Search Results - "Koskela, Sirpa"

Ex vivo venetoclax sensitivity testing predicts treatment response in acute myeloid leukemia by Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Ranta, Amanda, Huuhtanen, Jani, Suvela, Minna, Parsons, Alun, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E L, Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Västrik, Imre, Dufva, Olli, Siitonen, Sanna, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A, Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

“…The BCL-2 inhibitor venetoclax has revolutionized the treatment of acute myeloid leukemia (AML) in patients not benefiting from intensive chemotherapy…”
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Coagulopathy in Acute Puumala Hantavirus Infection by Koskela, Sirpa, Mäkelä, Satu, Strandin, Tomas, Vaheri, Antti, Outinen, Tuula, Joutsi-Korhonen, Lotta, Pörsti, Ilkka, Mustonen, Jukka, Laine, Outi

“…Puumala hantavirus (PUUV) causes a hemorrhagic fever with renal syndrome (HFRS), also called nephropathia epidemica (NE), which is mainly endemic in Europe and…”
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Endothelial Nitric Oxide Synthase G894T Polymorphism Associates with Disease Severity in Puumala Hantavirus Infection by Koskela, Sirpa, Laine, Outi, Mäkelä, Satu, Pessi, Tanja, Tuomisto, Sari, Huhtala, Heini, Karhunen, Pekka J, Pörsti, Ilkka, Mustonen, Jukka

“…Hantavirus infections are characterized by both activation and dysfunction of the endothelial cells. The underlying mechanisms of the disease pathogenesis are…”
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Diminished coagulation capacity assessed by calibrated automated thrombography during acute Puumala hantavirus infection by Koskela, Sirpa M, Joutsi-Korhonen, Lotta, Mäkelä, Satu M, Huhtala, Heini, Vaheri, Antti I, Pörsti, Ilkka, Mustonen, Jukka T, Laine, Outi K

“…Coagulation abnormalities are associated with Puumala-virus-induced hemorrhagic fever with renal syndrome (PUUV–HFRS). We evaluated the coagulation capacity of…”
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P562: CAPILLARY BLOOD SAMPLING ALLOWS FEASIBLE METHOD FOR VENETOCLAX CONCENTRATION MEASUREMENT IN AN ACADEMIC MULTICENTER CLINICAL TRIAL CONTEXT by Kytölä, Sari, Vänttinen, Ida, Kuusanmäki, Heikki, Ruokoranta, Tanja, Kurkela, Mika, Kiiski, Johanna, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä‐Remes, Maija, Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, T. Backman, Janne, Niemi, Mikko, Kontro, Mika

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Plasma pentraxin-3 and coagulation and fibrinolysis variables during acute Puumala hantavirus infection and associated thrombocytopenia by Laine, Outi K, Koskela, Sirpa M, Outinen, Tuula K, Joutsi-Korhonen, Lotta, Huhtala, Heini, Vaheri, Antti, Hurme, Mikko A, Jylhävä, Juulia, Mäkelä, Satu M, Mustonen, Jukka T

“…Thrombocytopenia and altered coagulation characterize all hantavirus infections. To further assess the newly discovered predictive biomarkers of disease…”
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Ex Vivo Venetoclax Sensitivity Predicts Clinical Response in Acute Myeloid Leukemia in the Prospective VenEx Trial by Kytölä, Sari, Vänttinen, Ida Maria, Ruokoranta, Tanja, Partanen, Anu, Holopainen, Annasofia, Saad, Joseph, Kuusisto, Milla E L, Koskela, Sirpa, Räty, Riikka Katariina, Itälä-Remes, Maija, Västrik, Imre, Suvela, Minna, Parsons, Alun Owen, Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A, Jalkanen, Tero, Huttunen, Teppo, Ettala, MD, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, Kuusanmäki, Heikki, Kontro, Mika

“…The BCL2 inhibitor venetoclax has shown promise for treating acute myeloid leukemia (AML). However, identifying patients likely to respond remains a challenge,…”
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Ex Vivo Drug Sensitivity Testing to Predict Response to Venetoclax + Azacitidine in Acute Myeloid Leukemia: Interim Results of the Prospective Multicenter Phase II Venex Trial by Kuusanmäki, Heikki, Kytölä, Sari, Vänttinen, Ida, Ranta, Amanda, Ruokoranta, Tanja, Holopainen, Annasofia, Koskela, Sirpa, Kuusisto, Milla E.L., Porkka, Kimmo, Räty, Riikka, Västrik, Imre, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Pyörälä, Marja, Rimpiläinen, Johanna, Siitonen, Timo, Kontro, Mika

“…Background BCL-2 inhibitor venetoclax (Ven) in combination with azacitidine (Aza) has substantially improved overall response rates (ORR) and overall survival…”
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Ex Vivo Venetoclax Sensitivity Testing Predicts Response and Overall Survival in De Novo and s/R/R AML Patients Treated with Azacitidine and Venetoclax by Kytölä, Sari, Vänttinen, Ida, Ruokoranta, Tanja, Holopainen, Annasofia, Partanen, Anu, Kuusisto, Milla E.L., Koskela, Sirpa, Räty, Riikka, Itälä-Remes, Maija, Ranta, Amanda, Suvela, Minna, Parsons, Alun, Västrik, Imre, Siitonen, Sanna M., Porkka, Kimmo, Wennerberg, Krister, Heckman, Caroline A., Ettala, Pia, Rimpiläinen, Johanna, Siitonen, Timo, Pyörälä, Marja, Kuusanmäki, Heikki, Kontro, Mika

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Spleen enlargement is a common finding in acute Puumala hantavirus infection and it does not associate with thrombocytopenia by Koskela, Sirpa M., Laine, Outi K., Paakkala, Antti S., Mäkelä, Satu M., Mustonen, Jukka T.

“…Abstract The pathogenesis of thrombocytopenia in Puumala hantavirus (PUUV) infection is probably multifactorial. We aimed to evaluate the possible spleen…”
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Severe Puumala virus infection in a patient with a lymphoproliferative disease treated with icatibant by Laine, Outi, Leppänen, Ilona, Koskela, Sirpa, Antonen, Jaakko, Mäkelä, Satu, Sinisalo, Marjatta, Vaheri, Antti, Mustonen, Jukka

“…Abstract Early identification of patients at risk of a severe course of hantaviral disease and lack of effective medication represent a global challenge in the…”
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Endothelial Nitric Oxide Synthase G894T Polymorphism Associates with Disease Severity in Puumala Hantavirus Infection: e0142872 by Koskela, Sirpa, Laine, Outi, Maekelae, Satu, Pessi, Tanja, Tuomisto, Sari, Huhtala, Heini, Karhunen, Pekka J, Porsti, Ilkka, Mustonen, Jukka

“…Introduction Hantavirus infections are characterized by both activation and dysfunction of the endothelial cells. The underlying mechanisms of the disease…”
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Severe Puumala virus infection in a patient with a lymphoproliferative disease treated with icatibant by Laine, Outi, Leppänen, Ilona, Koskela, Sirpa, Antonen, Jaakko, Mäkelä, Satu, Sinisalo, Marjatta, Vaheri, Antti, Mustonen, Jukka

“…Early identification of patients at risk of a severe course of hantaviral disease and lack of effective medication represent a global challenge in the…”
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