Search Results - "Korshunov, Andrey"

Sarcoma classification by DNA methylation profiling by Koelsche, Christian, Schrimpf, Daniel, Stichel, Damian, Sahm, Felix, Reuss, David E., Blattner, Mirjam, Worst, Barbara, Beck, Katja, Horak, Peter, Kreutzfeldt, Simon, Paff, Elke, Stark, Sebastian, Johann, Pascal, Selt, Florian, Sturm, Dominik, Pajtler, Kristian W., Reinhardt, Annekathrin, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail, Fernández-Klett, Francisco, Casalini, Belén, Korshunov, Andrey, Hovestadt, Volker, Kommoss, Felix K. F., Kriegsmann, Mark, Schick, Matthias, Bewerunge-Hudler, Melanie, Milde, Till, Witt, Olaf, Kulozik, Andreas E., Kool, Marcel, Romero-Pérez, Laura, Grünewald, Thomas G. P., Kirchner, Thomas, Wick, Wolfgang, Platten, Michael, Unterberg, Andreas, Uhl, Matthias, Debus, Jürgen, Lehner, Burkhard, Thomas, Christian, Hasselblatt, Martin, Paulus, Werner, Hartmann, Christian, Staszewski, Ori, Prinz, Marco, Hench, Jürgen, Frank, Stephan, Versleijen-Jonkers, Yvonne M. H., Weidema, Marije E., Griewank, Klaus, de Álava, Enrique, Martín, Juan Díaz, Gastearena, Miguel A. Idoate, Chang, Kenneth Tou-En, Low, Sharon Yin Yee, Cuevas-Bourdier, Adrian, Mittelbronn, Michel, Mynarek, Martin, Rutkowski, Stefan, Schüller, Ulrich, Mautner, Viktor F., Schittenhelm, Jens, Serrano, Jonathan, Snuderl, Matija, Büttner, Reinhard, Klingebiel, Thomas, Buslei, Rolf, Gessler, Manfred, Wesseling, Pieter, Dinjens, Winand N. M., Brandner, Sebastian, Jaunmuktane, Zane, Lyskjær, Iben, Schirmacher, Peter, Stenzinger, Albrecht, Brors, Benedikt, Glimm, Hanno, Tirado, Oscar M., Sáinz-Jaspeado, Miguel, Mora, Jaume, del Muro, Xavier Garcia, Moran, Sebastian, Esteller, Manel, Benhamida, Jamal K., Ladanyi, Marc, Wardelmann, Eva, Antonescu, Cristina, Flanagan, Adrienne, Dirksen, Uta, Hohenberger, Peter, Baumhoer, Daniel, Hartmann, Wolfgang, Flucke, Uta, Petersen, Iver, Mechtersheimer, Gunhild, Jones, David T. W., Fröhling, Stefan, von Deimling, Andreas

“…Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours…”
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ETMR: a tumor entity in its infancy by Lambo, Sander, von Hoff, Katja, Korshunov, Andrey, Pfister, Stefan M., Kool, Marcel

“…Embryonal tumor with Multilayered Rosettes (ETMR) is a relatively rare but typically deadly type of brain tumor that occurs mostly in infants. Since the…”
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Glioblastoma epigenome profiling identifies SOX10 as a master regulator of molecular tumour subtype by Wu, Yonghe, Fletcher, Michael, Gu, Zuguang, Wang, Qi, Costa, Barbara, Bertoni, Anna, Man, Ka-Hou, Schlotter, Magdalena, Felsberg, Jörg, Mangei, Jasmin, Barbus, Martje, Gaupel, Ann-Christin, Wang, Wei, Weiss, Tobias, Eils, Roland, Weller, Michael, Liu, Haikun, Reifenberger, Guido, Korshunov, Andrey, Angel, Peter, Lichter, Peter, Herrmann, Carl, Radlwimmer, Bernhard

“…Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal phenotypes with adverse prognosis. Here, we perform multi-omic profiling…”
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The Next Generation of Glioma Biomarkers: MGMT Methylation, BRAF Fusions and IDH1 Mutations by Von Deimling, Andreas, Korshunov, Andrey, Hartmann, Christian

“…For some, glioma biomarkers have been expected to solve common diagnostic problems in routine neuropathology service caused by insufficient material, technical…”
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Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
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Medulloblastoma Comprises Four Distinct Molecular Variants by NORTHCOTT, Paul A, KORSHUNOV, Andrey, RUTKA, James T, PFISTER, Stefan, TAYLOR, Michael D, WITT, Hendrik, HIELSCHER, Thomas, EBERHART, Charles G, MACK, Stephen, BOUFFET, Eric, CLIFFORD, Steven C, HAWKINS, Cynthia E, FRENCH, Pim

“…Recent genomic approaches have suggested the existence of multiple distinct subtypes of medulloblastoma. We studied a large cohort of medulloblastomas to…”
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Analysis of the IDH1 codon 132 mutation in brain tumors by Balss, Jörg, Meyer, Jochen, Mueller, Wolf, Korshunov, Andrey, Hartmann, Christian, von Deimling, Andreas

“…A recent study reported on mutations in the active site of the isocitrate dehydrogenase ( IDH1 ) gene in 12% of glioblastomas. All mutations detected resulted…”
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Second-generation molecular subgrouping of medulloblastoma: an international meta-analysis of Group 3 and Group 4 subtypes by Sharma, Tanvi, Schwalbe, Edward C., Williamson, Daniel, Sill, Martin, Hovestadt, Volker, Mynarek, Martin, Rutkowski, Stefan, Robinson, Giles W., Gajjar, Amar, Cavalli, Florence, Ramaswamy, Vijay, Taylor, Michael D., Lindsey, Janet C., Hill, Rebecca M., Jäger, Natalie, Korshunov, Andrey, Hicks, Debbie, Bailey, Simon, Kool, Marcel, Chavez, Lukas, Northcott, Paul A., Pfister, Stefan M., Clifford, Steven C.

“…In 2012, an international consensus paper reported that medulloblastoma comprises four molecular subgroups (WNT, SHH, Group 3, and Group 4), each associated…”
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CSF1R inhibition depletes tumor-associated macrophages and attenuates tumor progression in a mouse sonic Hedgehog-Medulloblastoma model by Tan, I-Li, Arifa, Raquel Duque Nascimento, Rallapalli, Harikrishna, Kana, Veronika, Lao, Zhimin, Sanghrajka, Reeti Mayur, Sumru Bayin, N., Tanne, Antoine, Wojcinski, Alexandre, Korshunov, Andrey, Bhardwaj, Nina, Merad, Miriam, Turnbull, Daniel H., Lafaille, Juan J., Joyner, Alexandra L.

“…The immune microenvironment of tumors can play a critical role in promoting or inhibiting tumor progression depending on the context. We present evidence that…”
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The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants by Pajtler, Kristian W., Mack, Stephen C., Ramaswamy, Vijay, Smith, Christian A., Witt, Hendrik, Smith, Amy, Hansford, Jordan R., von Hoff, Katja, Wright, Karen D., Hwang, Eugene, Frappaz, Didier, Kanemura, Yonehiro, Massimino, Maura, Faure-Conter, Cécile, Modena, Piergiorgio, Tabori, Uri, Warren, Katherine E., Holland, Eric C., Ichimura, Koichi, Giangaspero, Felice, Castel, David, von Deimling, Andreas, Kool, Marcel, Dirks, Peter B., Grundy, Richard G., Foreman, Nicholas K., Gajjar, Amar, Korshunov, Andrey, Finlay, Jonathan, Gilbertson, Richard J., Ellison, David W., Aldape, Kenneth D., Merchant, Thomas E., Bouffet, Eric, Pfister, Stefan M., Taylor, Michael D.

“…Multiple independent genomic profiling efforts have recently identified clinically and molecularly distinct subgroups of ependymoma arising from all three…”
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Analysis of BRAF V600E mutation in 1,320 nervous system tumors reveals high mutation frequencies in pleomorphic xanthoastrocytoma, ganglioglioma and extra-cerebellar pilocytic astrocytoma by Schindler, Genevieve, Capper, David, Meyer, Jochen, Janzarik, Wibke, Omran, Heymut, Herold-Mende, Christel, Schmieder, Kirsten, Wesseling, Pieter, Mawrin, Christian, Hasselblatt, Martin, Louis, David N., Korshunov, Andrey, Pfister, Stefan, Hartmann, Christian, Paulus, Werner, Reifenberger, Guido, von Deimling, Andreas

“…Missense mutations of the V600E type constitute the vast majority of tumor-associated somatic alterations in the v-RAF murine sarcoma viral oncogene homolog B1…”
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International Society of Neuropathology-Haarlem Consensus Guidelines for Nervous System Tumor Classification and Grading by Louis, David N., Perry, Arie, Burger, Peter, Ellison, David W., Reifenberger, Guido, von Deimling, Andreas, Aldape, Kenneth, Brat, Daniel, Collins, V. Peter, Eberhart, Charles, Figarella-Branger, Dominique, Fuller, Gregory N., Giangaspero, Felice, Giannini, Caterina, Hawkins, Cynthia, Kleihues, Paul, Korshunov, Andrey, Kros, Johan M., Beatriz Lopes, M., Ng, Ho-Keung, Ohgaki, Hiroko, Paulus, Werner, Pietsch, Torsten, Rosenblum, Marc, Rushing, Elisabeth, Soylemezoglu, Figen, Wiestler, Otmar, Wesseling, Pieter

“…Major discoveries in the biology of nervous system tumors have raised the question of how non‐histological data such as molecular information can be…”
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IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO by Reuss, David E., Mamatjan, Yasin, Schrimpf, Daniel, Capper, David, Hovestadt, Volker, Kratz, Annekathrin, Sahm, Felix, Koelsche, Christian, Korshunov, Andrey, Olar, Adriana, Hartmann, Christian, Reijneveld, Jaap C., Wesseling, Pieter, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Herold-Mende, Christel, Aldape, Kenneth, von Deimling, Andreas

“…The WHO 2007 classification of tumors of the CNS distinguishes between diffuse astrocytoma WHO grade II (A II WHO2007 ) and anaplastic astrocytoma WHO grade…”
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Immunohistochemical analysis of H3K27me3 demonstrates global reduction in group-A childhood posterior fossa ependymoma and is a powerful predictor of outcome by Panwalkar, Pooja, Clark, Jonathan, Ramaswamy, Vijay, Hawes, Debra, Yang, Fusheng, Dunham, Christopher, Yip, Stephen, Hukin, Juliette, Sun, Yilun, Schipper, Matthew J., Chavez, Lukas, Margol, Ashley, Pekmezci, Melike, Chung, Chan, Banda, Adam, Bayliss, Jill M., Curry, Sarah J., Santi, Mariarita, Rodriguez, Fausto J., Snuderl, Matija, Karajannis, Matthias A., Saratsis, Amanda M., Horbinski, Craig M., Carret, Anne-Sophie, Wilson, Beverly, Johnston, Donna, Lafay-Cousin, Lucie, Zelcer, Shayna, Eisenstat, David, Silva, Marianna, Scheinemann, Katrin, Jabado, Nada, McNeely, P. Daniel, Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Hawkins, Cynthia, Korshunov, Andrey, Judkins, Alexander R., Venneti, Sriram

“…Posterior fossa ependymomas (EPN_PF) in children comprise two morphologically identical, but biologically distinct tumor entities. Group-A (EPN_PFA) tumors…”
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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas by Khuong-Quang, Dong-Anh, Buczkowicz, Pawel, Rakopoulos, Patricia, Liu, Xiao-Yang, Fontebasso, Adam M., Bouffet, Eric, Bartels, Ute, Albrecht, Steffen, Schwartzentruber, Jeremy, Letourneau, Louis, Bourgey, Mathieu, Bourque, Guillaume, Montpetit, Alexandre, Bourret, Genevieve, Lepage, Pierre, Fleming, Adam, Lichter, Peter, Kool, Marcel, von Deimling, Andreas, Sturm, Dominik, Korshunov, Andrey, Faury, Damien, Jones, David T., Majewski, Jacek, Pfister, Stefan M., Jabado, Nada, Hawkins, Cynthia

“…Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated…”
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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis by Thompson, Eric M, MD, Hielscher, Thomas, MSc, Bouffet, Eric, Prof, Remke, Marc, MD, Luu, Betty, BSc, Gururangan, Sridharan, Prof, McLendon, Roger E, Prof, Bigner, Darell D, Prof, Lipp, Eric S, MD, Perreault, Sebastien, MD, Cho, Yoon-Jae, MD, Grant, Gerald, MD, Kim, Seung-Ki, Prof, Lee, Ji Yeoun, MD, Rao, Amulya A Nageswara, MD, Li, Kay Ka Wai, MD, Ng, Ho-Keung, Prof, Yao, Yu, MD, Kumabe, Toshihiro, MD, Tominaga, Teiji, Prof, Grajkowska, Wieslawa A, Prof, Perek-Polnik, Marta, Prof, Low, David C Y, MBBCh, Seow, Wan Tew, MBBS, Chang, Kenneth T E, MBBCh, Mora, Jaume, Prof, Pollack, Ian F, Prof, Hamilton, Ronald L, MD, Leary, Sarah, MD, Moore, Andrew S, PhD, Ingram, Wendy J, PhD, Hallahan, Andrew R, MBBS, Jouvet, Anne, MD, Fèvre-Montange, Michelle, PhD, Vasiljevic, Alexandre, MD, Faure-Conter, Cecile, MD, Shofuda, Tomoko, PhD, Hashimoto, Naoya, MD, Jabado, Nada, MD, Weil, Alexander G, MD, Gayden, Tenzin, PhD, Wataya, Takafumi, MD, Shalaby, Tarek, MD, Grotzer, Michael, Prof, Zitterbart, Karel, PhD, Sterba, Jaroslav, Prof, Kren, Leos, MD, Hortobágyi, Tibor, Prof, Klekner, Almos, PhD, László, Bognár, Prof, Pócza, Tímea, MSc, Hauser, Peter, MD, Schüller, Ulrich, MD, Jung, Shin, Prof, Jang, Woo-Youl, MD, French, Pim J, Prof, Kros, Johan M, Prof, van Veelen, Marie-Lise C, MD, Massimi, Luca, MD, Leonard, Jeffrey R, Prof, Rubin, Joshua B, MD, Vibhakar, Rajeev, MD, Chambless, Lola B, MD, Cooper, Michael K, MD, Thompson, Reid C, Prof, Carvalho, Alice, MD, Nunes, Sofia, MD, Pimentel, José, MD, Fan, Xing, MD, Lyden, David, Prof, Garzia, Livia, PhD, Shih, David J H, PhD, Kijima, Noriyuki, MD, Schneider, Christian, MD, Adamski, Jennifer, PhD, Northcott, Paul A, PhD, Kool, Marcel, PhD, Jones, David T W, PhD, Chan, Jennifer A, MD, Nikolic, Ana, MD, Garre, Maria Luisa, MD, Van Meir, Erwin G, Prof, Osuka, Satoru, MD, Olson, Jeffrey J, Prof, Jahangiri, Arman, BSc, Castro, Brandyn A, BSc, Gupta, Nalin, MD, Moxon-Emre, Iska, MSc, Mabbott, Donald J, PhD, Lassaletta, Alvaro, MD, Hawkins, Cynthia E, Prof, Tabori, Uri, MD, Drake, James, Prof, Kulkarni, Abhaya, Prof, Dirks, Peter, Prof, Rutka, James T, Prof, Pfister, Stefan M, Prof, Packer, Roger J, Prof, Ramaswamy, Vijay, MD, Taylor, Michael D, Dr Prof

“…Summary Background Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which…”
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A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
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Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
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Characterization of R132H Mutation-specific IDH1 Antibody Binding in Brain Tumors by Capper, David, Weißert, Susanne, Balss, Jörg, Habel, Antje, Meyer, Jochen, Jäger, Diana, Ackermann, Ulrike, Tessmer, Claudia, Korshunov, Andrey, Zentgraf, Hanswalter, Hartmann, Christian, Von Deimling, Andreas

“…Heterozygous point mutations of isocitrate dehydrogenase (IDH)1 codon 132 are frequent in grade II and III gliomas. Recently, we reported an antibody specific…”
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Formation of Cellular Concrete Structures Based on Waste Glass and Liquid Glass by Samchenko, Svetlana V., Korshunov, Andrey V.

“…The use of waste in the production of building materials is one of the possible ways to solve problems related to the sustainable management of non-degradable…”
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