Search Results - "Koss, Konrad"

Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening：A meta-analysis by Tonus, Carolin, Sellinger, Markus, Koss, Konrad, Neupert, Gero

“…AIM：To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2（faecal M2-PK） test for colorectal cancer（CRC） screening…”
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The UK‐PBC risk scores: Derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis by Paximadas, Dimitrios, Trembling, Paul, Heneghan, Michael A., Neuberger, James M., Hirschfield, Gideon M., Sandford, Richard N., Mells, George F., Alexander, Graeme, Sandford, Richard, Taylor‐Robinson, Simon, Czajkowski, Marek, Gyawali, Pranab, Marley, Richard, Foster, Graham, Subhani, Javaid, Gasem, Jaber, Mathialahan, Thiriloganathan, Shorrock, Christopher, Lipscomb, George, Tibble, Jeremy, Gorard, David, Dawwas, Mohamed, Mitchison, Harriet, Sayer, Joanna, Hankey, Lorraine, Koss, Konrad, Brown, Jonathan, Gordon, Harriet, Salam, Imroz, Narain, Mark, Taylor‐Robinson, Simon, Grellier, Leonie, Das, Debashis, Jones, Rebecca, Bird, George, Kitchen, Paul, Yoong, Kevin, MacFaul, George, Fraser, Andrew, Dillon, John, Shmueli, Udi, Naqvi, Asifabbas, Lee, Tom, Ryder, Stephen D., Sharer, Nicholas, Aspinall, Richard, Hussaini, Hyder, Ayres, Reuben, Marshall, Eileen, Butterworth, Jeff, Shearman, Jeremy, Bray, Gary, Das, Debashis, Wright, Mark, Collins, Carole, Whalley, Simon, Li, Andy, Wong, Voi Shim, Ransford, Rupert, Millson, Charles, Harrison, Melanie, Mulvaney‐Jones, Caroline, Loftus, Alison, Damant, Rose, Desousa, Phillipa, McKay, Alexandra, Tan, LaiTing, Flahive, Kerry, Ford, Chris, MacNicol, Carolyn, Wilkins, Joy, Young, Karin, Martin, Kirsty, Tanqueray, Elizabeth, Morrison, Jennifer, Slininger, Susan, Ainsworth, Mark, Lord, Susan, Longhurst, Beverley, Hayes, Maria, Shpuza, Ervin, Gunter, Emma, Dewhurst, Hannah, Leoni, Marina, Tyrer, David, Dali‐kemmery, Lola, Lambourne, Victoria, Shinder, Bal, Mills, Marisa, Brown, Carly, Archer, Emily, Mupudzi, Mcdonald, Batham, Sally, Conder, Jill, Orpe, Jacky, Currie, Lynn, Amey, Isobel, Cumlat, Lourdes, Winter, Louise, Sweeting, Helen

“…The biochemical response to ursodeoxycholic acid (UDCA)—so‐called “treatment response”—strongly predicts long‐term outcome in primary biliary cholangitis…”
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GWAS meta-analysis of 16 790 patients with Barrett's oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level by Schröder, Julia, Chegwidden, Laura, Maj, Carlo, Gehlen, Jan, Speller, Jan, Böhmer, Anne C, Borisov, Oleg, Hess, Timo, Kreuser, Nicole, Venerito, Marino, Alakus, Hakan, May, Andrea, Gerges, Christian, Schmidt, Thomas, Thieme, Rene, Heider, Dominik, Hillmer, Axel M, Reingruber, Julian, Lyros, Orestis, Dietrich, Arne, Hoffmeister, Albrecht, Mehdorn, Matthias, Lordick, Florian, Stocker, Gertraud, Hohaus, Michael, Reim, Daniel, Kandler, Jennis, Müller, Michaela, Ebigbo, Alanna, Fuchs, Claudia, Bruns, Christiane J, Hölscher, Arnulf H, Lang, Hauke, Grimminger, Peter P, Dakkak, Dani, Vashist, Yogesh, May, Sandra, Görg, Siegfried, Franke, Andre, Ellinghaus, David, Galavotti, Sara, Veits, Lothar, Weismüller, Josef, Dommermuth, Jens, Benner, Udo, Rösch, Thomas, Messmann, Helmut, Schumacher, Brigitte, Neuhaus, Horst, Schmidt, Carsten, Wissinowski, Thaddäus T, Nöthen, Markus M, Dong, Jing, Ong, Jue-Sheng, Buas, Matthew F, Thrift, Aaron P, Vaughan, Thomas L, Tomlinson, Ian, Whiteman, David C, Fitzgerald, Rebecca Claire, Jankowski, Janusz, Vieth, Michael, Mayr, Andreas, Gharahkhani, Puya, MacGregor, Stuart, Gockel, Ines, Palles, Claire, Schumacher, Johannes

“…Oesophageal cancer (EC) is the sixth leading cause of cancer-related deaths. Oesophageal adenocarcinoma (EA), with Barrett's oesophagus (BE) as a precursor…”
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IBD BioResource: an open-access platform of 25 000 patients to accelerate research in Crohn's and Colitis by Parkes, Miles

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Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus by Gay, Laura J, Palles, Claire, Band, Gavin, Whiteman, David C, Lescai, Francesco, Langford, Cordelia, Nanji, Manoj, Edkins, Sarah, van der Winkel, Anouk, Sasieni, Peter, Howarth, Kimberley, Pirinen, Matti, Peppelenbosch, Maikel P, Kuipers, Ernst J, Peters, Wilbert H, Reynolds, John V, Kelleher, Dermot P, McManus, Ross, Grabsch, Heike, Prenen, Hans, Krishnadath, Kausila, Siersema, Peter D, van Baal, Jantine W P M, Middleton, Mark, Petty, Russell, Burch, Nicola, Bhandari, Pradeep, Edwards, Cathryn, Penman, Ian, Murray, Iain, Mullins, Paul, Wu, Anna H, Bird, Nigel C, Dallal, Helen, Shaheen, Nicholas J, Bernstein, Leslie, Corley, Douglas A, Reid, Brian J, Gammon, Marilie D, Smart, Howard, Dhar, Anjan, McMurtry, Hugh, Ali, Haythem, Liu, Geoffrey, Rutter, Matt, Tawil, Ashref, Morris, Danielle, Nwokolo, Chuka, Isaacs, Peter, Rodgers, Colin, Ragunath, Krish, MacDonald, Chris, Monk, David, Wajed, Saj, Johnston, David, Gibbons, Michael, Church, Nicholas, Langley, Ruth, Griffin, Michael, Alderson, Derek, Hunt, Sarah E, Gray, Emma, Dronov, Serge, Potter, Simon C, Tashakkori-Ghanbaria, Avazeh, Brooks, Claire, Bramon, Elvira, Brown, Matthew A, Casas, Juan P, Corvin, Aiden, Duncanson, Audrey, Markus, Hugh S, Mathew, Christopher G, Palmer, Colin N A, Plomin, Robert, Rautanen, Anna, Trembath, Richard C, Viswanathan, Ananth C, Wood, Nicholas, Trynka, Gosia, Wijmenga, Cisca, Cazier, Jean-Baptiste, Gellatly, Nichola L, Glancy, Deborah, Cooper, Sheldon C, Cunningham, David, Hapeshi, Julie, Ferry, David, Rathbone, Barrie, MacGregor, Stuart, Watson, Peter, Sanders, Scott, Ek, Weronica, Harrison, Rebecca F, de Caestecker, John, Barr, Hugh, Vaughan, Thomas L, Peltonen, Leena, Spencer, Chris C A, Jankowski, Janusz A Z

“…Peter Donnelly and colleagues report a genome-wide association study for Barrett's esophagus, a common premalignant condition associated with stomach acid…”
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Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus by Palles, Claire, Chegwidden, Laura, Li, Xinzhong, Findlay, John M, Farnham, Garry, Castro Giner, Francesc, Peppelenbosch, Maikel P, Kovac, Michal, Adams, Claire L, Prenen, Hans, Briggs, Sarah, Harrison, Rebecca, Sanders, Scott, MacDonald, David, Haigh, Chris, Tucker, Art, Love, Sharon, Nanji, Manoj, deCaestecker, John, Ferry, David, Rathbone, Barrie, Hapeshi, Julie, Barr, Hugh, Moayyedi, Paul, Watson, Peter, Zietek, Barbara, Maroo, Neera, Gay, Laura, Underwood, Tim, Boulter, Lisa, McMurtry, Hugh, Monk, David, Patel, Praful, Ragunath, Krish, Al Dulaimi, David, Murray, Iain, Koss, Konrad, Veitch, Andrew, Trudgill, Nigel, Nwokolo, Chuka, Rembacken, Bjorn, Atherfold, Paul, Green, Elaine, Ang, Yeng, Kuipers, Ernst J, Chow, Wu, Paterson, Stuart, Kadri, Sudarshan, Beales, Ian, Grimley, Charles, Mullins, Paul, Beckett, Conrad, Farrant, Mark, Dixon, Andrew, Kelly, Sean, Johnson, Matthew, Wajed, Shahjehan, Dhar, Anjan, Sawyer, Elinor, Roylance, Rebecca, Onstad, Lynn, Gammon, Marilie D, Corley, Douglas A, Shaheen, Nicholas J, Bird, Nigel C, Hardie, Laura J, Reid, Brian J, Ye, Weimin, Liu, Geoffrey, Romero, Yvonne, Bernstein, Leslie, Wu, Anna H, Casson, Alan G, Fitzgerald, Rebecca, Whiteman, David C, Risch, Harvey A, Levine, David M, Vaughan, Tom L, Verhaar, Auke P, van den Brande, Jan, Toxopeus, Eelke L, Spaander, Manon C, Wijnhoven, Bas P.L, van der Laan, Luc J.W, Krishnadath, Kausilia, Wijmenga, Cisca, Trynka, Gosia, McManus, Ross, Reynolds, John V, O’Sullivan, Jacintha, MacMathuna, Padraic, McGarrigle, Sarah A, Kelleher, Dermot, Vermeire, Severine, Cleynen, Isabelle, Bisschops, Raf, Tomlinson, Ian, Jankowski, Janusz

“…Background & Aims Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found the risk to be BE has been associated with single…”
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Biologic Therapy for Inflammatory Bowel Disease: Real-World Comparative Effectiveness and Impact of Drug Sequencing in 13 222 Patients within the UK IBD BioResource by Kapizioni, Christina, Desoki, Rofaida, Lam, Danielle, Balendran, Karthiha, Al-Sulais, Eman, Subramanian, Sreedhar, Rimmer, Joanna E, De La Revilla Negro, Juan, Pavey, Holly, Pele, Laetitia, Brooks, Johanne, Moran, Gordon W, Irving, Peter M, Limdi, Jimmy K, Lamb, Christopher A, Parkes, Miles, Raine, Tim

“…Abstract Background and Aims This study compares the effectiveness of different biologic therapies and sequences in patients with inflammatory bowel disease…”
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Faecal dimeric M2 pyruvate kinase in colorectal cancer and polyps correlates with tumour staging and surgical intervention by Koss, K., Maxton, D., Jankowski, J. A. Z.

“…Objective & Method  A dimeric form of pyruvate kinase isoenzyme (tumour M2‐PK) is predominantly found in highly proliferating cells. Sandwich ELISA with…”
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Cytokine (TNF alpha, LT alpha and IL-10) polymorphisms in inflammatory bowel diseases and normal controls: differential effects on production and allele frequencies by Koss, K, Satsangi, J, Fanning, G C, Welsh, K I, Jewell, D P

“…The influence of biallelic polymorphisms in the tumour necrosis factor-alpha (TNF alpha), lymphotoxin-alpha (LT alpha) and interleukin-10 (IL-10) genes on…”
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The effect of smoking on IL-10, TNFa and IL-6 production in Crohn's disease by Koss, Konrad, Jewell, Derek P.

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Interleukin-10 gene promoter polymorphism in English and Polish healthy controls. Polymerase chain reaction haplotyping using 3' mismatches in forward and reverse primers by Koss, K, Fanning, G C, Welsh, K I, Jewell, D P

“…A polymerase chain reaction with sequence-specific primers (PCR-SSP) system using primers with mismatches at the 3' ends was developed to determine…”
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The presence of anti-neutrophil antibodies reflects clinical and genetic heterogeneity within inflammatory bowel disease by Satsangi, J, Landers, C J, Welsh, K I, Koss, K, Targan, S, Jewell, D P

“…A detailed investigation of the relationship between anti-neutrophil cytoplasmic antibodies (ANCA) status, HLA genotype, and clinical patterns of inflammatory…”
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Is interleukin-6 important in inflammatory bowel disease? by Koss, K, Satsangi, J, Welsh, K I, Jewell, D P

“…The IL-6 gene maps to an area of chromosome 7 known to be significant for susceptibility to inflammatory bowel disease. The functional effects of interleukin-6…”
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The presence of anti‐neutrophil antibodies reflects clinical and genetic heterogeneity within inflammatory bowel disease by Satsangi, Jack, Landers, Carol J., Welsh, Ken I., Koss, Konrad, Targan, Stephan, Jewell, Derek P.

“…A detailed investigation of the relationship between anti‐neutrophil cytoplasmic antibodies (ANCA) status, HLA genotype, and clinical patterns of inflammatory…”
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