Rotavirus vaccine strain transmission by vaccinated infants in the foster home

Rotavirus vaccine strain transmission by vaccinated infants in the foster home

Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought to fully elucidate the safety of rotavirus (RV) vaccination in closed contact circumstance, such as the foster home for future assessment of the vaccine safe...

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Bibliographic Details
Published in:Journal of medical virology Vol. 89; no. 1; pp. 79 - 84
Main Authors: Miura, Hiroki, Kawamura, Yoshiki, Sugata, Ken, Koshiyama, Nozomi, Yoshikawa, Akiko, Komoto, Satoshi, Taniguchi, Koki, Ihira, Masaru, Yoshikawa, Tetsushi
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-01-2017
Subjects:
Babies
Cross Infection - transmission
Cross Infection - virology
Disease transmission
Feces - virology
Female
Foster care
horizontal transmission
human rotavirus
Humans
Immunization
Infant
Male
Prospective Studies
Real-Time Polymerase Chain Reaction
Reoviridae
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral - analysis
Rotavirus - classification
Rotavirus - isolation & purification
Rotavirus Infections - transmission
Rotavirus Infections - virology
Rotavirus Vaccines - administration & dosage
Time Factors
vaccine
Vaccines
viral excretion
Viral Load
Virology
Viruses
human rotavirus
viral excretion
vaccine
horizontal transmission
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Summary:Previous studies have demonstrated the transmission of rotavirus vaccine strains from vaccinated children to nonvaccinated siblings. We sought to fully elucidate the safety of rotavirus (RV) vaccination in closed contact circumstance, such as the foster home for future assessment of the vaccine safety in an neonatal intensive care unit. Stool samples were collected from 4 RV vaccinated (160 samples) and 23 unvaccinated (766 samples) infants. RV viral RNA loads were measured using real‐time reverse transcription polymerase chain reaction (RT‐PCR). RV vaccine strain RNA was persistently detected in stool samples collected from the four vaccine recipients and one unvaccinated infant, but not in the stool samples collected from the 22 other unvaccinated infants. The unvaccinated infant who tested positive for the RV vaccine strain was vaccinated prior to enrollment in this study. The quantitative real‐time RT‐PCR data revealed a peak viral RNA load 1 week after vaccination followed by a gradual decrease. The current study suggests that RV vaccination may be safe in a close contact environment because there was limited transmission from RV vaccinated to unvaccinated infants. J. Med. Virol. 89:79–84, 2017. © 2016 Wiley Periodicals, Inc.
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ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.24613