Search Results - "Kossar, Alexander"

Bacterial infiltration and bioprosthetic valve failure: Emerging diagnostics for emerging therapies by Kossar, Alexander P., George, Isaac, Gordon, Rachel, Ferrari, Giovanni

“…Profile (A) and inflow surface (B) of an explanted TAVR bioprosthesis with structural degeneration and endocarditis (reprinted with permission from Seeburger…”
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Aortic Root Replacement for a TAVR-Induced Aortic Root–to–Right Ventricular Fistula by Kossar, Alexander P., Ravalli, Filippo, George, Isaac, Ferrari, Giovanni, Takayama, Hiroo

“…Aortic right ventricular fistulae have been thoroughly documented as a rare but potentially serious complication of surgical aortic valve replacement. The risk…”
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Noncalcific Mechanisms of Bioprosthetic Structural Valve Degeneration by Marro, Matteo, Kossar, Alexander P, Xue, Yingfei, Frasca, Antonio, Levy, Robert J, Ferrari, Giovanni

“…Bioprosthetic heart valves (BHVs) largely circumvent the need for long-term anticoagulation compared with mechanical valves but are increasingly susceptible to…”
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A biomimetic multilayered polymeric material designed for heart valve repair and replacement by Sun, Mingze, Elkhodiry, Mohamed, Shi, Lei, Xue, Yingfei, Abyaneh, Maryam H., Kossar, Alexander P., Giuglaris, Caroline, Carter, Samuel L., Li, Richard L., Bacha, Emile, Ferrari, Giovanni, Kysar, Jeffrey, Myers, Kristin, Kalfa, David

“…Materials currently used to repair or replace a heart valve are not durable. Their limited durability related to structural degeneration or thrombus formation…”
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Age-related enhanced degeneration of bioprosthetic valves due to leaflet calcification, tissue crosslinking, and structural changes by Xue, Yingfei, Kossar, Alexander P, Abramov, Alexey, Frasca, Antonio, Sun, Mingze, Zyablitskaya, Mariya, Paik, David, Kalfa, David, Della Barbera, Mila, Thiene, Gaetano, Kozaki, Satoshi, Kawashima, Takayuki, Gorman, Joseph H, Gorman, Robert C, Gillespie, Matthew J, Carreon, Chrystalle Katte, Sanders, Stephen P, Levy, Robert J, Ferrari, Giovanni

“…Abstract Aims Bioprosthetic heart valves (BHVs), made from glutaraldehyde-fixed heterograft materials, are subject to more rapid structural valve degeneration…”
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Comparative pathology of human and canine myxomatous mitral valve degeneration: 5HT and TGF-β mechanisms by Oyama, Mark A., Elliott, Chad, Loughran, Kerry A., Kossar, Alexander P., Castillero, Estibaliz, Levy, Robert J., Ferrari, Giovanni

“…Myxomatous mitral valve degeneration (MMVD) is a leading cause of valve repair or replacement secondary to the production of mitral regurgitation, cardiac…”
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Direct access valve‐in‐valve implantation for management of complex valvulopathy by Kossar, Alexander P., Borger, Michael, George, Isaac

“…The management of bioprosthetic structural valve degeneration requires complex surgical or transcatheter re‐intervention for which many high‐risk patients are…”
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Assessing sex-based differences in postsurgical clinical outcomes after use of del Nido cardioplegia by Honzel, Emily, Nemeth, Samantha, Kazzi, Brigitte E, Kossar, Alexander P, Sun, Jocelyn, Kaku, Yuji, Takeda, Koji, Takayama, Hiroo, Argenziano, Michael, Spellman, Jessica, Miltiades, Andrea, Fung, Kenmond, Beck, James, Smith, Craig R, Kurlansky, Paul, George, Isaac

“…del Nido cardioplegia is used to pharmacologically arrest the heart during cardiac surgery and decrease reperfusion- and ischaemia-related myocardial injury…”
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In Vitro Proof of Concept of a First‐Generation Growth‐Accommodating Heart Valved Conduit for Pediatric Use by Li, Richard L., Sun, Mingze, Russ, Jonathan B., Pousse, Pierre‐Louis, Kossar, Alexander P., Gibson, Isabel, Paschalides, Costas, Herschman, Abigail R., Abyaneh, Maryam H., Ferrari, Giovanni, Bacha, Emile, Waisman, Haim, Vedula, Vijay, Kysar, Jeffrey W., Kalfa, David

“…Currently available heart valve prostheses have no growth potential, requiring children with heart valve diseases to endure multiple valve replacement…”
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Novel Implementation of a Cerebral Protection System During Ascending Thoracic Endovascular Aortic Repair (TEVAR) by Kossar, Alexander P., Takayama, Hiroo, Patel, Virendra, George, Isaac

“…TEVAR of the ascending aorta is associated with increased risk of stroke, which may be mitigated by use of cerebral protective devices. Sentinel Cerebral…”
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Bringing prevost's sign into the third dimension: Artificial intelligence estimation of conjugate gaze adjusted length (CGAL) and correlation with acute ischemic stroke by Maresky, Hillel S., Rootman, Joseph M., Klar, Miriam M., Levitt, Max, Kossar, Alexander P., Zucker, David, Glazier, Michael, Kalmanovich-Avnery, Shani, Aviv, Richard, Ertl-Wagner, Birgit, Tal, Sigal

“…Conjugate gaze deviation is associated with acute ischemic stroke (AIS), although previously only measured on a 2D plane. The current study evaluates 3D…”
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Re-Dosing del Nido cardioplegia in adult cardiac surgery: Perfusion characteristics and outcomes--Is there an optimal redosing strategy? by Kossar, Alexander P, Nemeth, Samantha, Kosuri, Yaagnik D, Kazzi, Brigitte E, Honzel, Emily, D’Angelo, Alex, Spellman, Jessica, Takeda, Koji, Takayama, Hiroo, Bapat, Vinayak, Argenziano, Michael, Beck, James, Smith, Craig R, Kurlansky, Paul, George, Isaac

“…Objectives del Nido cardioplegia is utilized for myocardial protection in adult patients undergoing cardiac surgery; however, no standardized re-dosing…”
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Circulating and tissue matricellular RNA and protein expression in calcific aortic valve disease by Kossar, Alexander P, Anselmo, Wanda, Grau, Juan B, Liu, Yichuan, Small, Aeron, Carter, Samuel L, Salvador, Lisa, Zhao, Lei, Cvijic, Mary Ellen, Li, Zhuyin, Yarde, Melissa, Rioux, Nancy, Rader, Daniel J, Levy, Robert J, Ferrari, Giovanni

“…Aortic valve sclerosis is a highly prevalent, poorly characterized asymptomatic manifestation of calcific aortic valve disease and may represent a therapeutic…”
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Re-dosing of del Nido cardioplegia in adult cardiac surgery requiring prolonged aortic cross-clamp by D’Angelo, Alex M, Nemeth, Samantha, Wang, Catherine, Kossar, Alexander P, Takeda, Koji, Takayama, Hiroo, Bapat, Vinayak, Naka, Yoshifumi, Argenziano, Michael, Smith, Craig R, Beck, James, Spellman, Jessica, Kurlansky, Paul, George, Isaac

“…Abstract OBJECTIVES Few data exist on the use of del Nido cardioplegia in adults, specifically during operations requiring prolonged aortic cross-clamp. In…”
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Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves by Frasca, Antonio, Xue, Yingfei, Kossar, Alexander P., Keeney, Samuel, Rock, Christopher, Zakharchenko, Andrey, Streeter, Matthew, Gorman, Robert C., Grau, Juan B., George, Isaac, Bavaria, Joseph E., Krieger, Abba, Spiegel, David A., Levy, Robert J., Ferrari, Giovanni

“…[Display omitted] •Two novel and interacting mechanisms contributing to BHV SVD are reported: glycation and serum albumin infiltration.•Glycation product…”
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Aortic Valve Regurgitation: Pathophysiology and Implications for Surgical Intervention in the Era of TAVR by Ravalli, Filippo, Kossar, Alexander P., Takayama, Hiroo, Grau, Juan B., Ferrari, Giovanni

“…Aortic regurgitation (AR) or insufficiency is caused by the malcoaptation of the aortic valve (AV) cusps due to intrinsic abnormalities of the valve itself, a…”
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Acute Kidney Injury Following Surgical Aortic Valve Replacement by Najjar, Marc, Yerebakan, Halit, Sorabella, Robert A., Donovan, Denis J., Kossar, Alexander P., Sreekanth, Sowmyashree, Kurlansky, Paul, Borger, Michael A., Argenziano, Michael, Smith, Craig R., George, Isaac

“…Background Acute kidney injury (AKI) is a significant complication of surgical aortic valve replacement (SAVR). This study sought to describe AKI following…”
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Bridging cardiogenic shock patients with short-term ventricular support at a community hospital to long-term ventricular support at a tertiary hospital by González-Costello, José, MD, Yang, Jonathan, MD, Sims, Daniel B., MD, Kossar, Alexander P, Murray, Lindsay K., BA, Colombo, Paolo C., MD, Takayama, Hiroo, MD, Mancini, Donna, MD, Naka, Yoshifumi, MD, PhD, Jorde, Ulrich P., MD, Uriel, Nir, MD

“…Background Patients in cardiogenic shock require immediate circulatory support. Outcomes of patients who underwent short-term ventricular assist device (STVAD)…”
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Gather: An Innovative Tool for Residency Pre-Interview Events by Sathe, Tejas S, Krimbill, Jacob R, Kossar, Alexander

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Abstract 15601: On the Mechanisms of Accelerated Calcification of Bioprosthetic Heart Valve Biomaterials in Juvenile Animal Models by Xue, Yingfei, Kossar, Alexander, THIENE, Gaetano, LEVY, Robert, Ferrari, Giovanni

“…ObjectiveBioprosthetic heart valves (BHV) are subject to accelerated structural valve degeneration (SVD) in pediatric patients. Prior literature has reported…”
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