Search Results - "Kornblum, H. I."

Analysis of Oncogenic Signaling Networks in Glioblastoma Identifies ASPM as a Molecular Target by Horvath, S., Zhang, B., Carlson, M., Lu, K. V., Zhu, S., Felciano, R. M., Laurance, M. F., Zhao, W., Qi, S., Chen, Z., Lee, Y., Scheck, A. C., Liau, L. M., Wu, H., Geschwind, D. H., Febbo, P. G., Kornblum, H. I., Cloughesy, T. F., Nelson, S. F., Mischel, P. S.

“…Glioblastoma is the most common primary malignant brain tumor of adults and one of the most lethal of all cancers. Patients with this disease have a median…”
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PBK/TOPK, a Proliferating Neural Progenitor-Specific Mitogen-Activated Protein Kinase Kinase by Dougherty, J. D, Garcia, A. D. R, Nakano, I, Livingstone, M, Norris, B, Polakiewicz, R, Wexler, E. M, Sofroniew, M. V, Kornblum, H. I, Geschwind, D. H

“…We performed genomic subtraction coupled to microarray-based gene expression profiling and identified the PDZ (postsynaptic density-95/Discs large/zona…”
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Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the Pten Tumor Suppressor Gene in Vivo by Groszer, Matthias, Erickson, Rebecca, Scripture-Adams, Deirdre D., Lesche, Ralf, Trumpp, Andreas, Zack, Jerome A., Kornblum, Harley I., Liu, Xin, Wu, Hong

“…The mechanisms controlling neural stem cell proliferation are poorly understood. Here we demonstrate that the PTEN tumor suppressor plays an important role in…”
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In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET) by Kornblum, Harley I, Araujo, Dalia M, Annala, Alexander J, Tatsukawa, Keith J, Phelps, Michael E, Cherry, Simon R

“…The study of neural repair and neuroplasticity in rodents would be enhanced by the ability to assess neuronal function in vivo. Positron emission tomography…”
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Interactive Regulation of Neuronal Development by Hippocampal Stem Cell Niche Populations by Le Belle, J.E., Kornblum, H.I.

“…Microenvironment cues and cell-to-cell interactions balance stem cell quiescence with proliferation and direct neurogenesis in the adult hippocampal niche…”
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Identification of a human glioma-associated growth factor gene, granulin, using differential immuno-absorption by LIAU, L. M, LALLONE, R. L, SEITZ, R. S, BUZNIKOV, A, GREGG, J. P, KORNBLUM, H. I, NELSON, S. F, BRONSTEIN, J. M

“…Identification of the genes that are differentially expressed in brain tumor cells but not in normal brain cells is important for understanding the molecular…”
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Cancerous Stem Cells Can Arise from Pediatric Brain Tumors by Hemmati, Houman D., Nakano, Ichiro, Lazareff, Jorge A., Masterman-Smith, Michael, Geschwind, Daniel H., Bronner-Fraser, Marianne, Kornblum, Harley I.

“…Pediatric brain tumors are significant causes of morbidity and mortality. It has been hypothesized that they derive from self-renewing multipotent neural stem…”
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Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway by Nakano, Ichiro, Joshi, Kaushal, Visnyei, Koppany, Hu, Bin, Watanabe, Momoko, Lam, Diana, Wexler, Eric, Saigusa, Kuniyasu, Nakamura, Yuko, Laks, Dan R., Mischel, Paul S., Viapiano, Mariano, Kornblum, Harley I.

“…Glioblastoma multiforme (GBM) is a devastating disease, and the current therapies have only palliative effect. Evidence is mounting to indicate that brain…”
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Developmental expression of OSP/claudin-11 by Bronstein, J.M., Chen, K., Tiwari-Woodruff, S., Kornblum, H.I.

“…Oligodendrocyte‐specific protein (OSP/claudin‐11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction…”
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The Predominant Neural Stem Cell Isolated from Postnatal and Adult Forebrain But Not Early Embryonic Forebrain Expresses GFAP by Imura, Tetsuya, Kornblum, Harley I, Sofroniew, Michael V

“…Periventricular germinal zones (GZs) of developing and adult brain contain neural stem cells (NSCs), the cellular identities and origins of which are not…”
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Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients by MATHERN, G. W, PRETORIUS, J. K, LEVESQUE, M. F, ADELSON, P. D, PEACOCK, W. J, KORNBLUM, H. I, MENDOZA, D, LOZADA, A, LEITE, J. P, CHIMELLI, L. M. C, FRIED, I, SAKAMOTO, A. C, ASSIRATI, J. A

“…This study was designed to determine whether hippocampal neuronal AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and NMDA…”
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Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients by Mathern, Gary W., Pretorius, James K., Mendoza, Delia, Leite, Joao P., Chimelli, Leila, Born, Donald E., Fried, Itzhak, Assirati, Joao A., Ojemann, George A., Adelson, P. David, Cahan, Leslie D., Kornblum, Harley I.

“…Changes in the subunit stoichiometry of the N‐methyl‐D‐aspartate (NMDA) receptor (NMDAR) alters its channel properties, and may enhance or reduce neuronal…”
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Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy by Mathern, Gary W, Pretorius, James K, Leite, Joao P, Kornblum, Harley I, Mendoza, Delia, Lozada, Alana, Bertram III, Edward H

“…This study compared temporal lobe epilepsy patients, along with kindled animals and self sustained limbic status epilepticus (SSLSE) rats for parallels in…”
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Electrical and optical monitoring of α-latrotoxin action at Drosophila neuromuscular junctions by Umbach, J.A, Grasso, A, Zurcher, S.D, Kornblum, H.I, Mastrogiacomo, A, Gundersen, C.B

“…Electrophysiological recording demonstrates that α-latrotoxin, a 125 000 mol. wt component of black widow spider venom, promotes high frequency quantal…”
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A subpopulation of striatal gabaergic neurons expresses the epidermal growth factor receptor by Kornblum, H.I., Gall, C.M., Seroogy, K.B., Lauterborn, J.C.

“…Epidermal growth factor and transforming growth factor alpha are mitogenic polypeptides that act at the epidermal growth factor receptor, a protein tyrosine…”
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From Hematopoiesis to Neuropoiesis: Evidence of Overlapping Genetic Programs by Terskikh, Alexey V., Easterday, Mathew C., Li, Linheng, Hood, Leroy, Kornblum, Harley I., Geschwind, Daniel H., Weissman, Irving L.

“…It is reasonable to propose that gene expression profiles of purified stem cells could give clues for the molecular mechanisms of stem cell behavior. We took…”
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Trophic Stimulation of Cultured Neurons from Neonatal Rat Brain by Epidermal Growth Factor by Morrison, Richard S., Kornblum, Harley I., Leslie, Frances M., Bradshaw, Ralph A.

“…Epidermal growth factor (EGF) is a potent polypeptide mitogen originally isolated from the adult male mouse submaxillary gland. It also acts as a…”
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A Genetic Analysis of Neural Progenitor Differentiation by Geschwind, Daniel H., Ou, Jing, Easterday, Mathew C., Dougherty, Joseph D., Jackson, Robert L., Chen, Zugen, Antoine, Heath, Terskikh, Alexey, Weissman, Irving L., Nelson, Stanley F., Kornblum, Harley I.

“…Genetic mechanisms regulating CNS progenitor function and differentiation are not well understood. We have used microarrays derived from a representational…”
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Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks by Karsten, Stanislav L, Kudo, Lili C, Jackson, Robert, Sabatti, Chiara, Kornblum, Harley I, Geschwind, Daniel H

“…The genetic programs underlying neural stem cell (NSC) proliferation and pluripotentiality have only been partially elucidated. We compared the gene expression…”
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Postnatal development of multiple opioid receptors in rat brain by Kornblum, H I, Hurlbut, D E, Leslie, F M

“…Recent studies have demonstrated that opioid receptors may be functional at early stages of ontogeny, and may modulate specific developmental functions. It is…”
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