Search Results - "Korotkov, Vadim S"

Oligosubstituted Pyrroles Directly from Substituted Methyl Isocyanides and Acetylenes by Lygin, Alexander V., Larionov, Oleg V., Korotkov, Vadim S., de Meijere, Armin

“…The formal cycloaddition of α‐metallated methyl isocyanides 1 onto the triple bond of electron‐deficient acetylenes 2 represents a direct and convenient…”
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The Mechanism of Caseinolytic Protease (ClpP) Inhibition by Gersch, Malte, Gut, Felix, Korotkov, Vadim S., Lehmann, Johannes, Böttcher, Thomas, Rusch, Marion, Hedberg, Christian, Waldmann, Herbert, Klebe, Gerhard, Sieber, Stephan A.

“…Catch me if you can: The ClpP protease mediates protein homeostasis and can be efficiently inhibited by β‐lactones. A combination of molecular docking,…”
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Synthesis and biological activity of optimized belactosin C congeners by Korotkov, Vadim S, Ludwig, Antje, Larionov, Oleg V, Lygin, Alexander V, Groll, Michael, de Meijere, Armin

“…Successful biochemical studies of the natural products belactosin A and C as well as their more stable acylated derivatives have proved them to be powerful…”
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A Whole Proteome Inventory of Background Photocrosslinker Binding by Kleiner, Philipp, Heydenreuter, Wolfgang, Stahl, Matthias, Korotkov, Vadim S., Sieber, Stephan A.

“…Affinity‐based protein profiling (AfBPP) is a widely applied method for the target identification of bioactive molecules. Probes containing photocrosslinkers,…”
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Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT‑1 Controlled Pathways by Gleissner, Carolin M.-L, Pyka, Carolin L, Heydenreuter, Wolfgang, Gronauer, Thomas F, Atzberger, Carina, Korotkov, Vadim S, Cheng, Weiting, Hacker, Stephan M, Vollmar, Angelika M, Braig, Simone, Sieber, Stephan A

“…The natural product neocarzilin A (NCA) was discovered decades ago, and despite its potent cytotoxic effects no mode of action studies have been performed up…”
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Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms by Le, Philipp, Kunold, Elena, Macsics, Robert, Rox, Katharina, Jennings, Megan C., Ugur, Ilke, Reinecke, Maria, Chaves-Moreno, Diego, Hackl, Mathias W., Fetzer, Christian, Mandl, Franziska A. M., Lehmann, Johannes, Korotkov, Vadim S., Hacker, Stephan M., Kuster, Bernhard, Antes, Iris, Pieper, Dietmar H., Rohde, Manfred, Wuest, William M., Medina, Eva, Sieber, Stephan A.

“…New drugs are desperately needed to combat methicillin-resistant Staphylococcus aureus (MRSA) infections. Here, we report screening commercial kinase…”
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Hydantoin analogs inhibit the fully assembled ClpXP protease without affecting the individual peptidase and chaperone domains by Fetzer, Christian, Korotkov, Vadim S, Sieber, Stephan A

“…Proteolysis mediated by ClpXP is a crucial cellular process linked to bacterial pathogenesis. The development of specific inhibitors has largely focused on…”
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A chemical compound inhibiting the Aha1–Hsp90 chaperone complex by Stiegler, Sandrine C., Rübbelke, Martin, Korotkov, Vadim S., Weiwad, Matthias, John, Christine, Fischer, Gunter, Sieber, Stephan A., Sattler, Michael, Buchner, Johannes

“…The eukaryotic Hsp90 chaperone machinery comprises many co-chaperones and regulates the conformation of hundreds of cytosolic client proteins. Therefore, it is…”
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Selective Activation of Human Caseinolytic Protease P (ClpP) by Stahl, Matthias, Korotkov, Vadim S., Balogh, Dóra, Kick, Leonhard M., Gersch, Malte, Pahl, Axel, Kielkowski, Pavel, Richter, Klaus, Schneider, Sabine, Sieber, Stephan A.

“…Caseinolytic protease P (ClpP) is the proteolytic component of the ClpXP protein degradation complex. Eukaryotic ClpP was recently found to act within the…”
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A Chemical Disruptor of the ClpX Chaperone Complex Attenuates the Virulence of Multidrug‐Resistant Staphylococcus aureus by Fetzer, Christian, Korotkov, Vadim S., Thänert, Robert, Lee, Kyu Myung, Neuenschwander, Martin, von Kries, Jens Peter, Medina, Eva, Sieber, Stephan A.

“…The Staphylococcus aureus ClpXP protease is an important regulator of cell homeostasis and virulence. We utilized a high‐throughput screen against the ClpXP…”
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Dual Inhibitor of Staphylococcus aureus Virulence and Biofilm Attenuates Expression of Major Toxins and Adhesins by Hofbauer, Barbara, Vomacka, Jan, Stahl, Matthias, Korotkov, Vadim S, Jennings, Megan C, Wuest, William M, Sieber, Stephan A

“…Staphylococcus aureus is a major bacterial pathogen that invades and damages host tissue by the expression of devastating toxins. We here performed a…”
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Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association by Pahl, Axel, Lakemeyer, Markus, Vielberg, Marie-Theres, Hackl, Mathias W., Vomacka, Jan, Korotkov, Vadim S., Stein, Martin L., Fetzer, Christian, Lorenz-Baath, Katrin, Richter, Klaus, Waldmann, Herbert, Groll, Michael, Sieber, Stephan A.

“…Caseinolytic protease P (ClpP) is an important regulator of Staphylococcus aureus pathogenesis. A high‐throughput screening for inhibitors of ClpP peptidase…”
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A Minimal β-Lactone Fragment for Selective β5c or β5i Proteasome Inhibitors by Groll, Michael, Korotkov, Vadim S., Huber, Eva M., de Meijere, Armin, Ludwig, Antje

“…Broad‐spectrum proteasome inhibitors are applied as anticancer drugs, whereas selective blockage of the immunoproteasome represents a promising therapeutic…”
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A Minimal [beta]-Lactone Fragment for Selective [beta]5c or [beta]5i Proteasome Inhibitors by Groll, Michael, Korotkov, Vadim S, Huber, Eva M, deMeijere, Armin, Ludwig, Antje

“…Broad-spectrum proteasome inhibitors are applied as anticancer drugs, whereas selective blockage of the immunoproteasome represents a promising therapeutic…”
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Development and characterization of improved β-lactone-based anti-virulence drugs targeting ClpP by Zeiler, Evelyn, Korotkov, Vadim S., Lorenz-Baath, Katrin, Böttcher, Thomas, Sieber, Stephan A.

“…Here, we report the synthesis and in depth characterization of a second generation β-lactone derived virulence inhibitors. Based on initial results that…”
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GaCl3-catalyzed insertion of diazene derivatives into the cyclopropane ring by KOROTKOV, Vadim S, LARIONOV, Oleg V, HOFMEISTER, Anja, MAGULL, Jorg, DE MEIJERE, Armin

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A β-Lactone-Based Antivirulence Drug Ameliorates Staphylococcus aureus Skin Infections in Mice by Weinandy, Franziska, Lorenz-Baath, Katrin, Korotkov, Vadim S., Böttcher, Thomas, Sethi, Shneh, Chakraborty, Trinad, Sieber, Stephan A.

“…Skin infections caused by Staphylococcus aureus are a major clinical concern, especially if they are caused by multi‐resistant strains. In these cases, a…”
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An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression by Vomacka, Jan, Korotkov, Vadim S., Bauer, Bianca, Weinandy, Franziska, Kunzmann, Martin H., Krysiak, Joanna, Baron, Oliver, Böttcher, Thomas, Lorenz-Baath, Katrin, Sieber, Stephan A.

“…Methicillin‐resistant Staphylococcus aureus (MRSA) causes severe infections with only few effective antibiotic therapies currently available. To approach this…”
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AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control by Gersch, Malte, Famulla, Kirsten, Dahmen, Maria, Göbl, Christoph, Malik, Imran, Richter, Klaus, Korotkov, Vadim S., Sass, Peter, Rübsamen-Schaeff, Helga, Madl, Tobias, Brötz-Oesterhelt, Heike, Sieber, Stephan A.

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Frontispiece: An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression by Vomacka, Jan, Korotkov, Vadim S., Bauer, Bianca, Weinandy, Franziska, Kunzmann, Martin H., Krysiak, Joanna, Baron, Oliver, Böttcher, Thomas, Lorenz-Baath, Katrin, Sieber, Stephan A.

“…Anti‐Virulence Strategy The agreement depicted in the figure is between humans, who, instead of killing bacterial cells, just reduce their arsenal of virulence…”
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