Search Results - "Koropatkin, Nicole"

Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease by Cockburn, Darrell W., Koropatkin, Nicole M.

“…Carbohydrates comprise a large fraction of the typical diet, yet humans are only able to directly process some types of starch and simple sugars. The remainder…”
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How glycan metabolism shapes the human gut microbiota by Koropatkin, Nicole M., Cameron, Elizabeth A., Martens, Eric C.

“…Key Points The degradation of complex carbohydrates (glycans and polysaccharides) is a major symbiotic function carried out by microorganisms that inhabit the…”
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A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility by Desai, Mahesh S., Seekatz, Anna M., Koropatkin, Nicole M., Kamada, Nobuhiko, Hickey, Christina A., Wolter, Mathis, Pudlo, Nicholas A., Kitamoto, Sho, Terrapon, Nicolas, Muller, Arnaud, Young, Vincent B., Henrissat, Bernard, Wilmes, Paul, Stappenbeck, Thaddeus S., Núñez, Gabriel, Martens, Eric C.

“…Despite the accepted health benefits of consuming dietary fiber, little is known about the mechanisms by which fiber deprivation impacts the gut microbiota and…”
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The Sus operon: a model system for starch uptake by the human gut Bacteroidetes by Foley, Matthew H., Cockburn, Darrell W., Koropatkin, Nicole M.

“…Resident bacteria in the densely populated human intestinal tract must efficiently compete for carbohydrate nutrition. The Bacteroidetes, a dominant bacterial…”
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Host glycan utilization within the Bacteroidetes Sus-like paradigm by Brown, Haley A, Koropatkin, Nicole M

“…Abstract The Bacteroidetes are numerically abundant Gram-negative organisms of the distal human gut with a greatly expanded capacity to degrade complex…”
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TonB‐dependent transporters in the Bacteroidetes: Unique domain structures and potential functions by Pollet, Rebecca M., Martin, Lauryn M., Koropatkin, Nicole M.

“…The human gut microbiota endows the host with a wealth of metabolic functions central to health, one of which is the degradation and fermentation of complex…”
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Starch Digestion by Gut Bacteria: Crowdsourcing for Carbs by Cerqueira, Filipe M., Photenhauer, Amanda L., Pollet, Rebecca M., Brown, Haley A., Koropatkin, Nicole M.

“…Starch is a polymer of glucose and is one of the most abundant carbohydrates in a Western diet. Resistant starch escapes digestion by host small intestinal…”
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Complex Glycan Catabolism by the Human Gut Microbiota: The Bacteroidetes Sus-like Paradigm by Martens, Eric C., Koropatkin, Nicole M., Smith, Thomas J., Gordon, Jeffrey I.

“…Trillions of microbes inhabit the distal gut of adult humans. They have evolved to compete efficiently for nutrients, including a wide array of chemically…”
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Degradation of complex arabinoxylans by human colonic Bacteroidetes by Pereira, Gabriel V., Abdel-Hamid, Ahmed M., Dutta, Soumajit, D’Alessandro-Gabazza, Corina N., Wefers, Daniel, Farris, Jacob A., Bajaj, Shiv, Wawrzak, Zdzislaw, Atomi, Haruyuki, Mackie, Roderick I., Gabazza, Esteban C., Shukla, Diwakar, Koropatkin, Nicole M., Cann, Isaac

“…Some Bacteroidetes and other human colonic bacteria can degrade arabinoxylans, common polysaccharides found in dietary fiber. Previous work has identified gene…”
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Novel carbohydrate binding modules in the surface anchored α‐amylase of Eubacterium rectale provide a molecular rationale for the range of starches used by this organism in the human gut by Cockburn, Darrell W., Suh, Carolyn, Medina, Krizia Perez, Duvall, Rebecca M., Wawrzak, Zdzislaw, Henrissat, Bernard, Koropatkin, Nicole M.

“…Summary Gut bacteria recognize accessible glycan substrates within a complex environment. Carbohydrate binding modules (CBMs) of cell surface glycoside…”
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BoGH13ASus from Bacteroides ovatus represents a novel α-amylase used for  Bacteroides starch breakdown in the human gut by Brown, Haley A., DeVeaux, Anna L., Juliano, Brock R., Photenhauer, Amanda L., Boulinguiez, Matthieu, Bornschein, Russell E., Wawrzak, Zdzislaw, Ruotolo, Brandon T., Terrapon, Nicolas, Koropatkin, Nicole M.

“…Members of the Bacteroidetes phylum in the human colon deploy an extensive number of proteins to capture and degrade polysaccharides. Operons devoted to glycan…”
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SusE facilitates starch uptake independent of starch binding in B. thetaiotaomicron by Foley, Matthew H., Martens, Eric C., Koropatkin, Nicole M.

“…Summary The Bacteroides thetaiotaomicron starch utilization system (Sus) is a model system for nutrient acquisition by gut Bacteroidetes, a dominant phylum of…”
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A discrete genetic locus confers xyloglucan metabolism in select human gut Bacteroidetes by Larsbrink, Johan, Rogers, Theresa E., Hemsworth, Glyn R., McKee, Lauren S., Tauzin, Alexandra S., Spadiut, Oliver, Klinter, Stefan, Pudlo, Nicholas A., Urs, Karthik, Koropatkin, Nicole M., Creagh, A. Louise, Haynes, Charles A., Kelly, Amelia G., Cederholm, Stefan Nilsson, Davies, Gideon J., Martens, Eric C., Brumer, Harry

“…A genetic locus from the gut symbiont Bacteroides ovatus is identified and described that encodes a cohort of enzymes and carbohydrate-binding proteins…”
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Ruminococcal cellulosome systems from rumen to human by Ben David, Yonit, Dassa, Bareket, Borovok, Ilya, Lamed, Raphael, Koropatkin, Nicole M., Martens, Eric C., White, Bryan A., Bernalier-Donadille, Annick, Duncan, Sylvia H., Flint, Harry J., Bayer, Edward A., Moraïs, Sarah

“…Summary A cellulolytic fiber‐degrading bacterium, Ruminococcus champanellensis, was isolated from human faecal samples, and its genome was recently sequenced…”
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Nutrient-dependent morphological variability of Bacteroides thetaiotaomicron by Rangarajan, Aathmaja Anandhi, Koropatkin, Nicole M, Biteen, Julie S

“…Unique morphologies can enable bacteria to survive in their native environment. Furthermore, many bacteria change their cell shape to adapt to different…”
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The Starch Utilization System Assembles around Stationary Starch-Binding Proteins by Tuson, Hannah H., Foley, Matthew H., Koropatkin, Nicole M., Biteen, Julie S.

“…Bacteroides thetaiotaomicron (Bt) is a prominent member of the human gut microbiota with an extensive capacity for glycan harvest. This bacterium expresses a…”
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Molecular details of a starch utilization pathway in the human gut symbiont Eubacterium rectale by Cockburn, Darrell W., Orlovsky, Nicole I., Foley, Matthew H., Kwiatkowski, Kurt J., Bahr, Constance M., Maynard, Mallory, Demeler, Borries, Koropatkin, Nicole M.

“…Summary Eubacterium rectale is a prominent human gut symbiont yet little is known about the molecular strategies this bacterium has developed to acquire…”
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Starch Catabolism by a Prominent Human Gut Symbiont Is Directed by the Recognition of Amylose Helices by Koropatkin, Nicole M., Martens, Eric C., Gordon, Jeffrey I., Smith, Thomas J.

“…The human gut microbiota performs functions that are not encoded in our Homo sapiens genome, including the processing of otherwise undigestible dietary…”
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Microbial transformation of the host glycobiome by Szymanski, Christine M, Koropatkin, Nicole M

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SusG: A Unique Cell-Membrane-Associated α-Amylase from a Prominent Human Gut Symbiont Targets Complex Starch Molecules by Koropatkin, Nicole M., Smith, Thomas J.

“…SusG is an α-amylase and part of a large protein complex on the outer surface of the bacterial cell and plays a major role in carbohydrate acquisition by the…”
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