Search Results - "Kosmider, B"

Trolox contributes to Nrf2-mediated protection of human and murine primary alveolar type II cells from injury by cigarette smoke by Messier, E M, Bahmed, K, Tuder, R M, Chu, H W, Bowler, R P, Kosmider, B

“…Cigarette smoke (CS) is a main risk factor for chronic obstructive pulmonary disease (COPD). Oxidative stress induced by CS causes DNA and lung damage…”
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Comparison between the genotoxicity of cis-Pt(II) complex of 3-aminoflavone and cis-DDP in lymphocytes evaluated by the comet assay by KOSMIDER, B, OSIECKA, R, ZYNER, E, OCHOCKI, J

“…cis-bis(3-aminoflavone)dichloroplatinum(II) [cis-Pt(II) complex of 3-aminoflavone] is an analog of cis-DDP characterized by low cytotoxicity and anticancer…”
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Orally Active Trifluoromethyl Ketone Inhibitors of Human Leukocyte Elastase by Veale, Chris A, Bernstein, Peter R, Bohnert, Claudia M, Brown, Frederick J, Bryant, Craig, Damewood, James R, Earley, Roger, Feeney, Scott W, Edwards, Philip D, Gomes, Bruce, Hulsizer, James M, Kosmider, Ben J, Krell, Robert D, Moore, Gary, Salcedo, Theodora W, Shaw, Andrew, Silberstein, David S, Steelman, Gary B, Stein, Mark, Strimpler, Anne, Thomas, Roy M, Vacek, Edward P, Williams, Joseph C, Wolanin, Donald J, Woolson, Sheila

“…This paper describes the development a series of peptidyl trifluoromethyl ketone inhibitors of human leukocyte elastase which are found to have excellent…”
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B109 ALVEOLAR EPITHELIAL CELL PLASTICITY IN INJURY AND FIBROSIS: Alveolar Type Ii Cell Injury In Emphysema by Kosmider, B, Messier, E, Tuder, R, Bowler, R P, Bahmed, K, Mitchell, J, Mason, R J

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C71 YOU ARE WHAT YOU BREATHE: AIRWAY CELL BIOLOGY IN COPD: Mechanisms Of Alveolar Type Ii Cell Injury In Emphysema by Bahmed, K, Messier, E, Tuder, R, Mitchell, J, Chu, H W, Bowler, R P, Mason, R, Kosmider, B

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A73 BEYOND CIGARETTE SMOKE IN COPD: Dna Damage In Human Alveolar Type Ii Cells In Emphysema by Kosmider, B, Vlasenko, L, Boukhenouna, S, Tan, L, Marchetti, N, Bolla, S, Mandapati, C, Xander, N, Kelsen, S, Criner, G J, Bahmed, K

“…Results Our data indicates high oxidative stress in human ATII cells induced by cigarette smoke extract in vitro as measured by 4-HNE staining by…”
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B61 POTPOURRI OF INJ-OURRI: EPITHELIAL CELLS IN LUNG INJURY AND REPAIR: Cigarette Smoke Induced Epithelial Her2 Activation Is EGFR Dependent And Leads To Increases In Epithelial Permeability And Il-6 Production by Finigan, J H, Vasu, V T, Foster, D, Kosmider, B, Chu, H, Kern, J A

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Flavonoid compounds: a review of anticancer properties and interactions with cis-diamminedichloroplatinum(II) by Kosmider, Beata, Osiecka, Regina

“…Flavonoid compounds, especially quercetin and genistein, have antitumor activity. These compounds are cytotoxic to cancer cells but have no or insignificant…”
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Induction of apoptosis and necrosis in A549 cells by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP by Kosmider, Beata, Zyner, Elzbieta, Osiecka, Regina, Ochocki, Justyn

“…Non-small cell lung cancer (NSCLC) includes a group of tumors that respond poorly to drugs. cis-Diamminedichloroplatinum(II) ( cis-DDP) toxicity still remains…”
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A Common Polymorphism in Extracellular Superoxide Dismutase Affects Cardiopulmonary Disease Risk by Altering Protein Distribution by Hartney, John M, Stidham, Timothy, Goldstrohm, David A, Oberley-Deegan, Rebecca E, Weaver, Michael R, Valnickova-Hansen, Zuzana, Scavenius, Carsten, Benninger, Richard K.P, Leahy, Katelyn F, Johnson, Richard, Gally, Fabienne, Kosmider, Beata, Zimmermann, Angela K, Enghild, Jan J, Nozik-Grayck, Eva, Bowler, Russell P

“…BACKGROUND—The enzyme extracellular superoxide dismutase (EC-SOD; SOD3) is a major antioxidant defense in lung and vasculature. A nonsynonomous…”
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Nonpeptidic Inhibitors of Human Leukocyte Elastase. 6. Design of a Potent, Intratracheally Active, Pyridone-Based Trifluoromethyl Ketone by Bernstein, Peter R, Gomes, Bruce C, Kosmider, Benedict J, Vacek, Edward P, Williams, Joseph C

“…Further modification of the 3-amino substituent in a trifluoromethyl ketone-based series of 3-amino-6-phenylpyridin-2-ones that had been optimized for oral…”
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Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and x-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones by Veale, Chris A, Bernstein, Peter R, Bryant, Craig, Ceccarelli, Christopher, Damewood, James R. Jr, Earley, Roger, Feeney, Scott W, Gomes, Bruce, Kosmider, Ben J

“…The effects of changes in substitution in a series of 5-amino-2-pyrimidin-6-ones on both in vitro activity and oral activity in an acute hemorrhagic assay have…”
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The involvement of non-B DNA structures in gross chromosomal rearrangements by Bacolla, Albino, Wojciechowska, Marzena, Kosmider, Beata, Larson, Jacquelynn E., Wells, Robert D.

“…Non-B DNA conformations adopted by certain types of DNA sequences promote genetic instabilities, especially gross rearrangements including translocations. We…”
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Electrochemical genosensing of the interaction between the potential chemotherapeutic agent, cis-bis(3-aminoflavone)dichloroplatinum(II) and DNA in comparison with cis-DDP by Erdem, Arzum, Kosmider, Beata, Osiecka, Regina, Zyner, Elzbieta, Ochocki, Justyn, Ozsoz, Mehmet

“…The interaction of cis-diamminedichloroplatinum(II) ( cis-DDP) and the potential novel chemotherapeutic agent, cis-bis(3-aminoflavone)dichloroplatinum(II) (…”
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RG 12561 (dalvastatin): a novel synthetic inhibitor of HMG-CoA reductase and cholesterol-lowering agent by Amin, D, Gustafson, S K, Weinacht, J M, Cornell, S A, Neuenschwander, K, Kosmider, B, Scotese, A C, Regan, J R, Perrone, M H

“…RG 12561 (dalvastatin) is a prodrug which converts to its open hydroxyacid form in the body. The Na salt of RG 12561 (RG 12561-Na) is a potent inhibitor of…”
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Fragile X repeats are potent inducers of complex, multiple site rearrangements in flanking sequences in Escherichia coli by Kosmider, Beata, Wells, Robert D.

“…(CGG·CCG) n repeats induce the formation of complex, multiple site rearrangements and/or gross deletions in flanking DNA sequences in Escherichia coli…”
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Induction of apoptosis and necrosis in lymphocytes by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP by Kosmider, Beata, Osiecka, Regina, Ciesielska, Ewa, Szmigiero, Leszek, Zyner, Elzbieta, Ochocki, Justyn

“…cis-Diamminedichloroplatinum(II) ( cis-DDP) is one of the most widely administrated antitumor drugs. However, the use of cis-DDP is severely limited because of…”
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Evaluation of the genotoxicity of cis-bis(3-aminoflavone)dichloroplatinum(II) in comparison with cis-DDP by Kosmider, Beata, Wyszynska, Kalina, Janik-Spiechowicz, Ewa, Osiecka, Regina, Zyner, Elzbieta, Ochocki, Justyn, Ciesielska, Ewa, Wasowicz, Wojciech

“…Short-term tests that detect genetic damage have provided information needed for evaluating carcinogenic risks of chemicals to man. The mutagenicity of…”
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Enhanced P53 and BAX gene expression and apoptosis in A549 cells by cis-Pt(II) complex of 3-aminoflavone in comparison with cis-DDP by Kosmider, Beata, Wojcik, Izabela, Osiecka, Regina, Bartkowiak, Jacek, Zyner, Elzbieta, Ochocki, Justyn, Liberski, Pawel

“…Lung cancer remains one of the most common causes of cancer-related death worldwide. Approximately 80% is histologically non-small cell lung carcinoma (NSCLC)…”
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Evaluation of P53 and BAX gene expression and induction of apoptosis and necrosis by the cis-Pt(II) complex of 3-aminoflavone in comparison with cis-diamminedichloroplatinum(II) ( cis-DDP) in human lymphocytes by Kosmider, Beata, Zawlik, Izabela, Liberski, Pawel P., Osiecka, Regina, Zyner, Elzbieta, Ochocki, Justyn, Bartkowiak, Jacek

“…Currently cis-diamminedichloroplatinum(II) ( cis-DDP) is one of the most commonly applied compounds in chemotherapy of many types of cancer. However, a…”
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