Search Results - "Kosanke, Stanley"

TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection by Awasthi, Shanjana, Singh, Bhupinder, Ramani, Vijay, Xie, Jun, Kosanke, Stanley

“…Interaction between surfactant protein-A (SP-A) and toll-like receptor (TLR)4 plays a critical role in host defense. In this work, we studied the host defense…”
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Histopathology of Bordetella pertussis in the Baboon Model by Zimmerman, Lindsey I, Papin, James F, Warfel, Jason, Wolf, Roman F, Kosanke, Stanley D, Merkel, Tod J

“…Pertussis is a severe respiratory disease caused by The classic symptoms of pertussis include paroxysmal coughing with an inspiratory whoop, posttussive…”
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Cardiac myosin-Th17 responses promote heart failure in human myocarditis by Myers, Jennifer M, Cooper, Leslie T, Kem, David C, Stavrakis, Stavros, Kosanke, Stanley D, Shevach, Ethan M, Fairweather, DeLisa, Stoner, Julie A, Cox, Carol J, Cunningham, Madeleine W

“…In human myocarditis and its sequela dilated cardiomyopathy (DCM), the mechanisms and immune phenotype governing disease and subsequent heart failure are not…”
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Influence of the estrus cycle of the mouse on the disposition of SHetA2 after vaginal administration by Mahjabeen, Sanjida, Hatipoglu, Manolya Kukut, Benbrook, Doris M., Kosanke, Stanley D., Garcia-Contreras, David, Garcia-Contreras, Lucila

“…[Display omitted] SHetA2 is a novel compound with the potential to treat cervical dysplasia, but has poor water solubility. A vaginal suppository formulation…”
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The IFIH1-A946T risk variant promotes diabetes in a sex-dependent manner by Stock, Amanda J, Gonzalez Paredes, Pierina, de Almeida, Luciana Previato, Kosanke, Stanley D, Chetlur, Srinivaas, Budde, Hannah, Wakenight, Paul, Zwingman, Theresa A, Rosen, Aaron B I, Allenspach, Eric J, Millen, Kathleen J, Buckner, Jane H, Rawlings, David J, Gorman, Jacquelyn A

“…Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and…”
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DMBA promotes ErbB2‑mediated carcinogenesis via ErbB2 and estrogen receptor pathway activation and genomic instability by Ma, Zhikun, Kim, Young Mi, Howard, Erin W, Feng, Xiaoshan, Kosanke, Stanley D, Yang, Shihe, Jiang, Yunbo, Parris, Amanda B, Cao, Xia, Li, Shibo, Yang, Xiaohe

“…Environmental factors, including 7,12‑dimethylbenz[a]anthracene (DMBA) exposure, and genetic predisposition, including ErbB2 overexpression/amplification, have…”
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Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide by Awasthi, Shanjana, Rahman, Negar, Rui, Bin, Kumar, Gaurav, Awasthi, Vibhudutta, Breshears, Melanie, Kosanke, Stanley

“…A surfactant protein-A-derived peptide, which we call SPA4 peptide (amino acids: GDFRYSDGTPVNYTNWYRGE), alleviates lung infection and inflammation. This study…”
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Mimicry and Antibody-Mediated Cell Signaling in Autoimmune Myocarditis by Li, Ya, Heuser, Janet S, Cunningham, Luke C, Kosanke, Stanley D, Cunningham, Madeleine W

“…The mechanisms by which autoantibodies against cardiac myosin (CM) may lead to heart dysfunction is unknown. We show that autoantibodies to CM in anti-CM sera…”
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Safety assessment of the dietary supplement OxyELITE™ Pro (New Formula) in inbred and outbred mouse strains by Miousse, Isabelle R., Skinner, Charles M., Lin, Haixia, Ewing, Laura E., Kosanke, Stanley D., Williams, D. Keith, Avula, Bharathi, Khan, Ikhlas A., ElSohly, Mahmoud A., Gurley, Bill J., Koturbash, Igor

“…Herbal dietary supplements have gained wide acceptance as alternatives to conventional therapeutic agents despite concerns regarding their efficacy and safety…”
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A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation by Ramani, Vijay, Madhusoodhanan, Rakhesh, Kosanke, Stanley, Awasthi, Shanjana

“…The interaction between surfactant protein-A (SP-A) and TLR4 is important for host defense. We have recently identified an SPA4 peptide region from the…”
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Suppression and activation of the malignant phenotype by extracellular matrix in xenograft models of bladder cancer: a model for tumor cell "dormancy" by Hurst, Robert E, Hauser, Paul J, Kyker, Kimberly D, Heinlen, Jonathan E, Hodde, Jason P, Hiles, Michael C, Kosanke, Stanley D, Dozmorov, Mikhail, Ihnat, Michael A

“…A major problem in cancer research is the lack of a tractable model for delayed metastasis. Herein we show that cancer cells suppressed by SISgel, a…”
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Effects of SPA4 peptide on lipopolysaccharide‐disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury by Chowdhury, Asif Alam, Godbole, Nachiket M., Chataut, Neha, Kosanke, Stanley, Rodgers, Karla, Awasthi, Shanjana

“…Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural…”
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Defective selection of thymic regulatory T cells accompanies autoimmunity and pulmonary infiltrates in Tcra-deficient mice double transgenic for human La/Sjögren's syndrome-B and human La-specific TCR by Yaciuk, Jane C, Pan, Yujun, Schwarz, Karen, Pan, Zi-Jian, Maier-Moore, Jacen S, Kosanke, Stanley D, Lawrence, Christina, Farris, A Darise

“…A human La/Sjögren's syndrome-B (hLa)-specific TCR/hLa neo-self-Ag double-transgenic (Tg) mouse model was developed and used to investigate cellular tolerance…”
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Efficacy of a Gal-lectin subunit vaccine against experimental Entamoeba histolytica infection and colitis in baboons ( Papio sp.) by Abd Alla, Mohamed D, Wolf, Roman, White, Gary L, Kosanke, Stanley D, Cary, David, Verweij, Jaco J, Zhang, Mie-Jie, Ravdin, Jonathan I

“…Highlights ► Developed a new experimental model of E. histolytica infection in baboons. ► E. histolytica infection and inflammatory colitis was sustained for…”
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Short-term early exposure to lapatinib confers lifelong protection from mammary tumor development in MMTV-erbB-2 transgenic mice by Ma, Zhikun, Parris, Amanda B, Xiao, Zhengzheng, Howard, Erin W, Kosanke, Stanley D, Feng, Xiaoshan, Yang, Xiaohe

“…Although chemopreventative agents targeting the estrogen/estrogen receptor (ER) pathway have been effective for ER breast cancers, prevention of hormone…”
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Infant baboons infected with respiratory syncytial virus develop clinical and pathological changes that parallel those of human infants by Papin, James F, Wolf, Roman F, Kosanke, Stanley D, Jenkins, Justin D, Moore, Sara N, Anderson, Michael P, Welliver, Sr, Robert C

“…Respiratory syncytial virus (RSV) infection of the lower respiratory tract is the leading cause of respiratory failure among infants in the United States of…”
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IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes by Kirvan, Christine A, Canini, Heather, Swedo, Susan E, Hill, Harry, Veasy, George, Jankelow, David, Kosanke, Stanley, Ward, Kent, Zhao, Yan D, Alvarez, Kathy, Hedrick, Andria, Cunningham, Madeleine W

“…Antecedent group A streptococcal pharyngitis is a well-established cause of acute rheumatic fever (ARF) where rheumatic valvular heart disease (RHD) and…”
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Corrigendum: IgG2 rules: N-acetyl-β-D-glucosamine-specific IgG2 and Th17/Th1 cooperation may promote the pathogenesis of acute rheumatic heart disease and be a biomarker of the autoimmune sequelae of Streptococcus pyogenes by Kirvan, Christine A., Canini, Heather, Swedo, Susan E., Hill, Harry, Veasy, George, Jankelow, David, Kosanke, Stanley, Ward, Kent, Zhao, Yan D., Alvarez, Kathy, Hedrick, Andria, Cunningham, Madeleine W.

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Mechanism of anti-glioma activity and in vivo efficacy of the cannabinoid ligand KM-233 by Gurley, Steven N., Abidi, Ammaar H., Allison, Patrick, Guan, Peihong, Duntsch, Christopher, Robertson, Jon H., Kosanke, Stanley D., Keir, Stephen T., Bigner, Darell D., Elberger, Andrea J., Moore, Bob M.

“…Glioblastoma multiforme (GBM) is the most common and devastating form of primary central nervous system malignancy. The prognosis for patients diagnosed with…”
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Analysis of TMEFF2 allografts and transgenic mouse models reveals roles in prostate regeneration and cancer by Corbin, Joshua M., Overcash, Ryan F., Wren, Jonathan D., Coburn, Anita, Tipton, Greg J., Ezzell, Jennifer A., McNaughton, Kirk K., Fung, Kar-Ming, Kosanke, Stanley D., Ruiz-Echevarria, Maria J.

“…BACKGROUND Previous results from our lab indicate a tumor suppressor role for the transmembrane protein with epidermal growth factor and two follistatin motifs…”
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