Search Results - "Koshland, Marian Elliott"

Dependence of BSAP Repressor and Activator Functions on BSAP Concentration by Wallin, Jeffrey J., Gackstetter, Edwin R., Koshland, Marian Elliott

“…During a B cell immune response, the transcription factor BSAP maintains its activator functions but is relieved of its repressor functions. This selective…”
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B Cell-specific Activator Protein Prevents Two Activator Factors from Binding to the Immunoglobulin J Chain Promoter until the Antigen-driven Stages of B Cell Development by Wallin, J J, Rinkenberger, J L, Rao, S, Gackstetter, E R, Koshland, M E, Zwollo, P

“…The immunoglobulin J chain gene is inducibly transcribed in mature B cells upon antigen recognition and a signal from interleukin-2 (IL-2). B cell-specific…”
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Mechanism of Interleukin-2 Signaling: Mediation of Different Outcomes by a Single Receptor and Transduction Pathway by Tigges, Michael A., Casey, Leslie S., Koshland, Marian Elliott

“…The T cell lymphokine, interleukin-2 (Il-2), plays a pivotal role in an immune response by stimulating antigen-activated B lymphocytes to progress through the…”
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Interleukin 2- and Interleukin 5-Induced Changes in the Binding of Regulatory Factors to the J-Chain Gene Promoter by MCFADDEN, H. J, KOSHLAND, M. E

“…In a primary immune response, B cells require signals from the T-cell lymphokines interleukins 2 and 5 (IL-2 and IL-5) to develop into IgM-secreting cells. One…”
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Mechanism of IgM Polymerization by Chapuis, Rose Marie, Koshland, Marian Elliott

“…The stoichiometry of J chain in pentamer IgM has been determined by measuring the radiolabeled thiols in the constituent chains after complete reduction and…”
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Characterization of the J Chain from Polymeric Immunoglobulins by Morrison, Sherie L., Koshland, Marian Elliott

“…The J chains isolated from polymeric IgA and IgM were shown to be distinct from the other immunoglobulin subunits, including the secretory component, both on…”
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Ets-related protein PU.1 regulates expression of the immunoglobulin J-chain gene through a novel ets-binding element by SHIN, M. K, KOSHLAND, M. E

“…In a primary immune response, a signal from interleukin-2 (IL-2) activates transcription of the gene encoding the pentamer IgM joining component, the J chain…”
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The Stoichiometry of J Chain in Human Secretory IgA by Halpern, Michael S, Koshland, Marian Elliott

“…Abstract Quantitative methods were developed to measure the J chain content of the polymeric immunoglobulins. The methods involved two steps: first, isolation…”
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Dependence of BSAP repressor and activator functions on BSAP concentrations by Wallin, Jeffrey J, Koshland, Marian Elliott

“…During a B cell immune response, the transcription factor BSAP maintains its activator functions but is relieved of its repressor functions. This selective…”
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A Stage-Specific Enhancer of Immunoglobulin J Chain Gene Is Induced by Interleukin-2 in a Presecretor B Cell Stage by Kang, Chang-Joong, Sheridan, Colleen, Koshland, Marian Elliott

“…Interleukin-2 (IL-2)–induced transcription of the J chain gene was used as a model for analyzing cytokine regulation during B cell development. To determine…”
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Polymer IgM Assembly and Secretion in Lymphoid and Nonlymphoid Cell Lines: Evidence that J Chain is Required for Pentamer IgM Synthesis by Niles, Mary Jane, Matsuuchi, Linda, Koshland, Marian Elliott

“…The requirements for IgM assembly and secretion were evaluated by introducing a constitutively expressed J-chain cDNA into lymphoid and nonlymphoid cell lines…”
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Evidence for Multiple Gene Control of a Single Polypeptide Chain: The Heavy Chain of Rabbit Immunoglobulin by Koshland, Marian Elliott, Davis, Judith J., Fujita, N. Joan

“…To determine the chemical basis for rabbit heavy chain allotypes, amino acid analyses were carried out on IgG and IgM antibodies isolated from rabbits which…”
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Glycosylphosphatidylinositol: A Candidate System for Interleukin-2 Signal Transduction by Eardley, Diane D., Koshland, Marian Elliott

“…The mechanism of interleukin-2 (IL-2) signal transduction was analyzed by use of an inducible B lymphoma. Like normal antigen-activated B lymphocytes, the…”
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B Cell-specific Activator Protein Prevents Two Activator Factors from Binding to the Immunoglobulin J ChainPromoter until the Antigen-driven Stages of B Cell Development by Wallin, Jeffrey J., Rinkenberger, Julie L., Rao, Sulekha, Gackstetter, Edwin R., Koshland, Marian Elliott, Zwollo, Patty

“…The immunoglobulin J chain gene is inducibly transcribed in mature B cells upon antigen recognition and a signal from interleukin-2 (IL-2). B cell-specific…”
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The Coming of Age of the Immunoglobulin J Chain by Koshland, M E

“…During the last decade the immunoglobulin J chain has indeed come of age. The amino-acid sequence has been determined for the mouse and human polypeptides, and…”
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An Interleukin-2 Signal Relieves BSAP (Pax5)-Mediated Repression of the Immunoglobulin J Chain Gene by Rinkenberger, Julie L, Wallin, Jeffrey J, Johnson, Kirk W, Koshland, Marian Elliott

“…Cytokine regulation of B cell development was analyzed using interleukin-2 (IL-2)-induced transcription of the J chain gene as a model system. A nuclear target…”
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Dynamic chromatin remodeling in the vicinity of J chain gene for the regulation of two stage-specific genes during B cell differentiation by Kang, C J, Oh, U, Koshland, M E

“…Dynamic chromatin remodeling during B cell differentiation was identified in the vicinity of J chain gene. In pre-B cells, the enhancer-containing DNase I…”
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Sheer Luck Made Me An Immunologist by Koshland, Marian Elliott

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Changes in J chain and μ chain RNA expression as a function of B cell differentiation by LAMSON, G, KOSHLAND, M. E

“…The time course of differentiative events in the pentamer IgM response was examined by following the expression of J chain and mu chain RNA and their protein…”
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A model system for peptide hormone action in differentiation: interleukin 2 induces a B lymphoma to transcribe the J chain gene by Blackman, M A, Tigges, M A, Minie, M E, Koshland, M E

“…Physiological levels of a purified T cell hormone, interleukin 2 (IL-2), were found to stimulate a cloned murine B cell line (BCL1) to secrete pentamer IgM…”
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