Search Results - "Korsmeyer, Stanley J."

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members by Scorrano, Luca, Korsmeyer, Stanley J.

“…A crucial amplificatory event in several apoptotic cascades is the nearly complete release of cytochrome c from mitochondria. Proteins of the BCL-2 family…”
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Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide by Bernal, Federico, Tyler, Andrew F, Korsmeyer, Stanley J, Walensky, Loren D, Verdine, Gregory L

“…The p53-hDM2 protein interaction is a validated therapeutic target in cancer. We report the synthesis of stabilized alpha-helix of p53 (SAH-p53) compounds that…”
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Apoptosis in the development and maintenance of the immune system by Korsmeyer, Stanley J, Opferman, Joseph T

“…Programmed cell death is essential for the development and maintenance of cellular homeostasis of the immune system. The Bcl-2 family of proteins comprises…”
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Cyclophilin D Is a Component of Mitochondrial Permeability Transition and Mediates Neuronal Cell Death after Focal Cerebral Ischemia by Schinzel, Anna C, Takeuchi, Osamu, Huang, Zhihong, Fisher, Jill K, Zhou, Zhipeng, Rubens, Jeffery, Hetz, Claudio, Danial, Nika N, Moskowitz, Michael A, Korsmeyer, Stanley J

“…Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix calcium and is characterized by the opening of the PT pore (PTP)…”
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Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix by Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., Wagner, Gerhard, Verdine, Gregory L., Korsmeyer, Stanley J.

“…BCL-2 family proteins constitute a critical control point for the regulation of apoptosis. Protein interaction between BCL-2 members is a prominent mechanism…”
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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics by Letai, Anthony, Bassik, Michael C., Walensky, Loren D., Sorcinelli, Mia D., Weiler, Solly, Korsmeyer, Stanley J.

“…The “BH3-only” proteins of the BCL-2 family require “multidomain” proapoptotic members BAX and BAK to release cytochrome c from mitochondria and kill cells. We…”
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Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells by Opferman, Joseph T, Iwasaki, Hiromi, Ong, Christy C, Suh, Heikyung, Mizuno, Shin-ichi, Akashi, Koichi, Korsmeyer, Stanley J

“…Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. However, the specific BCL-2 family member(s) that regulate HSC homeostasis are not…”
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BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis by Scorrano, Luca, Oakes, Scott A., Opferman, Joseph T., Cheng, Emily H., Sorcinelli, Mia D., Pozzan, Tullio, Korsmeyer, Stanley J.

“…BAX and BAK are "multidomain" proapoptotic proteins that initiate mitochondrial dysfunction but also localize to the endoplasmic reticulum (ER). Mouse…”
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p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis by Kirsch, David G, Santiago, Philip M, di Tomaso, Emmanuelle, Sullivan, Julie M, Hou, Wu-Shiun, Dayton, Talya, Jeffords, Laura B, Sodha, Pooja, Mercer, Kim L, Cohen, Rhianna, Takeuchi, Osamu, Korsmeyer, Stanley J, Bronson, Roderick T, Kim, Carla F, Haigis, Kevin M, Jain, Rakesh K, Jacks, Tyler

“…Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells…”
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Survival Factor-Induced Extracellular Signal-Regulated Kinase Phosphorylates BIM, Inhibiting Its Association with BAX and Proapoptotic Activity by Harada, Hisashi, Quearry, Bonnie, Ruiz-Vela, Antonio, Korsmeyer, Stanley J.

“…The "BH3-only" proapoptotic BCL-2 family members initiate the intrinsic apoptotic pathway. A small interfering RNA knockdown of BIM confirms this BH3-only…”
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Proapoptotic BAX and BAK Regulate the Type 1 Inositol Trisphosphate Receptor and Calcium Leak from the Endoplasmic Reticulum by Oakes, Scott A., Scorrano, Luca, Opferman, Joseph T., Bassik, Michael C., Nishino, Mari, Pozzan, Tullio, Korsmeyer, Stanley J.

“…Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and for maintaining the endoplasmic…”
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A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis by Scorrano, Luca, Ashiya, Mona, Buttle, Karolyn, Weiler, Solly, Oakes, Scott A., Mannella, Carmen A., Korsmeyer, Stanley J.

“…The mechanism during apoptosis by which cytochrome c is rapidly and completely released in the absence of mitochondrial swelling is uncertain. Here, we show…”
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Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival by Woodland, Robert T., Fox, Casey J., Schmidt, Madelyn R., Hammerman, Peter S., Opferman, Joseph T., Korsmeyer, Stanley J., Hilbert, David M., Thompson, Craig B.

“…We investigated the mechanism by which B lymphocyte stimulator (BLyS)/BAFF, a tumor necrosis factor superfamily ligand, promotes B-cell survival and resistance…”
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VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis by Emily H. -Y. Cheng, Sheiko, Tatiana V., Fisher, Jill K., Craigen, William J., Korsmeyer, Stanley J.

“…The multidomain proapoptotic molecules BAK or BAX are required to initiate the mitochondrial pathway of apoptosis. How cells maintain the potentially lethal…”
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A spatially and temporally restricted mouse model of soft tissue sarcoma by Jacks, Tyler, Kirsch, David G, Dinulescu, Daniela M, Miller, John B, Grimm, Jan, Santiago, Philip M, Young, Nathan P, Nielsen, G Petur, Quade, Bradley J, Chaber, Christopher J, Schultz, Christian P, Takeuchi, Osamu, Bronson, Roderick T, Crowley, Denise, Korsmeyer, Stanley J, Yoon, Sam S, Hornicek, Francis J, Weissleder, Ralph

“…Soft tissue sarcomas are mesenchymal tumors that are fatal in approximately one-third of patients. To explore mechanisms of sarcoma pathogenesis, we have…”
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A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway by Zamorano, Sebastián, Rojas-Rivera, Diego, Lisbona, Fernanda, Parra, Valentina, Court, Felipe A, Villegas, Rosario, Cheng, Emily H, Korsmeyer, Stanley J, Lavandero, Sergio, Hetz, Claudio

“…Most intrinsic death signals converge into the activation of pro-apoptotic BCL-2 family members BAX and BAK at the mitochondria, resulting in the release of…”
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p70S6 Kinase Signals Cell Survival as well as Growth, Inactivating the Pro-Apoptotic Molecule BAD by Harada, Hisashi, Andersen, Jens S., Mann, Matthias, Terada, Naohiro, Korsmeyer, Stanley J.

“…Cytokines often deliver simultaneous, yet distinct, cell growth and cell survival signals. The 70-kDa ribosomal protein S6 kinase (p70S6K) is known to regulate…”
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BCL-2 FAMILY: Regulators of Cell Death by Chao, Debra T, Korsmeyer, Stanley J

“…An expanding family of BCL-2 related proteins share homology, clustered within four conserved regions, namely BCL-2 homology (BH1-4) domains, which control the…”
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Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death by Wei, Michael C., Zong, Wei-Xing, Emily H. -Y. Cheng, Lindsten, Tullia, Panoutsakopoulou, Vily, Ross, Andrea J., Roth, Kevin A., MacGregor, Grant R., Thompson, Craig B., Korsmeyer, Stanley J.

“…Multiple death signals influence mitochondria during apoptosis, yet the critical initiating event for mitochondrial dysfunction in vivo has been unclear. tBID,…”
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Essential Role of BAX, BAK in B Cell Homeostasis and Prevention of Autoimmune Disease by Takeuchi, Osamu, Fisher, Jill, Suh, Heikyung, Harada, Hisashi, Malynn, Barbara A., Korsmeyer, Stanley J., Cantor, Harvey

“…B cell homeostasis is maintained by a balance between the continual generation of new cells and their elimination. Here we show proapoptotic BCL-2 family…”
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