Search Results - "Kortylewicz, Z. P."

Strand Breaks after the Decay of Iodine-125 in Proximity to Plasmid pBR322 DNA by Sahu, S. K., Kortylewicz, Z. P., Baranowska-Kortylewicz, J., Taube, R. A., Adelstein, S. J., Kassis, A. I.

“…To elucidate the kinetics of DNA strand breaks caused by low-energy Auger electron emitters in proximity to DNA molecules, we synthesized 125 I-labeled…”
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Phosphoramidate peptide inhibitors of human skin fibroblast collagenase by Kortylewicz, Zbigniew P, Galardy, Richard E

“…An extensive series of N-(monoethylphosphoryl)peptides was synthesized and their inhibition of purified human skin fibroblast collagenase examined. At the…”
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Colon-specific prodrugs of 5-radioiodo-2'-deoxyuridine by Baranowska-Kortylewicz, J, Kortylewicz, Z P, Hoffman, D, Winoto, A, Lai, J, Dalrymple, G V

“…Two glycoside-based prodrugs, 125IUdR-5'-beta-D-glucopyranoside and 125IUdR-5'-beta-D-galactopyranoside, were synthesized. This selection was dictated by the…”
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Inhibition of carboxypeptidase A by aldehyde and ketone substrate analogs by Galardy, Richard E, Kortylewicz, Zbigniew P

“…DL-2-Benzyl-3- formylpropanoic acid ( XIVb ) is a competitive inhibitor of carboxypeptidase A with an apparent Ki of 0.48 microM at pH 7.5 in 50 mM Tris…”
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Inhibitors of angiotensin-converting enzyme containing a tetrahedral arsenic atom by Galardy, R E, Kortylewicz, Z P

“…A series of tetrahedral oxo acids of Group VA and VIA elements and of silicon and boron were examined as inhibitors of angiotensin-converting enzyme. Arsenate…”
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alpha.-Bromo ketone substrate analogs are powerful reversible inhibitors of carboxypeptidase A by Galardy, Richard E, Kortylewicz, Zbigniew P

“…The aldehyde (RS)-2-benzyl-4-oxobutanoic acid, which is 25% hydrated at pH 7.5, has recently been shown to be a strong reversible competitive inhibitor of…”
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Synthesis of a docosapeptide comprising the hydrophobic membrane spanning region of glycophorin A by Galardy, R E, Kortylewicz, Z P

“…The docosapeptide which constitutes the membrane spanning region (amino acid residues 73-94) of the human red blood cell protein glycophorin A has been…”
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Inhibition of angiotensin converting enzyme by phosphonic amides and phosphonic acids by Galardy, Richard E, Kontoyiannidou-Ostrem, Voula, Kortylewicz, Zbigniew P

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Inhibition of human skin fibroblast collagenase by phosphorus-containing peptides by Galardy, R E, Grobelny, D, Kortylewicz, Z P, Poncz, L

“…Substitution of the phosphonamidate linkage (PO2-NH) for the peptide bond (CO-NH) in substrate-like sequences produces inhibitors of human skin fibroblast…”
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Effect of platelet-derived growth factor receptor-β inhibition with STI571 on radioimmunotherapy by BARANOWSKA-KORTYLEWICZ, Janina, ABE, Michio, PIETRA, Kristian, KORTYLEWICZ, Zbigniew P, KURIZAKI, Takashi, NEARMAN, Jessica, PAULSSON, Janna, MOSLEY, R. Lee, ENKE, Charles A, ÖSTMAN, Arne

“…Whereas radioimmunotherapy of hematologic malignancies has evolved into a viable treatment option, the responses of solid tumors to radioimmunotherapy are…”
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Radiolabeled Constructs for Evaluation of the Asialoglycoprotein Receptor Status and Hepatic Functional Reserves by Abe, Michio, Lai, Jing, Kortylewicz, Zbigniew P, Nagata, Hideo, Fox, Ira J, Enke, Charles A, Baranowska-Kortylewicz, Janina

“…Transplantation of isolated hepatocytes may eventually replace a whole liver transplantation for the treatment of selected liver metabolic disorders and acute…”
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Effects of STI571 on radioimmunotherapy of colorectal cancer by Baranowska-Kortylewicz, J, Abe, M, Kurizaki, T, Pietras, K, Ostman, A, Kortylewicz, ZP, Enke, CA

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Phthaloyl-glycylP-isoleucyl-tryptophan benzylamide is a potent inhibitor of human skin fibroblast collagenase with a Ki of 25 nM by Kortylewicz, Z P, Galardy, R E

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Prodrugs in site-selective delivery of radiopharmaceuticals by Baranowska-Kortylewicz, J, Kortylewicz, Z P, Hoffman, D, Dalrymple, G V

“…This paper reviews basic rules for the design of site-selective prodrugs and various modes of their activation with particular emphasis on the applications of…”
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