajan, R

“…Highlights • Impact velocity is a critical factor that determines brain injury outcomes. • WDIA model of brain injury can be altered to deliver different…”
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Neurogenesis and glial proliferation are stimulated following diffuse traumatic brain injury in adult rats by Bye, Nicole, Carron, Sarah, Han, Xiaodi, Agyapomaa, Doreen, Ng, Si Yun, Yan, Edwin, Rosenfeld, Jeffrey V., Morganti-Kossmann, M. Cristina

“…Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI…”
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Post-traumatic hypoxia exacerbates neurological deficit, neuroinflammation and cerebral metabolism in rats with diffuse traumatic brain injury by Yan, Edwin B, Hellewell, Sarah C, Bellander, Bo-Michael, Agyapomaa, Doreen A, Morganti-Kossmann, M Cristina

“…The combination of diffuse brain injury with a hypoxic insult is associated with poor outcomes in patients with traumatic brain injury. In this study, we…”
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Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury by Semple, Bridgette D, Bye, Nicole, Ziebell, Jenna M, Morganti-Kossmann, M. Cristina

“…Abstract The contribution of infiltrated neutrophils to secondary damage following traumatic brain injury remains controversial. Chemokines that regulate…”
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Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor by Hellewell, Sarah C, Yan, Edwin B, Alwis, Dasuni S, Bye, Nicole, Morganti-Kossmann, M Cristina

“…Diffuse axonal injury is a common consequence of traumatic brain injury (TBI) and often co-occurs with hypoxia, resulting in poor neurological outcome for…”
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Post-traumatic hypoxia exacerbates brain tissue damage: analysis of axonal injury and glial responses by Hellewell, Sarah C, Yan, Edwin B, Agyapomaa, Doreen A, Bye, Nicole, Morganti-Kossmann, M Cristina

“…Traumatic brain injury (TBI) resulting in poor neurological outcome is predominantly associated with diffuse brain damage and secondary hypoxic insults…”
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Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice by Ng, Si Yun, Semple, Bridgette D, Morganti-Kossmann, M Cristina, Bye, Nicole

“…Neurogenesis is stimulated following injury to the adult brain and could potentially contribute to tissue repair. However, evidence suggests that microglia…”
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CCL2 modulates cytokine production in cultured mouse astrocytes by Semple, Bridgette D, Frugier, Tony, Morganti-Kossmann, M Cristina

“…The chemokine CCL2 (also known as monocyte chemoattractant protein-1, or MCP-1) is upregulated in patients and rodent models of traumatic brain injury (TBI),…”
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Transient neuroprotection by minocycline following traumatic brain injury is associated with attenuated microglial activation but no changes in cell apoptosis or neutrophil infiltration by Bye, Nicole, Habgood, Mark D., Callaway, Jennifer K., Malakooti, Nakisa, Potter, Ann, Kossmann, Thomas, Morganti-Kossmann, M. Cristina

“…Cerebral inflammation and apoptotic cell death are two processes implicated in the progressive tissue damage that occurs following traumatic brain injury…”
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Impact Acceleration Model of Diffuse Traumatic Brain Injury by Hellewell, Sarah C, Ziebell, Jenna M, Lifshitz, Jonathan, Morganti-Kossmann, M Cristina

“…The impact acceleration (I/A) model of traumatic brain injury (TBI) was developed to reliably induce diffuse traumatic axonal injury in rats in the absence of…”
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Skin Examination: An Important Diagnostic Tool in Renal Failure Patients by Van de Velde-Kossmann, Karen M

“…Renal failure is common in the United States with an estimated prevalence of 660,000 treated end-stage renal disease patients in 2015 [<xref ref-type="bibr"…”
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The duality of the inflammatory response to traumatic brain injury by Lenzlinger, P M, Morganti-Kossmann, M C, Laurer, H L, McIntosh, T K

“…One and a half to two million people sustain a traumatic brain injury (TBI) in the US each year, of which approx 70,000-90,000 will suffer from long-term…”
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Endogenous melatonin increases in cerebrospinal fluid of patients after severe traumatic brain injury and correlates with oxidative stress and metabolic disarray by Seifman, Marc A, Adamides, Alexios A, Nguyen, Phuong N, Vallance, Shirley A, Cooper, David James, Kossmann, Thomas, Rosenfeld, Jeffrey V, Morganti-Kossmann, M Cristina

“…Oxidative stress plays a significant role in secondary damage after severe traumatic brain injury (TBI); and melatonin exhibits both direct and indirect…”
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Inflammatory Regulators of Redirected Neural Migration in the Injured Brain by Bye, Nicole, Turnley, Ann M., Morganti-Kossmann, M. Cristina

“…Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged…”
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Phosphate Sensing by Fluorescent Reporter Proteins Embedded in Polyacrylamide Nanoparticles by Sun, Honghao, Scharff-Poulsen, Anne Marie, Gu, Hong, Jakobsen, Iver, Kossmann, Jens M, Frommer, Wolf B, Almdal, Kristoffer

“…Phosphate sensors were developed by embedding fluorescent reporter proteins (FLIPPi) in polyacrylamide nanoparticles with diameters from 40 to 120 nm. The…”
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The Complex and Diversified Mitochondrial Gene Pool of Berber Populations by Coudray, C., Olivieri, A., Achilli, A., Pala, M., Melhaoui, M., Cherkaoui, M., El‐Chennawi, F., Kossmann, M., Torroni, A., Dugoujon, J. M.

“…Summary The mitochondrial DNA variation of 295 Berber‐speakers from Morocco (Asni, Bouhria and Figuig) and the Egyptian oasis of Siwa was evaluated by…”
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