Diminished salivary epidermal growth factor secretion: a link between Sjögren's syndrome and autoimmune gastritis?

Objectives: Healthy human labial salivary glands produce epidermal growth factor (EGF). In Sjögren's syndrome (SS), EGF staining is diminished. SS is also associated with chronic autoimmune corpus gastritis. We therefore hypothesized that EGF secretion would be diminished in SS and that this co...

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Bibliographic Details
Published in:	Scandinavian journal of rheumatology Vol. 45; no. 2; pp. 118 - 121
Main Authors:	Koskenpato, K, Ainola, M, Przybyla, B, Kouri, V-P, Virkki, L, Koskenpato, J, Ristimäki, A, Konttinen, YT
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 03-03-2016
Subjects:	Adult Aged Autoimmune Diseases - metabolism Case-Control Studies Chief Cells, Gastric - metabolism Enzyme-Linked Immunosorbent Assay Epidermal Growth Factor - secretion Female Gastritis - metabolism Humans Immunohistochemistry Middle Aged Parietal Cells, Gastric - metabolism Receptor, Epidermal Growth Factor - metabolism Saliva - chemistry Sjogren's Syndrome - metabolism Stomach - metabolism Young Adult
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Summary:	Objectives: Healthy human labial salivary glands produce epidermal growth factor (EGF). In Sjögren's syndrome (SS), EGF staining is diminished. SS is also associated with chronic autoimmune corpus gastritis. We therefore hypothesized that EGF secretion would be diminished in SS and that this could affect gastric target cells. Methods: Salivary EGF secretion in SS was compared to that in healthy controls using an enzyme-linked immunosorbent assay (ELISA). EGF receptor (EGFR) immunoreactive cells in the gastric corpus of healthy human subjects were analysed using immunostaining. Results: Salivary secretion of EGF was diminished in SS patients (232.4, range 52.6-618.4, vs. 756.6, range 105.3-1631.6 pg/min, p = 0.002). Proton-pump positive parietal cells were mostly EGFR immunoreactive whereas very few pepsinogen I (PGI)-positive cells were EGFR positive. Conclusions: As EGF is relatively acid resistant, salivary gland-derived EGF might participate in an exo/endocrine mode of parietal cell maintenance in the gastric corpus. Deficiency of salivary gland-derived EGF in SS patients may cause impairment of gastric parietal cells resulting in exposure of immunogenic cryptic antigens and loss of immunological self-tolerance.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0300-9742 1502-7732
DOI:	10.3109/03009742.2015.1072243