Implanon ® contraceptive implants: effects on carbohydrate metabolism

Implanon ® contraceptive implants: effects on carbohydrate metabolism

The objective of the study was to assess the possible differences in effects of Implanon ® and Norplant ® implants on carbohydrate metabolism. This is a 2-year open randomized study of 80 implant (Implanon and Norplant) acceptors. Oral glucose tolerance test (OGTT) was performed before implant inser...

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Bibliographic Details
Published in:Contraception (Stoneham) Vol. 63; no. 3; pp. 137 - 141
Main Authors: Biswas, Arijit, A.C. Viegas, Osborne, Coeling Bennink, Herjan J.T, Korver, Tjeed, Ratnam, Shan S
Format: Journal Article
Language:English
Published: New York, NY Elsevier Inc 01-03-2001
Elsevier Science
Subjects:
3-ketodesogestrel
Adolescent
Adult
Biological and medical sciences
Birth control
Blood Glucose - analysis
Blood Glucose - metabolism
Contraceptive Agents, Female - adverse effects
Desogestrel
Drug Implants
Etonogestrel
Fasting
Female
Glucose Tolerance Test
Glycated Hemoglobin A - analysis
Gynecology. Andrology. Obstetrics
Hormonal contraception
Humans
Implanon
Implants
Insulin - blood
Insulin Resistance
Kinetics
Levonorgestrel - adverse effects
Medical sciences
Progestins
Vinyl Compounds - adverse effects
Etonogestrel
3-ketodesogestrel
Implanon
Implants
Progestins
Human
Implant
Controlled release form
Rod
Levonorgestrel
Glucose tolerance test
Glucose
Hemoglobin A1
Metabolism
Insulin
Progestagen
EVA
Dosage form
Female
Subcutaneous administration
Contraceptive
Carbohydrate
Sex steroid hormone
Comparative study
Glycemia
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Summary:The objective of the study was to assess the possible differences in effects of Implanon ® and Norplant ® implants on carbohydrate metabolism. This is a 2-year open randomized study of 80 implant (Implanon and Norplant) acceptors. Oral glucose tolerance test (OGTT) was performed before implant insertion and at 6, 12, and 24 months after implant insertion. Glycosylated hemoglobin A 1C was measured in fasting samples and plasma samples during OGTT were tested for glucose and insulin levels. There was a significant increase in the area under the curve for both glucose and insulin during OGTT within each group with increasing duration of use. However, there was no significant change in the fasting plasma glucose values. There was no significant difference in the carbohydrate parameters between the two groups during implant use, except for a minimal but statistically significant rise in fasting glycosylated hemoglobin A 1C levels at 24 months in the Implanon group. Both implants appear to induce mild insulin resistance but no significant change in serum glucose levels. These alterations in carbohydrate metabolism should have no clinical significance in healthy women.
ISSN:0010-7824
1879-0518
DOI:10.1016/S0010-7824(01)00182-2