Search Results - "Kosinska, Anna"

Intramolecular recombination enables the formation of hepatitis B virus (HBV) cccDNA in mice after HBV genome transfer using recombinant AAV vectors by Ko, Chunkyu, Su, Jinpeng, Festag, Julia, Bester, Romina, Kosinska, Anna D., Protzer, Ulrike

“…The mouse is not a natural host of hepatitis B virus (HBV) infection and - despite engraftment of hepatocytes with the HBV receptor - does not support…”
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Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice by Michler, Thomas, Kosinska, Anna D., Festag, Julia, Bunse, Till, Su, Jinpeng, Ringelhan, Marc, Imhof, Hortenzia, Grimm, Dirk, Steiger, Katja, Mogler, Carolin, Heikenwalder, Mathias, Michel, Marie-Louise, Guzman, Carlos A., Milstein, Stuart, Sepp-Lorenzino, Laura, Knolle, Percy, Protzer, Ulrike

“…Hepatitis B virus (HBV) infection persists because the virus-specific immune response is dysfunctional. Therapeutic vaccines might be used to end immune…”
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Therapeutic vaccination for chronic hepatitis B by Kosinska, Anna D., Bauer, Tanja, Protzer, Ulrike

“…•Prophylactic vaccines work well, but we still lack a successful therapeutic vaccine able to break immune tolerance in chronic infection or cancer.•Chronic…”
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Exploring the use of nanofluids in pump-free systems for solar thermal applications by Kosinska, Anna, Balakin, Boris V., Kosinski, Pawel

“…By using nanofluids as a working fluid in pump-free designs, thermal energy systems can become more efficient and have reduced maintenance costs, ultimately…”
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Combination of DNA prime--adenovirus boost immunization with entecavir elicits sustained control of chronic hepatitis B in the woodchuck model by Kosinska, Anna D, Zhang, Ejuan, Johrden, Lena, Liu, Jia, Seiz, Pia L, Zhang, Xiaoyong, Ma, Zhiyong, Kemper, Thekla, Fiedler, Melanie, Glebe, Dieter, Wildner, Oliver, Dittmer, Ulf, Lu, Mengji, Roggendorf, Michael

“…A potent therapeutic T-cell vaccine may be an alternative treatment of chronic hepatitis B virus (HBV) infection. Previously, we developed a DNA…”
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Polarization of Monocytic Myeloid-Derived Suppressor Cells by Hepatitis B Surface Antigen Is Mediated via ERK/IL-6/STAT3 Signaling Feedback and Restrains the Activation of T Cells in Chronic Hepatitis B Virus Infection by Fang, Zhong, Li, Jin, Yu, Xiaoyu, Zhang, Dandan, Ren, Guangxu, Shi, Bisheng, Wang, Cong, Kosinska, Anna D, Wang, Sen, Zhou, Xiaohui, Kozlowski, Maya, Hu, Yunwen, Yuan, Zhenghong

“…Chronic hepatitis B virus (HBV) infection is characterized by T cell tolerance to virus. Although inhibition of T cell responses by myeloid-derived suppressor…”
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Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection by Liu, Jia, Zhang, Ejuan, Ma, Zhiyong, Wu, Weimin, Kosinska, Anna, Zhang, Xiaoyong, Möller, Inga, Seiz, Pia, Glebe, Dieter, Wang, Baoju, Yang, Dongliang, Lu, Mengji, Roggendorf, Michael

“…Hepatitis B virus (HBV) persistence is facilitated by exhaustion of CD8 T cells that express the inhibitory receptor programmed cell death-1 (PD-1)…”
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Photothermal conversion of biodegradable fluids and carbon black nanofluids by Kosinska, Anna, Balakin, Boris V., Kosinski, Pawel

“…The paper is devoted to the topic of direct absorption solar collectors (DASCs). Various kinds of fluids can be used as heat transfer fluid in DASCs, and the…”
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Depletion of T cells via Inducible Caspase 9 Increases Safety of Adoptive T-Cell Therapy Against Chronic Hepatitis B by Klopp, Alexandre, Schreiber, Sophia, Kosinska, Anna D, Pulé, Martin, Protzer, Ulrike, Wisskirchen, Karin

“…T-cell therapy with T cells that are re-directed to hepatitis B virus (HBV)-infected cells by virus-specific receptors is a promising therapeutic approach for…”
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Editorial: Targeting the Immune System to Treat Hepatitis B Virus Infection by Meng, Zhongji, Liu, Jia, Kosinska, Anna D, Lu, Mengji

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Activation of CD4 T cells during prime immunization determines the success of a therapeutic hepatitis B vaccine in HBV-carrier mouse models by Su, Jinpeng, Brunner, Livia, Ates Oz, Edanur, Sacherl, Julia, Frank, Geraldine, Kerth, Helene Anne, Thiele, Frank, Wiegand, Marian, Mogler, Carolin, Aguilar, Julio Cesar, Knolle, Percy A., Collin, Nicolas, Kosinska, Anna D., Protzer, Ulrike

“…We recently developed a heterologous therapeutic vaccination scheme (TherVacB) comprising a particulate protein prime followed by a modified vaccinia-virus…”
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Current status of immunomodulatory therapy in chronic hepatitis B, fifty years after discovery of the virus: Search for the “magic bullet” to kill cccDNA by Zhang, Ejuan, Kosinska, Anna, Lu, Mengji, Yan, Huimin, Roggendorf, Michael

“…•The difficulty of therapy in chronic HBV infection is due to the existence of mini-chromosomes of cccDNA.•HBV-specific T and B cell responses are crucial in…”
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Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection by Kosinska, Anna D., Moeed, Abdul, Kallin, Nina, Festag, Julia, Su, Jinpeng, Steiger, Katja, Michel, Marie-Louise, Protzer, Ulrike, Knolle, Percy A.

“…Therapeutic vaccination against chronic hepatitis B must overcome high viral antigen load and local regulatory mechanisms that promote immune-tolerance in the…”
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PD-L1 Silencing in Liver Using siRNAs Enhances Efficacy of Therapeutic Vaccination for Chronic Hepatitis B by Bunse, Till, Kosinska, Anna D, Michler, Thomas, Protzer, Ulrike

“…In chronic hepatitis B virus (HBV) infection, virus-specific T cells are scarce and partially dysfunctional. Therapeutic vaccination is a promising strategy to…”
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Low hepatitis B virus–specific T‐cell response in males correlates with high regulatory T‐cell numbers in murine models by Kosinska, Anna D., Pishraft‐Sabet, Leila, Wu, Weimin, Fang, Zhong, Lenart, Marzena, Chen, Jieliang, Dietze, Kirsten K., Wang, Cong, Kemper, Thekla, Lin, Yong, Yeh, Shiou‐Hwei, Liu, Jia, Dittmer, Ulf, Yuan, Zhenghong, Roggendorf, Michael, Lu, Mengji

“…Hepatitis B virus (HBV) infection shows significant gender‐related differences in pathogenesis, disease progression, and development of hepatocellular…”
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CARs derived from broadly neutralizing, human monoclonal antibodies identified by single B cell sorting target hepatitis B virus-positive cells by Schreiber, Sophia, Dressler, Lisa S, Loffredo-Verde, Eva, Asen, Theresa, Färber, Stephanie, Wang, Wenshi, Groll, Tanja, Chakraborty, Anindita, Kolbe, Fenna, Kreer, Christoph, Kosinska, Anna D, Simon, Sylvain, Urban, Stephan, Klein, Florian, Riddell, Stanley R, Protzer, Ulrike

“…To design new CARs targeting hepatitis B virus (HBV), we isolated human monoclonal antibodies recognizing the HBV envelope proteins from single B cells of a…”
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Production and Purification of Adeno-Associated Viral Vectors for the Development of Immune-Competent Mouse Models of Persistent Hepatitis B Virus Replication by Schiller, Lisa, Ko, Chunkyu, Kosinska, Anna D, Grimm, Dirk, Protzer, Ulrike

“…Mice infected with a recombinant adeno-associated virus carrying a replication-competent hepatitis B virus genome (rAAV-HBV) via the intravenous route…”
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The Woodchuck, a Nonprimate Model for Immunopathogenesis and Therapeutic Immunomodulation in Chronic Hepatitis B Virus Infection by Roggendorf, Michael, Kosinska, Anna D, Liu, Jia, Lu, Mengji

“…The woodchuck hepatitis virus (WHV) and its host, the eastern woodchuck, is a very valuable model system for hepatitis B virus infection. Many aspects of WHV…”
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Experimental study of a direct absorption solar collector with stationary nanofluid by Eriksen, Agathe Bjelland, Kosinski, Pawel, Balakin, Boris V., Kosinska, Anna

“…•Experiments on carbon black nanofluids in a direct absorption solar collector were conducted.•The setup used stationary nanofluids for solar absorption, which…”
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A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection by Bosch, Miriam, Kallin, Nina, Donakonda, Sainitin, Zhang, Jitao David, Wintersteller, Hannah, Hegenbarth, Silke, Heim, Kathrin, Ramirez, Carlos, Fürst, Anna, Lattouf, Elias Isaac, Feuerherd, Martin, Chattopadhyay, Sutirtha, Kumpesa, Nadine, Griesser, Vera, Hoflack, Jean-Christophe, Siebourg-Polster, Juliane, Mogler, Carolin, Swadling, Leo, Pallett, Laura J., Meiser, Philippa, Manske, Katrin, de Almeida, Gustavo P., Kosinska, Anna D., Sandu, Ioana, Schneider, Annika, Steinbacher, Vincent, Teng, Yan, Schnabel, Julia, Theis, Fabian, Gehring, Adam J., Boonstra, Andre, Janssen, Harry L. A., Vandenbosch, Michiel, Cuypers, Eva, Öllinger, Rupert, Engleitner, Thomas, Rad, Roland, Steiger, Katja, Oxenius, Annette, Lo, Wan-Lin, Klepsch, Victoria, Baier, Gottfried, Holzmann, Bernhard, Maini, Mala K., Heeren, Ron, Murray, Peter J., Thimme, Robert, Herrmann, Carl, Protzer, Ulrike, Böttcher, Jan P., Zehn, Dietmar, Wohlleber, Dirk, Lauer, Georg M., Hofmann, Maike, Luangsay, Souphalone, Knolle, Percy A.

“…Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide 1 , 2 , in whom virus-specific CD8 T cells by still ill-defined mechanisms…”
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