Search Results - "Koskinen, Anna"

Leptin – A Link between Obesity and Osteoarthritis. Applications for Prevention and Treatment by Vuolteenaho, Katriina, Koskinen, Anna, Moilanen, Eeva

“…Osteoarthritis (OA) is the most common cause of musculoskeletal disability and pain in the world. The current drug treatment for OA is symptom relieving, and…”
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Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage-Mediator Role of NO in Leptin-Induced PGE_2, IL-6, and IL-8 Production by Vuolteenaho, Katriina, Koskinen, Anna, Kukkonen, Meiju, Nieminen, Riina, Päivärinta, Unto, Moilanen, Teemu, Moilanen, Eeva

“…Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor…”
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YKL-40 as a Novel Factor Associated with Inflammation and Catabolic Mechanisms in Osteoarthritic Joints by Vuolteenaho, Katriina, Moilanen, Teemu, Hämäläinen, Mari, Paukkeri, Erja-Leena, Koskinen, Anna, Väänänen, Tuija, Moilanen, Eeva

“…YKL-40 is associated with tissue injury and inflammation, and consequently to diseases in which these mechanisms lead to tissue degradation, for example,…”
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Physical Stability of Freeze-Dried Isomalt Diastereomer Mixtures by Koskinen, Anna-Kaisa, Fraser-Miller, Sara J., Bøtker, Johan P., Heljo, Ville P., Barnsley, Jonathan E., Gordon, Keith C., Strachan, Clare J., Juppo, Anne M.

“…ABSTRACT Purpose Isomalt is a sugar alcohol used as an excipient in commercially available solid oral dosage forms. The potential of isomalt as a novel…”
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Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3 by Koskinen-Kolasa, Anna, Vuolteenaho, Katriina, Korhonen, Riku, Moilanen, Teemu, Moilanen, Eeva

“…Previous studies provide evidence that adipokine leptin increases production of catabolic and proinflammatory factors in chondrocytes and serves as a link…”
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Leptin Enhances Synthesis of Proinflammatory Mediators in Human Osteoarthritic Cartilage—Mediator Role of NO in Leptin-Induced PGE2, IL-6, and IL-8 Production by Vuolteenaho, Katriina, Koskinen, Anna, Kukkonen, Meiju, Nieminen, Riina, Päivärinta, Unto, Moilanen, Teemu, Moilanen, Eeva

“…Obesity is an important risk factor for osteoarthritis (OA) in weight-bearing joints, but also in hand joints, pointing to an obesity-related metabolic factor…”
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Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways by Koskinen, Anna, Juslin, Sami, Nieminen, Riina, Moilanen, Teemu, Vuolteenaho, Katriina, Moilanen, Eeva

“…Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and…”
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Leptin levels are increased and its negative regulators, SOCS-3 and sOb-R are decreased in obese patients with osteoarthritis: a link between obesity and osteoarthritis by Vuolteenaho, Katriina, Koskinen, Anna, Moilanen, Teemu, Moilanen, Eeva

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Congruence between nursing students’ and patients’ views of student–patient relationships by Suikkala, Arja, Koskinen, Sanna, Katajisto, Jouko, Leino-Kilpi, Helena

“…The growing emphasis on learning with and from patients has shifted the focus from education and healthcare professionals to the student–patient relationship…”
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Adipokines as drug targets in joint and bone disease by Scotece, Morena, Conde, Javier, Vuolteenaho, Katriina, Koskinen, Anna, López, Veronica, Gómez-Reino, Juan, Lago, Francisca, Moilanen, Eeva, Gualillo, Oreste

“…•Adipose tissue is a major driver of inflammation in bone and cartilage disease.•Adipokines are also produced by chondrocytes, synoviocytes and immune…”
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Leptin enhances MMP-1, MMP-3 and MMP-13 production in human osteoarthritic cartilage and correlates with MMP-1 and MMP-3 in synovial fluid from OA patients by KOSKINEN, A, VUOLTEENAHO, K, NIEMINEN, R, MOILANEN, T, MOLLANEN, E

“…In the present study, we investigated the role of adipocytokine leptin in the pathogenesis of osteoarthritis (OA) by measuring its effects on matrix…”
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Gestational hyperglycemia reprograms cardiac gene expression in rat offspring by Lehtoranta, Lara, Koskinen, Anna, Vuolteenaho, Olli, Laine, Jukka, Kytö, Ville, Soukka, Hanna, Ekholm, Eeva, Räsänen, Juha

“…Background Rat fetuses with maternal pregestational hyperglycemia develop cardiac dysfunction, and their cardiac gene expression differs from that of healthy…”
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Intracerebroventricular Oxytocin Effects on mRNA Abundance Differ in Adipose Tissue of Chicks from Low and High Body Weight‐Selected Lines by Koskinen, Anna, McConn, Betty, Wang, Guoqing, Siegel, Paul B, Cline, Mark A, Gilbert, Elizabeth R

“…Abstract only Neuropeptide oxytocin (OXT), an important anorexigenic factor in the central nervous system, has been shown to have effects on adipose tissue…”
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Central injection of oxytocin reduces food intake and affects hypothalamic and adipose tissue gene expression in chickens by McConn, Betty R., Koskinen, Anna, Denbow, D. Michael, Gilbert, Elizabeth R., Siegel, Paul B., Cline, Mark A.

“…Oxytocin (OT) is a well-characterized neurotransmitter that participates in a wide range of physiological processes including the inhibition of food intake…”
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Maternal hyperglycemia leads to fetal cardiac hyperplasia and dysfunction in a rat model by Lehtoranta, Lara, Vuolteenaho, Olli, Laine, V Jukka, Koskinen, Anna, Soukka, Hanna, Kytö, Ville, Määttä, Jorma, Haapsamo, Mervi, Ekholm, Eeva, Räsänen, Juha

“…Accelerated fetal myocardial growth with altered cardiac function is a well-documented complication of human diabetic pregnancy, but its pathophysiology is…”
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Delay in rat lung alveolarization after the combined exposure of maternal hyperglycemia and postnatal hyperoxia by Koskinen, Anna, Lukkarinen, Heikki, Laine, Jukka, Ahotupa, Markku, Kääpä, Pekka, Soukka, Hanna

“…Summary Background Maternal diabetes interferes with fetal lung development and postnatal treatments may further disturb pulmonary growth. Therefore, we…”
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Delay in rat lung alveolarization after the combined exposure of maternal hyperglycemia and postnatal hyperoxia: hyperglycemia-hyperoxia in neonatal lung by Koskinen, Anna, Lukkarinen, Heikki, Laine, Jukka, Ahotupa, Markku, Kääpä, Pekka, Soukka, Hanna

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Fetal hyperglycemia alters lung structural development in neonatal rat by Koskinen, Anna, Lukkarinen, Heikki, Moritz, Niko, Aho, Heikki, Kääpä, Pekka, Soukka, Hanna

“…Maternal diabetes is associated with increased risk for abnormal fetal organogenesis, but its effects on the developing lungs are still insufficiently known…”
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Maternal hyperglycemia modifies extracellular matrix signaling pathways in neonatal rat lung by Koskinen, Anna, Laiho, Asta, Lukkarinen, Heikki, Kääpä, Pekka, Soukka, Hanna

“…Maternal diabetes is associated with numerous adverse effects in fetal and neonatal organs, including the lungs. To investigate the effects of intrauterine…”
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Novel adipokine associated with OA: retinol binding protein 4 (RBP4) is produced by cartilage and is correlated with MMPs in osteoarthritis patients by Scotece, Morena, Koskinen-Kolasa, Anna, Pemmari, Antti, Leppänen, Tiina, Hämäläinen, Mari, Moilanen, Teemu, Moilanen, Eeva, Vuolteenaho, Katriina

“…Objective Retinol binding protein 4 (RBP4) is a member of the lipocalin family and a vitamin A carrier in the blood. More recently, RBP4 has been described as…”
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