Search Results - "Kos, Claudine H"

Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone―Independent Hypocalciuria by TOKA, Hakan R, AL-ROMAIH, Khaldoun, KOSHY, Jacob M, DIBARTOLO, Salvatore, KOS, Claudine H, QUINN, Stephen J, CURHAN, Gary C, MOUNT, David B, BROWN, Edward M, POLLAK, Martin R

“…Rare loss-of-function mutations in the calcium-sensing receptor (Casr) gene lead to decreased urinary calcium excretion in the context of parathyroid hormone…”
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Regulation of axonal and dendritic growth by the extracellular calcium-sensing receptor by Riccardi, Daniela, Davies, Alun M, Vizard, Thomas N, O'Keeffe, Gerard W, Gutierrez, Humberto, Kos, Claudine H

“…The extracellular calcium-sensing receptor (CaSR) monitors the systemic, extracellular, free ionized-calcium level ([Ca 2+ ] o ) in organs involved in systemic…”
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The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone by Kos, Claudine H, Karaplis, Andrew C, Peng, Ji-Bin, Hediger, Matthias A, Goltzman, David, Mohammad, Khalid S, Guise, Theresa A, Pollak, Martin R

“…The extracellular calcium-sensing receptor (CaR; alternate gene names, CaR or Casr) is a membrane-spanning G protein-coupled receptor. CaR is highly expressed…”
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Alpha-actinin-4-mediated FSGS: an inherited kidney disease caused by an aggregated and rapidly degraded cytoskeletal protein by Yao, June, Le, Tu Cam, Kos, Claudine H, Henderson, Joel M, Allen, Phillip G, Denker, Bradley M, Pollak, Martin R

“…Focal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults such…”
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Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor by Scadden, David T, Adams, Gregor B, Chabner, Karissa T, Alley, Ian R, Olson, Douglas P, Szczepiorkowski, Zbigniew M, Poznansky, Mark C, Kos, Claudine H, Pollak, Martin R, Brown, Edward M

“…During mammalian ontogeny, haematopoietic stem cells (HSCs) translocate from the fetal liver to the bone marrow, where haematopoiesis occurs throughout…”
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Cre/loxP system for generating tissue-specific knockout mouse models by KOS, Claudine H

“…Alteration of the mouse genome by conventional transgenic and gene-targeted approaches has greatly facilitated studies of gene function. However, a gene…”
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Marked Disturbance of Calcium Homeostasis in Mice With Targeted Disruption of the Trpv6 Calcium Channel Gene by Bianco, Suzy DC, Peng, Ji‐Bin, Takanaga, Hitomi, Suzuki, Yoshiro, Crescenzi, Alessandra, Kos, Claudine H, Zhuang, Liyan, Freeman, Michael R, Gouveia, Cecilia HA, Wu, Jiangping, Luo, Hongyu, Mauro, Theodora, Brown, Edward M, Hediger, Matthias A

“…We report the phenotype of mice with targeted disruption of the Trpv6 (Trpv6 KO) epithelial calcium channel. The mice exhibit disordered Ca2+ homeostasis,…”
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Mice deficient in alpha-actinin-4 have severe glomerular disease by Kos, Claudine H, Le, Tu Cam, Sinha, Sumita, Henderson, Joel M, Kim, Sung Han, Sugimoto, Hikaru, Kalluri, Raghu, Gerszten, Robert E, Pollak, Martin R

“…Dominantly inherited mutations in ACTN4, which encodes alpha-actinin-4, cause a form of human focal and segmental glomerulosclerosis (FSGS). By homologous…”
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Methods in Nutrition Science: Cre/loxP System for Generating Tissue-specific Knockout Mouse Models by Kos, Claudine H.

“…Editor's note: From time to time, we take the opportunity in Nutrition Reviews to highlight a particularly exciting application of sophisticated methodological…”
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Hereditary hypophosphatemic rickets with hypercalciuria is not caused by mutations in the Na/Pi cotransporter NPT2 gene by JONES, Andrew O, TZENOVA, Jordana, RICE, Allan, ANDERSON, Donald, MORGAN, Kenneth, FUJIWARA, T. Mary, TENENHOUSE, Harriet S, FRAPPIER, Danielle, CRUMLEY, M. Joyce, ROSLIN, Nicole M, KOS, Claudine H, TIEDER, Martin, LANGMAN, Craig B, PROESMANS, Willem, CARPENTER, Thomas O

“…Hereditary hypophosphatemic rickets with hypercalciuria (HHRH), a renal phosphate (Pi) wasting disease first described in an extended Bedouin kindred, is…”
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Mice deficient in alpha -actinin-4 have severe glomerular disease by Kos, CH, Le, T C, Sinha, S, Henderson, J M, Kim, SH, Sugimoto, H, Kalluri, R, Gerszten, R E, Pollak, M R

“…Dominantly inherited mutations in ACTN4, which encodes alpha -actinin-4, cause a form of human focal and segmental glomerulosclerosis (FSGS). By homologous…”
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High resolution mapping of the renal sodium-phosphate cotransporter gene (NPT2) confirms its localization to human chromosome 5q35 by MCPHERSON, J. D, KRANE, M. C, WAGNER-MCPHERSON, C. B, KOS, C. H, TENENHOUSE, H. S

“…The precise chromosomal localization of the type II renal-specific Na+-phosphate (Pi) cotransporter (NPT2) gene (gene symbol SLC17A2) is necessary for the…”
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The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone by Kos, CH, Karaplis, A C, Peng, Ji-Bin, Hediger, MA, Goltzman, D, Mohammad, K S, Guise, T A, Pollak, M R

“…The extracellular calcium-sensing receptor (CAR; alternate gene names, CaR or Casr) is a membrane-spanning G protein-coupled receptor. CaR is highly expressed…”
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Mice deficient in [alpha]-actinin-4 have severe glomerular disease by Kos, Claudine H, Tu Cam Le, Sinha, Sumita, Henderson, Joel M

“…Dominantly inherited mutations in ACTN4, which encodes alpha-actinin-4, cause a form of human focal and segmental glomerulosclerosis (FSGS). By homologous…”
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[alpha]-Actinin-4-Mediated FSGS: An Inherited Kidney Disease Caused by an Aggregated and Rapidly Degraded Cytoskeletal Protein: e167 by Yao, June, Le, Tu Cam, Kos, Claudine H, Henderson, Joel M, Allen, Phillip G, Denker, Bradley M, Pollak, Martin R

“…Focal segmental glomerulosclerosis (FSGS) is a common pattern of renal injury, seen as both a primary disorder and as a consequence of underlying insults such…”
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Localization of a renal sodium-phosphate cotransporter gene to human chromosome 5q35 by Kos, C H, Tihy, F, Econs, M J, Murer, H, Lemieux, N, Tenenhouse, H S

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The role of the renal sodium -dependent phosphate cotransporter genes, NPT1 and NPT2, in inherited hypophosphatemias by Kos, Claudine H

“…This thesis includes three studies examining the role of the type I (NPT1) and type II (NPT2) renal sodium (Na+)-phosphate (Pi) cotransporter genes in…”
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