Search Results - "Koss, David J."

Dementia with Lewy bodies: an update and outlook by Outeiro, Tiago Fleming, Koss, David J, Erskine, Daniel, Walker, Lauren, Kurzawa-Akanbi, Marzena, Burn, David, Donaghy, Paul, Morris, Christopher, Taylor, John-Paul, Thomas, Alan, Attems, Johannes, McKeith, Ian

“…Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and…”
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Dysfunction of RAB39B‐Mediated Vesicular Trafficking in Lewy Body Diseases by Koss, David J., Campesan, Susanna, Giorgini, Flaviano, Outeiro, Tiago F.

“…Intracellular vesicular trafficking is essential for neuronal development, function, and homeostasis and serves to process, direct, and sort proteins, lipids,…”
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In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies by Marvian, Amir Tayaranian, Koss, David J., Aliakbari, Farhang, Morshedi, Dina, Outeiro, Tiago Fleming

“…Alpha‐synuclein (α‐Syn) is a central player in Parkinson's disease (PD) and in a spectrum of neurodegenerative diseases collectively known as…”
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Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology by Koss, Dave J, Robinson, Lianne, Drever, Benjamin D, Plucińska, Kaja, Stoppelkamp, Sandra, Veselcic, Peter, Riedel, Gernot, Platt, Bettina

“…Abstract Models of Tau pathology related to frontotemporal dementia (FTD) are essential to determine underlying neurodegenerative pathologies and resulting…”
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Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies by Szegő, Éva M., Dominguez-Meijide, Antonio, Gerhardt, Ellen, König, Annekatrin, Koss, David J., Li, Wen, Pinho, Raquel, Fahlbusch, Christiane, Johnson, Mary, Santos, Patricia, Villar-Piqué, Anna, Thom, Tobias, Rizzoli, Silvio, Schmitz, Matthias, Li, Jiayi, Zerr, Inga, Attems, Johannes, Jahn, Olaf, Outeiro, Tiago F.

“…Alpha-synuclein (aSyn) accumulates in intracellular inclusions in synucleinopathies, but the molecular mechanisms leading to disease are unclear. We identify…”
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Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies by Koss, David J, Erskine, Daniel, Porter, Andrew, Palmoski, Pawel, Menon, Hariharan, Todd, Olivia G J, Leite, Marta, Attems, Johannes, Outeiro, Tiago F

“…Dementia with Lewy bodies (DLB) is pathologically defined by the cytoplasmic accumulation of alpha-synuclein (aSyn) within neurons in the brain. Predominately…”
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Therapeutic Targeting of Rab GTPases: Relevance for Alzheimer's Disease by Jordan, Kate L, Koss, David J, Outeiro, Tiago F, Giorgini, Flaviano

“…Rab GTPases (Rabs) are small proteins that play crucial roles in vesicle transport and membrane trafficking. Owing to their widespread functions in several…”
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Soluble pre-fibrillar tau and β-amyloid species emerge in early human Alzheimer’s disease and track disease progression and cognitive decline by Koss, David J., Jones, Glynn, Cranston, Anna, Gardner, Heidi, Kanaan, Nicholas M., Platt, Bettina

“…Post-mortem investigations of human Alzheimer’s disease (AD) have largely failed to provide unequivocal evidence in support of the original amyloid cascade…”
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Altered hippocampal doublecortin expression in Parkinson's disease by Plácido, Evelini, Koss, David J., Outeiro, Tiago Fleming, Brocardo, Patricia S.

“…Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by motor and non‐motor symptoms. Motor symptoms include bradykinesia, resting…”
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Distinctive temporal profiles of detergent-soluble and -insoluble tau and Aβ species in human Alzheimer’s disease by Koss, David J., Dubini, Marina, Buchanan, Heather, Hull, Claire, Platt, Bettina

“…•Two distinct phospho-dependent profiles of insoluble tau deposition are apparent.•Soluble tau and Aβ better correlate with AD progression than insoluble…”
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Synaptic Loss, ER Stress and Neuro-Inflammation Emerge Late in the Lateral Temporal Cortex and Associate with Progressive Tau Pathology in Alzheimer’s Disease by Buchanan, Heather, Mackay, Murray, Palmer, Kerri, Tothová, Karolína, Katsur, Miroslava, Platt, Bettina, Koss, David J.

“…The complex multifactorial nature of AD pathogenesis has been highlighted by evidence implicating additional neurodegenerative mechanisms, beyond that of…”
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Regional AT-8 reactive tau species correlate with intracellular Aβ levels in cases of low AD neuropathologic change by Malik, Nauman, Miah, Mohi-Uddin, Galgani, Alessandro, McAleese, Kirsty, Walker, Lauren, LeBeau, Fiona E., Attems, Johannes, Outeiro, Tiago F., Thomas, Alan, Koss, David J.

“…The amyloid cascade hypothesis states that Aβ aggregates induce pathological changes in tau, leading to neurofibrillary tangles (NFTs) and cell death. A caveat…”
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RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies by Koss, David J., Bondarevaite, Odeta, Adams, Sara, Leite, Marta, Giorgini, Flaviano, Attems, Johannes, Outeiro, Tiago F.

“…Loss of function mutations within the vesicular trafficking protein Ras analogy in brain 39B (RAB39B) are associated with rare X‐linked Parkinson’s disease…”
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Alzheimer's disease pathology and the unfolded protein response: prospective pathways and therapeutic targets by Koss, David J, Platt, Bettina

“…Many vital interdependent cellular functions including proteostasis, lipogenesis and Ca homeostasis are executed by the endoplasmic reticulum (ER). Exogenous…”
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Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia by Hull, Claire, Dekeryte, Ruta, Koss, David J., Crouch, Barry, Buchanan, Heather, Delibegovic, Mirela, Platt, Bettina

“…Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been…”
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Prion-like α-synuclein pathology in the brain of infants with Krabbe disease by Hatton, Christopher, Ghanem, Simona S, Koss, David J, Abdi, Ilham Y, Gibbons, Elizabeth, Guerreiro, Rita, Bras, Jose, Walker, Lauren, Gelpi, Ellen, Heywood, Wendy, Outeiro, Tiago F, Attems, Johannes, McFarland, Robert, Forsyth, Rob, El-Agnaf, Omar M, Erskine, Daniel

“…Krabbe disease is an infantile neurodegenerative disorder resulting from pathogenic variants in the GALC gene that causes accumulation of the toxic…”
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Age-dependent changes in hippocampal synaptic transmission and plasticity in the PLB1Triple Alzheimer mouse by Koss, David J, Drever, Benjamin D, Stoppelkamp, Sandra, Riedel, Gernot, Platt, Bettina

“…Several genetically engineered models exist that mimic aspects of the pathological and cognitive hallmarks of Alzheimer’s disease (AD). Here we report on a…”
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Store-operated Ca2+ entry in hippocampal neurons: Regulation by protein tyrosine phosphatase PTP1B by Koss, David J, Riedel, Gernot, Bence, Kendra, Platt, Bettina

“…Abstract Store operated Ca2+ entry (SOCE) replenishes intracellular Ca2+ stores and activates a number of intracellular signalling pathways. Whilst several…”
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Intracellular Ca2+ stores modulate SOCCs and NMDA receptors via tyrosine kinases in rat hippocampal neurons by Koss, David J, Riedel, Gernot, Platt, Bettina

“…Abstract The regulation of intracellular Ca2+ signalling by phosphorylation processes remains poorly defined, particularly with regards to tyrosine…”
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VALIDATION OF REPORTER ASSAYS FOR AMYLOID-B AGGREGATION by Jones, Glynn, Koss, David J, Riedel, Gernot, Platt, Bettina

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