Search Results - "Kortekaas, Rosa K"

Therapeutic Targeting of IL-11 for Chronic Lung Disease by Kortekaas, Rosa K., Burgess, Janette K., van Orsoy, Roël, Lamb, David, Webster, Megan, Gosens, Reinoud

“…Interleukin (IL)-11 was originally recognized as an immunomodulatory and hematopoiesis-inducing cytokine. However, although IL-11 is typically not found in…”
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TNF signaling mediates lipopolysaccharide-induced lung epithelial progenitor cell responses in mouse lung organoids by Li, Dan, Kortekaas, Rosa K., Douglas, Kelly B.I., Douwenga, Wanda, Eisel, Ulrich L.M., Melgert, Barbro N., Gosens, Reinoud, Schmidt, Martina

“…Bacterial respiratory infections are a major global health concern, often leading to lung injury and triggering lung repair mechanisms. Endogenous epithelial…”
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The disruptive effects of COPD exacerbation-associated factors on epithelial repair responses by Kortekaas, Rosa K, Geillinger-Kästle, Kerstin E, Fuentes-Mateos, Rocío, van Orsoy, Roël, Al-Alyan, Nakaa, Burgess, Janette K, Gosens, Reinoud

“…Exacerbations of chronic obstructive pulmonary disease (COPD) increase mortality risk and can lead to accelerated loss of lung function. The increased…”
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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiation by Ng-Blichfeldt, John-Poul, Schrik, Anneke, Kortekaas, Rosa K., Noordhoek, Jacobien A., Heijink, Irene H., Hiemstra, Pieter S., Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud

“…Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive pulmonary disease…”
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Interleukin-11 disrupts alveolar epithelial progenitor function by Kortekaas, Rosa K, Geillinger-Kästle, Kerstin E, Borghuis, Theo, Belharch, Kaoutar, Webster, Megan, Timens, Wim, Burgess, Janette K, Gosens, Reinoud

“…Interleukin-11 (IL-11) is linked to the pathogenesis of idiopathic pulmonary fibrosis (IPF), since IL-11 induces myofibroblast differentiation and stimulates…”
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TGF-β activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation by Ng-Blichfeldt, John-Poul, de Jong, Tristan, Kortekaas, Rosa K, Wu, Xinhui, Lindner, Michael, Guryev, Victor, Hiemstra, Pieter S, Stolk, Jan, Königshoff, Melanie, Gosens, Reinoud

“…Transforming growth factor-β (TGF-β)-induced fibroblast-to-myofibroblast differentiation contributes to remodeling in chronic obstructive pulmonary disease and…”
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The soluble factor milieu in idiopathic pulmonary fibrosis dysregulates epithelial differentiation by Kortekaas, Rosa K., Geillinger‐Kästle, Kerstin E., Fuentes‐Mateos, Rocío, Schönleber, Anita, Koog, Luke, Elferink, Robin A. B., Al‐Alyan, Nakaa, Burgess, Janette K., Gosens, Reinoud

“…In idiopathic pulmonary fibrosis (IPF), epithelial abnormalities are present including bronchiolization and alveolar cell dysfunction. We hypothesized that the…”
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Retinoic acid signaling balances adult distal lung epithelial progenitor cell growth and differentiationResearch in context by John-Poul Ng-Blichfeldt, Anneke Schrik, Rosa K. Kortekaas, Jacobien A. Noordhoek, Irene H. Heijink, Pieter S. Hiemstra, Jan Stolk, Melanie Königshoff, Reinoud Gosens

“…Background: Despite compelling data describing pro-regenerative effects of all-trans retinoic acid (ATRA) in pre-clinical models of chronic obstructive…”
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