Search Results - "Korobko, I V"

Interaction between MAK-V protein kinase and synaptopodin by Kalinichenko, S. V, Vikhreva, P. N, Korobko, I. V

“…MAK-V protein kinase (also known as HUNK) was discovered more than decade ago but its functions and molecular mechanisms of action still remain mostly unknown…”
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Designing Multipurpose Diagnostic Units on the Basis of AFE Interfaces by Korenevskiy, N. A., Milostnaya, N. A., Nikolaev, V. N., Podmasteryev, K. V., Dreyzin, V. E., Eremenko, V. T., Koskin, A. V., Korobko, V. I.

“…The use of AFE interfaces in medical diagnostic equipment, including multipurpose devices, is discussed…”
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Combination of ARE and HRE cis-Regulatory Elements Elevates the Activity of Tumor-Specific hTERT Promoter by Kalinichenko, S. V., Korobko, I. V., Shepelev, M. V.

“…Tumor-specific promoters and cis -regulatory genetic elements are used for transcriptional control of therapeutic transgene expression in cancer gene therapy…”
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Mutations in the Effector Domain of RhoV GTPase Impair Its Binding to Pak1 Protein Kinase by Korobko, I. V., Shepelev, M. V.

“…Atypical RhoV GTPase (Chp/Wrch-2) is a member of the human Rho GTPase family, which belongs to the superfamily of Ras-related small GTPases. The biological…”
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An Optimized Electroporation-Free Method for Generation of Recombinant Adenoviral Plasmids by Shepelev, M. V., Korobko, I. V.

“…Recombinant adenoviruses are widely used for delivery and expression of transgenes for therapeutic purposes and in fundamental research. AdEasy™ adenoviral…”
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Production of Recombinant Proteins in the Milk of Transgenic Animals: Current State and Prospects by Shepelev, M V, Kalinichenko, S V, Deykin, A V, Korobko, I V

“…The use of transgenic animals as bioreactors for the synthesis of the recombinant proteins secreted into milk is a current trend in the development of…”
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mTOR-dependent transcriptional repression of Pdcd4 tumor suppressor in lung cancer cells by Vikhreva, P.N., Shepelev, M.V., Korobko, I.V.

“…Programmed cell death 4 (Pdcd4) tumor suppressor is frequently lost in tumors of various origins including lung cancer, and its loss contributes to tumor…”
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Pak6 protein kinase is a novel effector of an atypical Rho family GTPase Chp/RhoV by Shepelev, M. V., Korobko, I. V.

“…Chp/RhoV is an atypical Rho GTPase whose functions are far from being fully understood. To date several effector proteins of Chp have been identified,…”
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Xenobiotic Response Elements (XREs) from Human CYP1A1 Gene Enhance the hTERT Promoter Activity by Shepelev, M. V., Kalinichenko, S. V., Saakian, E. K., Korobko, I. V.

“…A hybrid 6XRE–hTERT promoter consisting of the hTERT tumor-specific promoter and six copies of the XRE element from the CYP1A1 human gene promoter was created…”
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Pdcd4 tumor suppressor: Properties, functions, and possible applications in oncology by Vikhreva, P. N, Shepelev, M. V, Korobko, E. V, Korobko, I. V

“…The inactivation of tumor suppressors and activation of protooncogenes are critical events in malignant cell transformation and tumor progression. Pdcd4…”
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Human Antithrombin III Minigene with an Optimized Splicing Pattern by Shepelev, M. V., Saakian, E. K., Kalinichenko, S. V., Korobko, I. V.

“…Antithrombin III (AT3) belongs to the superfamily of serine protease inhibitors (serpins) and is a major anticoagulant in physiological conditions. Based on…”
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Insertion of Multiple Artificial Introns of Universal Design into CDNA during Minigene Construction Assures Correct Transgene Splicing by Shepelev, M. V., Tikhonov, M. V., Kalinichenko, S. V., Korobko, I. V.

“…The presence of introns is often required for efficient transgene expression. The use of full-length genes for transgenesis is associated with technical…”
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Insertion of Multiple Artificial Introns of Universal Design into cDNA during Minigene Construction Assures Correct Transgene Splicing by Shepelev, M V, Tikhonov, M V, Kalinichenko, S V, Korobko, I V

“…The presence of introns is often required for efficient transgene expression. The use of full-length genes for transgenesis is associated with technical…”
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Optimal artificial mini-introns for transgenic expression in the cells of mice and hamsters by Tikhonov, M. V., Maksimenko, O. G., Georgiev, P. G., Korobko, I. V.

“…Introns can frequently enhance transgene expression, and sometimes they are absolutely substantial. Based on an analysis of murine genes, in which mRNA does…”
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Neonatal Lethality and Inflammatory Phenotype of the New Transgenic Mice with Overexpression of Human Interleukin-6 in Myeloid Cells by Zvartsev, R. V., Korshunova, D. S., Gorshkova, E. A., Nosenko, M. A., Korneev, K. V., Maksimenko, O. G., Korobko, I. V., Kuprash, D. V., Drutskaya, M. S., Nedospasov, S. A., Deikin, A. V.

“…To model human interleukin-6 (hIL-6) associated diseases, unique mice with transgenic overexpression of human IL-6 and reporter fluorescent protein EGFP in…”
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A Novel Hybrid Promoter ARE-hTERT for Cancer Gene Therapy by Kalinichenko, S V, Shepelev, M V, Vikhreva, P N, Korobko, I V

“…describe a novel hybrid tumor-specific promoter, ARE-hTERT, composed of the human gene promoter (hTERT) and the antioxidant response element (ARE) from the…”
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GMOs in Russia: Research, Society and Legislation by Korobko, I V, Georgiev, P G, Skryabin, K G, Kirpichnikov, M P

“…Russian legislation lags behind the rapid developments witnessed in genetic engineering. Only a scientifically based and well-substantiated policy on the place…”
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Characterization of Rabaptin-5 γ isoform by Korobko, E. V., Kiselev, S. L., Korobko, I. V.

“…Rab GTPases are key regulators of intracellular membrane traffic acting through their effector molecules. Rabaptin-5 is a Rab5 effector in early endosome…”
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Enhanced Vector Design for Cancer Gene Therapy with Hierarchical Enhancement of Therapeutic Transgene Expression by Kostina, M B, Sass, A V, Stukacheva, E A, Korobko, I V, Sverdlov, E D

“…A set of vectors for Cre recombinase-dependent expression of the hybrid suicidal FCU1 transgene was constructed, including a two-plasmid system wherein the…”
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Selection of microRNA for providing tumor specificity of transgene expression in cancer gene therapy by Shepelev, M. V., Kalinichenko, S. V., Vikhreva, P. N., Korobko, I. V.

“…The use of tumor-specific microRNA loss to inhibit transgene expression in normal cells is considered as a way to increase the specificity of gene-therapeutic…”
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