Search Results - "Kosno, Michał"

Novel insights into conjugation of antitumor-active unsymmetrical bisacridine C-2028 with glutathione: Characteristics of non-enzymatic and glutathione S-transferase-mediated reactions by Potęga, Agnieszka, Kosno, Michał, Mazerska, Zofia

“…Unsymmetrical bisacridines (UAs) are a novel potent class of antitumor-active therapeutics. A significant route of phase II drug metabolism is conjugation with…”
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In Vitro Enzyme Kinetics and NMR-Based Product Elucidation for Glutathione S-Conjugation of the Anticancer Unsymmetrical Bisacridine C-2028 in Liver Microsomes and Cytosol: Major Role of Glutathione S-Transferase M1-1 Isoenzyme by Potęga, Agnieszka, Rafalska, Dominika, Kazimierczyk, Dawid, Kosno, Michał, Pawłowicz, Aleksandra, Andrałojć, Witold, Paluszkiewicz, Ewa, Laskowski, Tomasz

“…This work is the next step in studying the interplay between C-2028 (anticancer-active unsymmetrical bisacridine developed in our group) and the glutathione…”
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The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies by Laskowski, Tomasz, Kosno, Michał, Andrałojć, Witold, Frackowiak, Joanna E., Borzyszkowska-Bukowska, Julia, Szczeblewski, Paweł, Radoń, Nikola, Świerżewska, Maria, Woźny, Anna, Paluszkiewicz, Ewa, Mazerska, Zofia

“…Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic…”
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Acid–Base Equilibrium and Self-Association in Relation to High Antitumor Activity of Selected Unsymmetrical Bisacridines Established by Extensive Chemometric Analysis by Kosno, Michał, Laskowski, Tomasz, Frackowiak, Joanna E., Potęga, Agnieszka, Kurdyn, Agnieszka, Andrałojć, Witold, Borzyszkowska-Bukowska, Julia, Szwarc-Karabyka, Katarzyna, Mazerska, Zofia

“…Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents previously synthesized by our group. Our recent studies have demonstrated their…”
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The role of centrifugal partition chromatography in the removal of β-asarone from Acorus calamus essential oil by Szczeblewski, Paweł, Wróblewski, Mateusz, Borzyszkowska-Bukowska, Julia, Bairamova, Tetiana, Górska, Justyna, Laskowski, Tomasz, Samulewicz, Anna, Kosno, Michał, Sobiech, Łukasz, Polit, Justyna Teresa, Kukula-Koch, Wirginia

“…Β -asarone is a phenylpropane derivative present in the rhizomes of Acorus calamus , that was proved to exhibit toxic effects in humans. Because of its…”
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Distinct cellular uptake patterns of two anticancer unsymmetrical bisacridines and their metabolic transformation in tumor cells by Frackowiak, Joanna E., Kubica, Paweł, Kosno, Michał, Potęga, Agnieszka, Owczarek-Grzymkowska, Katarzyna, Borzyszkowska-Bukowska, Julia, Laskowski, Tomasz, Paluszkiewicz, Ewa, Mazerska, Zofia

“…Unsymmetrical bisacridines (UAs) represent a novel class of anticancer agents. Their high cytotoxicity towards multiple human cancer cell lines and inhibition…”
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Metabolic Profiles of New Unsymmetrical Bisacridine Antitumor Agents in Electrochemical and Enzymatic Noncellular Systems and in Tumor Cells by Mieszkowska, Anna, Nowicka, Anna M, Kowalczyk, Agata, Potęga, Agnieszka, Pawłowska, Monika, Kosno, Michał, Augustin, Ewa, Mazerska, Zofia

“…New unsymmetrical bisacridines (UAs) demonstrated high activity not only against a set of tumor cell lines but also against human tumor xenografts in nude…”
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QUALITY OF LIFE IN WOMEN AFTER MASTECTOMY. CLINICAL AND SOCIAL STUDY by Kuliński, Włodzisław, Kosno, Michał

“…The aim: To assess the quality of life in women after mastectomy. Materials and methods: The study included 25 women after mastectomy. The patients were aged…”
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Photochemical Rearrangement of a 19‐Membered Azoxybenzocrown: Products and their Properties by Wagner‐Wysiecka, Ewa, Szulc, Paulina, Luboch, Elżbieta, Chojnacki, Jarosław, Szwarc‐Karabyka, Katarzyna, Łukasik, Natalia, Murawski, Miłosz, Kosno, Michał

“…The preparation and characterization of products of the chemical and photochemical rearrangements of a 19‐membered o,o′‐azoxybenzocrown are presented. In…”
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