Search Results - "Kosasih, Hansen J"

PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia by Beck, Dominik, Cao, Honghui, Tian, Feng, Huang, Yizhou, Jiang, Miao, Zhao, Han, Tai, Xiaolu, Xu, Wenqian, Kosasih, Hansen J., Kealy, David J., Zhao, Weiye, Taylor, Samuel J., Couttas, Timothy A., Song, Gaoxian, Chacon-Fajardo, Diego, Walia, Yashna, Wang, Meng, Dowle, Adam A., Holding, Andrew N., Bridge, Katherine S., Zhang, Chao, Wang, Jin, Mi, Jian-Qing, Lock, Richard B., de Bock, Charles E., Jing, Duohui

“…The epigenetic landscape plays a critical role in cancer progression, yet its therapeutic potential remains underexplored. Glucocorticoids are essential…”
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Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL by Sadras, Teresa, Jalud, Fatimah B., Kosasih, Hansen J., Horne, Christopher R., Brown, Lauren M., El-Kamand, Sam, de Bock, Charles E., McAloney, Lachlan, Ng, Ashley P., Davidson, Nadia M., Ludlow, Louise E. A., Oshlack, Alicia, Cowley, Mark J., Khaw, Seong L., Murphy, James M., Ekert, Paul G.

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Less is more: Depleting myeloid‐biased HSCs to restore immune function by Kosasih, Hansen J., Bock, Charles E.

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Targeting hyperactive platelet-derived growth factor receptor-β signaling in T-cell acute lymphoblastic leukemia and lymphoma by De Coninck, Stien, De Smedt, Renate, Lintermans, Beatrice, Reunes, Lindy, Kosasih, Hansen J, Reekmans, Alexandra, Brown, Lauren M, Van Roy, Nadine, Palhais, Bruno, Roels, Juliette, Van der Linden, Malaika, Van Dorpe, Jo, Ntziachristos, Panagiotis, Van Delft, Frederik W, Mansour, Marc R, Pieters, Tim, Lammens, Tim, De Moerloose, Barbara, De Bock, Charles E, Goossens, Steven, Van Vlierberghe, Pieter

“…T-cell acute lymphoblastic leukemia (T-ALL) and T-cell lymphoblastic lymphoma (T-LBL) are rare aggressive hematologic malignancies. Current treatment consists…”
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In vitro and in vivo modelling of mutant JAK3/STAT5 signaling in leukemia by Omari, Sofia A., Kosasih, Hansen J., Chung, Thomas, de Bock, Charles E.

“…Mutations within the IL7-R-JAK-STAT signaling pathway are important drivers of T-cell acute lymphoblastic leukemia (T-ALL). Here we describe the important…”
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ALLSorts: a RNA-Seq subtype classifier for B-Cell Acute Lymphoblastic Leukemia by Schmidt, Breon, Brown, Lauren M., Ryland, Georgina L., Lonsdale, Andrew, Kosasih, Hansen J., Ludlow, Louise E., Majewski, Ian J., Blombery, Piers, Ekert, Paul G., Davidson, Nadia M., Oshlack, Alicia

“…B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Subtypes within B-ALL are distinguished by characteristic structural variants…”
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The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia by Toscan, Cara E., McCalmont, Hannah, Ashoorzadeh, Amir, Lin, Xiaojing, Fu, Zhe, Doculara, Louise, Kosasih, Hansen J., Cadiz, Roxanne, Zhou, Anthony, Williams, Sarah, Evans, Kathryn, Khalili, Faezeh, Cai, Ruilin, Yeats, Kristy L., Gifford, Andrew J., Pickford, Russell, Mayoh, Chelsea, Xie, Jinhan, Henderson, Michelle J., Trahair, Toby N., Patterson, Adam V., Smaill, Jeff B., de Bock, Charles E., Lock, Richard B.

“…T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy that expresses high levels of the enzyme aldo-keto reductase family 1…”
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A novel MYB::PAIP1 oncogenic fusion in pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is dependent on BCL2 expression and is sensitive to venetoclax by Kosasih, Hansen J., Healey, Gerry, Brennan, Margs S., Bjelosevic, Stefan, Sadras, Teresa, Jalud, Fatimah B., Ibnat, Tasnia, Ng, Ashley P., Mayoh, Chelsea, Mao, Jie, Tax, Gabor, Ludlow, Louise E. A., Johnstone, Ricky W., Herold, Marco J., Khaw, Seong L., Bock, Charles E., Ekert, Paul G.

“…The huMCL1 mouse strain (human MCL1 gene knocked -into the murine Mcl1 locus) is phenotypically indistinguishable from wild-type C57BL/6 (WT). To determine…”
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Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions by Meyer, Claus, Lopes, Bruno A., Caye-Eude, Aurélie, Cavé, Hélène, Arfeuille, Chloé, Cuccuini, Wendy, Sutton, Rosemary, Venn, Nicola C., Oh, Seung Hwan, Tsaur, Grigory, Escherich, Gabriele, Feuchtinger, Tobias, Kosasih, Hansen J., Khaw, Seong L., Ekert, Paul G., Pombo-de-Oliveira, Maria S., Bidet, Audrey, Djahanschiri, Bardya, Ebersberger, Ingo, Zaliova, Marketa, Zuna, Jan, Zermanova, Zuzana, Juvonen, Vesa, Grümayer, Renate Panzer, Fazio, Grazia, Cazzaniga, Gianni, Larghero, Patrizia, Emerenciano, Mariana, Marschalek, Rolf

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In vivo activity of the second-generation proteasome inhibitor ixazomib against pediatric T-cell acute lymphoblastic leukemia xenografts by Randall, Joanna, Evans, Kathryn, Watts, Ben, Kosasih, Hansen J., Smith, Christopher M., Earley, Eric J., Erickson, Stephen W., Jocoy, Emily L., Bult, Carol J., Teicher, Beverly A., de Bock, Charles E., Smith, Malcolm A., Lock, Richard B.

“…•Ixazomib is an orally available, reversible selective proteasome inhibitor•Ixazomib elicited IC50 values in the low nanomolar range in T-ALL cell models in…”
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Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions by Ryland, Georgina L., Umeda, Masayuki, Holmfeldt, Linda, Lehmann, Sören, Herlin, Morten Krogh, Ma, Jing, Khanlari, Mahsa, Rubnitz, Jeffrey E., Ries, Rhonda E., Kosasih, Hansen J., Ekert, Paul G., Goh, Hwee Ngee, Tiong, Ing S., Grimmond, Sean M., Haferlach, Claudia, Day, Ryan B., Ley, Timothy J., Meshinchi, Soheil, Ma, Xiaotu, Blombery, Piers, Klco, Jeffery M.

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TALLSorts: a T-cell acute lymphoblastic leukemia subtype classifier using RNA-seq expression data by Gu, Allen, Schmidt, Breon, Lonsdale, Andrew, Jalaldeen, Roshan, Kosasih, Hansen J, Brown, Lauren M, Sadras, Teresa, Ekert, Paul G, Oshlack, Alicia

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A Disintegrin and Metalloproteinase with Thrombospondin Motifs-5 (ADAMTS-5) Forms Catalytically Active Oligomers by Kosasih, Hansen J., Last, Karena, Rogerson, Fraser M., Golub, Suzanne B., Gauci, Stephanie J., Russo, Vincenzo C., Stanton, Heather, Wilson, Richard, Lamande, Shireen R., Holden, Paul, Fosang, Amanda J.

“…The metalloproteinase ADAMTS-5 (Adisintegrin and metalloproteinase with thrombospondin motifs) degrades aggrecan, a proteoglycan essential for cartilage…”
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SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia by Brown, Lauren M., Hediyeh-zadeh, Soroor, Sadras, Teresa, Huckstep, Hannah, Sandow, Jarrod J., Bartolo, Ray C., Kosasih, Hansen J., Davidson, Nadia M., Schmidt, Breon, Bjelosevic, Stefan, Johnstone, Ricky, Webb, Andrew I., Khaw, Seong L., Oshlack, Alicia, Davis, Melissa J., Ekert, Paul G.

“…Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expression profile resembling…”
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MLL-TFE3: a novel and aggressive KMT2A fusion identified in infant leukemia by Kosasih, Hansen J., Davidson, Nadia M., Bjelosevic, Stefan, Morrish, Emma, Brennan, Margs S., Oshlack, Alicia, Johnstone, Ricky W., Brumatti, Gabriela, Khaw, Seong L., Ekert, Paul G.

“…•A novel KMT2A-rearrangement, MLL-TFE3, was identified in an infant leukemia patient.•MLL-TFE3 expression produces aggressive leukemia in a mouse model…”
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The AKR1C3-Activated Prodrug, Achm-025, Eradicates Disease in Preclinical Models of Aggressive T-Cell Acute Lymphoblastic Leukemia by Lock, Richard B., Toscan, Cara E, McCalmont, Hannah, Evans, Kathryn, Doculara, Louise, Kosasih, Hansen J, Gifford, Andrew J, Ashoorzadeh, Amir, Lin, Xiaojing, Trahair, Toby N, De Bock, Charles E, Patterson, Adam V, Smaill, Jeff B

“…Introduction: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy that is exceptionally difficult to cure after relapse. T-ALL expresses…”
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