Search Results - "Korsmeyer, Stanley"

Mechanisms of cytochrome c release by proapoptotic BCL-2 family members by Scorrano, Luca, Korsmeyer, Stanley J.

“…A crucial amplificatory event in several apoptotic cascades is the nearly complete release of cytochrome c from mitochondria. Proteins of the BCL-2 family…”
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Cell Death: Critical Control Points by Danial, Nika N, Korsmeyer, Stanley J

“…Programmed cell death is a distinct genetic and biochemical pathway essential to metazoans. An intact death pathway is required for successful embryonic…”
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Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members by Certo, Michael, Moore, Victoria Del Gaizo, Nishino, Mari, Wei, Guo, Korsmeyer, Stanley, Armstrong, Scott A., Letai, Anthony

“…We show that the antiapoptotic proteins BCL-2, BCL-XL, MCL-1, BFL-1, and BCL-w each bear a unique pattern of interaction with a panel of peptides derived from…”
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Reactivation of the p53 Tumor Suppressor Pathway by a Stapled p53 Peptide by Bernal, Federico, Tyler, Andrew F, Korsmeyer, Stanley J, Walensky, Loren D, Verdine, Gregory L

“…The p53-hDM2 protein interaction is a validated therapeutic target in cancer. We report the synthesis of stabilized alpha-helix of p53 (SAH-p53) compounds that…”
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Apoptosis in the development and maintenance of the immune system by Korsmeyer, Stanley J, Opferman, Joseph T

“…Programmed cell death is essential for the development and maintenance of cellular homeostasis of the immune system. The Bcl-2 family of proteins comprises…”
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Cyclophilin D Is a Component of Mitochondrial Permeability Transition and Mediates Neuronal Cell Death after Focal Cerebral Ischemia by Schinzel, Anna C, Takeuchi, Osamu, Huang, Zhihong, Fisher, Jill K, Zhou, Zhipeng, Rubens, Jeffery, Hetz, Claudio, Danial, Nika N, Moskowitz, Michael A, Korsmeyer, Stanley J

“…Mitochondrial permeability transition (PT) is a phenomenon induced by high levels of matrix calcium and is characterized by the opening of the PT pore (PTP)…”
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Activation of Apoptosis in vivo by a Hydrocarbon-Stapled BH3 Helix by Walensky, Loren D., Kung, Andrew L., Escher, Iris, Malia, Thomas J., Barbuto, Scott, Wright, Renee D., Wagner, Gerhard, Verdine, Gregory L., Korsmeyer, Stanley J.

“…BCL-2 family proteins constitute a critical control point for the regulation of apoptosis. Protein interaction between BCL-2 members is a prominent mechanism…”
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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics by Letai, Anthony, Bassik, Michael C., Walensky, Loren D., Sorcinelli, Mia D., Weiler, Solly, Korsmeyer, Stanley J.

“…The “BH3-only” proteins of the BCL-2 family require “multidomain” proapoptotic members BAX and BAK to release cytochrome c from mitochondria and kill cells. We…”
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A Stapled BID BH3 Helix Directly Binds and Activates BAX by Walensky, Loren D., Pitter, Kenneth, Morash, Joel, Oh, Kyoung Joon, Barbuto, Scott, Fisher, Jill, Smith, Eric, Verdine, Gregory L., Korsmeyer, Stanley J.

“…BAX is a multidomain proapoptotic BCL-2 family protein that resides in the cytosol until activated by an incompletely understood trigger mechanism, which…”
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Obligate Role of Anti-Apoptotic MCL-1 in the Survival of Hematopoietic Stem Cells by Opferman, Joseph T, Iwasaki, Hiromi, Ong, Christy C, Suh, Heikyung, Mizuno, Shin-ichi, Akashi, Koichi, Korsmeyer, Stanley J

“…Apoptosis is important in controlling hematopoietic stem cell (HSC) numbers. However, the specific BCL-2 family member(s) that regulate HSC homeostasis are not…”
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BAX and BAK Regulation of Endoplasmic Reticulum Ca2+: A Control Point for Apoptosis by Scorrano, Luca, Oakes, Scott A., Opferman, Joseph T., Cheng, Emily H., Sorcinelli, Mia D., Pozzan, Tullio, Korsmeyer, Stanley J.

“…BAX and BAK are "multidomain" proapoptotic proteins that initiate mitochondrial dysfunction but also localize to the endoplasmic reticulum (ER). Mouse…”
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p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis by Kirsch, David G, Santiago, Philip M, di Tomaso, Emmanuelle, Sullivan, Julie M, Hou, Wu-Shiun, Dayton, Talya, Jeffords, Laura B, Sodha, Pooja, Mercer, Kim L, Cohen, Rhianna, Takeuchi, Osamu, Korsmeyer, Stanley J, Bronson, Roderick T, Kim, Carla F, Haigis, Kevin M, Jain, Rakesh K, Jacks, Tyler

“…Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells…”
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Survival Factor-Induced Extracellular Signal-Regulated Kinase Phosphorylates BIM, Inhibiting Its Association with BAX and Proapoptotic Activity by Harada, Hisashi, Quearry, Bonnie, Ruiz-Vela, Antonio, Korsmeyer, Stanley J.

“…The "BH3-only" proapoptotic BCL-2 family members initiate the intrinsic apoptotic pathway. A small interfering RNA knockdown of BIM confirms this BH3-only…”
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Proapoptotic BAX and BAK Regulate the Type 1 Inositol Trisphosphate Receptor and Calcium Leak from the Endoplasmic Reticulum by Oakes, Scott A., Scorrano, Luca, Opferman, Joseph T., Bassik, Michael C., Nishino, Mari, Pozzan, Tullio, Korsmeyer, Stanley J.

“…Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and for maintaining the endoplasmic…”
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A Distinct Pathway Remodels Mitochondrial Cristae and Mobilizes Cytochrome c during Apoptosis by Scorrano, Luca, Ashiya, Mona, Buttle, Karolyn, Weiler, Solly, Oakes, Scott A., Mannella, Carmen A., Korsmeyer, Stanley J.

“…The mechanism during apoptosis by which cytochrome c is rapidly and completely released in the absence of mitochondrial swelling is uncertain. Here, we show…”
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Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions by Nam, Young-Jae, Mani, Kartik, Ashton, Anthony W., Peng, Chang-Fu, Krishnamurthy, Barath, Hayakawa, Yukihiro, Lee, Peiyee, Korsmeyer, Stanley J., Kitsis, Richard N.

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BCL-2, BCL-XL Sequester BH3 Domain-Only Molecules Preventing BAX- and BAK-Mediated Mitochondrial Apoptosis by Cheng, Emily H.-Y.A, Wei, Michael C, Weiler, Solly, Flavell, Richard A, Mak, Tak W, Lindsten, Tullia, Korsmeyer, Stanley J

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Multiple signaling pathways promote B lymphocyte stimulator–dependent B-cell growth and survival by Woodland, Robert T., Fox, Casey J., Schmidt, Madelyn R., Hammerman, Peter S., Opferman, Joseph T., Korsmeyer, Stanley J., Hilbert, David M., Thompson, Craig B.

“…We investigated the mechanism by which B lymphocyte stimulator (BLyS)/BAFF, a tumor necrosis factor superfamily ligand, promotes B-cell survival and resistance…”
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VDAC2 Inhibits BAK Activation and Mitochondrial Apoptosis by Emily H. -Y. Cheng, Sheiko, Tatiana V., Fisher, Jill K., Craigen, William J., Korsmeyer, Stanley J.

“…The multidomain proapoptotic molecules BAK or BAX are required to initiate the mitochondrial pathway of apoptosis. How cells maintain the potentially lethal…”
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A spatially and temporally restricted mouse model of soft tissue sarcoma by Jacks, Tyler, Kirsch, David G, Dinulescu, Daniela M, Miller, John B, Grimm, Jan, Santiago, Philip M, Young, Nathan P, Nielsen, G Petur, Quade, Bradley J, Chaber, Christopher J, Schultz, Christian P, Takeuchi, Osamu, Bronson, Roderick T, Crowley, Denise, Korsmeyer, Stanley J, Yoon, Sam S, Hornicek, Francis J, Weissleder, Ralph

“…Soft tissue sarcomas are mesenchymal tumors that are fatal in approximately one-third of patients. To explore mechanisms of sarcoma pathogenesis, we have…”
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