Neurotoxic effects in patients poisoned with organophosphorus pesticides

Abstract In this paper we review neurotoxic disorders appearing in patients poisoned with organophosphorus pesticides. These compounds cause four important neurotoxic effects in humans: the cholinergic syndrome, the intermediate syndrome, organophosphate-induced delayed polyneuropathy (OPIDP) and ch...

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Bibliographic Details
Published in:	Environmental toxicology and pharmacology Vol. 29; no. 3; pp. 195 - 201
Main Authors:	JokanoviAe, Milan, KosanoviAe, Melita
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-05-2010
Subjects:	Chronic exposure Chronic organophosphate-induced neuropsychiatric disorder Emergency Intermediate syndrome Organophosphate-induced neurotoxic effects Organophosphorus Organophosphorus Intermediate syndrome Chronic organophosphate-induced neuropsychiatric disorder Organophosphate-induced neurotoxic effects
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Summary:	Abstract In this paper we review neurotoxic disorders appearing in patients poisoned with organophosphorus pesticides. These compounds cause four important neurotoxic effects in humans: the cholinergic syndrome, the intermediate syndrome, organophosphate-induced delayed polyneuropathy (OPIDP) and chronic organophosphate-induced neuropsychiatric disorder (COPIND). Compared to the cholinergic syndrome, that causes millions of cases of poisoning each year, other disorders involve much smaller numbers of patients. The review is focused on the neurotoxic effects appearing after acute and chronic exposure to organophosphates with emphasis on clinical presentation, pathogenesis, molecular mechanisms, and possibilities for prevention/therapy.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	1382-6689 1872-7077
DOI:	10.1016/j.etap.2010.01.006