Search Results - "Korn, Joseph"

Hydrogen-Rich Cation Radicals of DNA Dinucleotides: Generation and Structure Elucidation by UV–Vis Action Spectroscopy by Liu, Yang, Korn, Joseph A, Dang, Andy, Tureček, František

“…Hydrogen-rich DNA dinucleotide cation radicals (dGG + 2H)+•, (dCG + 2H)+•, and (dGC + 2H)+• represent transient species comprising protonated and hydrogen atom…”
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UV–Vis Photodissociation Action Spectroscopy on Thermo LTQ-XL ETD and Bruker amaZon Ion Trap Mass Spectrometers: a Practical Guide by Dang, Andy, Korn, Joseph A., Gladden, James, Mozzone, Brandon, Tureček, František

“…We report automated procedures for multiple tandem mass spectra acquisition allowing UV–Vis photodissociation action spectroscopy measurements of ions and…”
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Cytosine Radical Cations: A Gas‐Phase Study Combining IRMPD Spectroscopy, UVPD Spectroscopy, Ion–Molecule Reactions, and Theoretical Calculations by Lesslie, Michael, Lawler, John T., Dang, Andy, Korn, Joseph A., Bím, Daniel, Steinmetz, Vincent, Maître, Philippe, Tureček, Frantisek, Ryzhov, Victor

“…The radical cation of cytosine (Cyt.+) is generated by dissociative oxidation from a ternary CuII complex in the gas phase. The radical cation is characterized…”
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Bosentan treatment of digital ulcers related to systemic sclerosis: results from the RAPIDS-2 randomised, double-blind, placebo-controlled trial by Matucci-Cerinic, Marco, Denton, Christopher P, Furst, Daniel E, Mayes, Maureen D, Hsu, Vivien M, Carpentier, Patrick, Wigley, Fredrick M, Black, Carol M, Fessler, Barri J, Merkel, Peter A, Pope, Janet E, Sweiss, Nadera J, Doyle, Mittie K, Hellmich, Bernhard, Medsger, Jr, Thomas A, Morganti, Adele, Kramer, Fabrice, Korn, Joseph H, Seibold, James R

“…Ischaemic digital ulcers (DUs) are common in patients with systemic sclerosis (SSc) and are a cause of disease-related morbidity. In an earlier trial,…”
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UV–Vis Action Spectroscopy Reveals a Conformational Collapse in Hydrogen-Rich Dinucleotide Cation Radicals by Korn, Joseph A, Urban, Jan, Dang, Andy, Nguyen, Huong T. H, Tureček, František

“…We report the generation of deoxyriboadenosine dinucleotide cation radicals by gas-phase electron transfer to dinucleotide dications and their noncovalent…”
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Infrared and Electronic Spectroscopy of the Jet-Cooled 5‑Methyl-2-furanylmethyl Radical Derived from the Biofuel 2,5-Dimethylfuran by Kidwell, Nathanael M, Mehta-Hurt, Deepali N, Korn, Joseph A, Zwier, Timothy S

“…The electronic and infrared spectra of the 5-methyl-2-furanylmethyl (MFM) radical have been characterized under jet-cooled conditions in the gas phase. This…”
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Vibronic Spectroscopy of a Nitrile/Isonitrile Isoelectronic Pair: para-Diisocyanobenzene and para-Isocyanobenzonitrile by Mehta-Hurt, Deepali N, Korn, Joseph A, Gutberlet, Anna K, Zwier, Timothy S

“…The ultraviolet spectroscopy of isoelectronic pair para-diisocyanobenzene (pDIB) and para-isocyanobenzonitrile (pIBN) has been studied under gas-phase,…”
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Cartilage oligomeric matrix protein is overexpressed by scleroderma dermal fibroblasts by Farina, Giuseppina, Lemaire, Raphael, Korn, Joseph H., Widom, Russell L.

“…Cartilage oligomeric matrix protein (COMP) is an extracellular glycoprotein that belongs to the thrombospondin gene family. It is found predominantly in…”
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Responsiveness of the SF-36 and the Health Assessment Questionnaire Disability Index in a systemic sclerosis clinical trial by Dinesh Khanna, Daniel E Furst, Philip J Clements, Grace S Park, Ron D Hays, Jeonglim Yoon, Joseph H Korn, Peter A Merkel, Naomi Rothfield, Fredrick M Wigley, Larry W Moreland, Richard Silver, Virginia D Steen, Michael Weisman, Maureen D Mayes, David H Collier, Thomas A Medsger, Jr, James R Seibold, Relaxin Study Group, Scleroderma Clinical Trials Consortium

“…OBJECTIVE: This study compares the responsiveness to change of the Medical Outcomes Study Short Form Health Survey (SF-36), a measure of health related quality…”
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Human Collagen Krox Up-regulates Type I Collagen Expression in Normal and Scleroderma Fibroblasts through Interaction with Sp1 and Sp3 Transcription Factors by Kypriotou, Magdalini, Beauchef, Gallic, Chadjichristos, Christos, Widom, Russell, Renard, Emmanuelle, Jimenez, Sergio A., Korn, Joseph, Maquart, François-Xavier, Oddos, Thierry, Von Stetten, Otto, Pujol, Jean-Pierre, Galéra, Philippe

“…Despite several investigations, the transcriptional mechanisms that regulate the expression of both type I collagen genes (COL1A1 and COL1A2) in either…”
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Scleroderma Fibroblasts Demonstrate Enhanced Activation of Akt (Protein Kinase B) In Situ by Jun, Jae-Bum, Kuechle, Melanie, Min, Junki, Shim, Seung Cheol, Kim, Giok, Montenegro, Vivianne, Korn, Joseph H., Elkon, Keith B.

“…Recent studies suggest that, in addition to activation and hypersecretion of matrix components, fibroblasts from patients with systemic sclerosis (SSc) are…”
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Induction of heme oxygenase-1 by hypoxia and free radicals in human dermal fibroblasts by Panchenko, M V, Farber, H W, Korn, J H

“…Heme oxygenase-1 (HO-1) catalyzes the rate-limiting step in heme catabolism and presumably is involved in cellular iron homeostasis. It is induced by a variety…”
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Validity, reliability, and feasibility of durometer measurements of scleroderma skin disease in a multicenter treatment trial by Merkel, Peter A., Silliman, Nancy P., Denton, Christopher P., Furst, Daniel E., Khanna, Dinesh, Emery, Paul, Hsu, Vivien M., Streisand, James B., Polisson, Richard P., Åkesson, Anita, Coppock, John, van den Hoogen, Frank, Herrick, Ariane, Mayes, Maureen D., Veale, Douglas, Seibold, James R., Black, Carol M., Korn, Joseph H.

“…Objective To determine the validity, reliability, and feasibility of durometer measurements of skin hardness as an outcome measure in clinical trials of…”
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Durometry for the assessment of skin disease in systemic sclerosis by Kissin, Eugene Y., Schiller, Aileen M., Gelbard, Rondi B., Anderson, Jennifer J., Falanga, Vincent, Simms, Robert W., Korn, Joseph H., Merkel, Peter A.

“…Objective To examine the validity of a durometer to objectively measure skin hardness in systemic sclerosis (SSc), and to compare digital durometry with the…”
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Cytokine directed therapy in scleroderma: rationale, current status, and the future by Simms, Robert W, Korn, Joseph H

“…The hallmark of scleroderma is cutaneous and visceral fibrosis characterized in vivo and in vitro by increased biosynthesis of multiple matrix proteins by…”
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Fibulin-2 and Fibulin-5 Alterations in Tsk Mice Associated with Disorganized Hypodermal Elastic Fibers and Skin Tethering by Lemaire, Raphael, Korn, Joseph H., Schiemann, William P., Lafyatis, Robert

“…The Tight skin (Tsk) mouse is an important model of skin fibrosis that occurs in systemic sclerosis. These mice develop skin tethering and thickening…”
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Apoptosis and myofibroblasts in the pathogenesis of systemic sclerosis by Kissin, Eugene, Korn, Joseph H

“…Tissue fibrosis is the result of a complex series of events focusing on regulation of fibroblast proliferation, synthesis of extracellular matrix, and…”
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Fibrosis in scleroderma by Kissin, Eugene Y, Korn, Joseph H

“…The pathogenesis of fibrosis in scleroderma involves a complex set of interactions between the fibroblast and its surroundings. Multiple fibrotic pathways are…”
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Scleroderma: a treatable disease by Korn, Joseph H

“…Many effective treatments for scleroderma have emerged in recent years, including bosentan, an endothelin receptor antagonist, and epoprostenol, a…”
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Biology of the scleroderma fibroblast by Strehlow, D, Korn, J H

“…Abnormalities of matrix biosynthesis by systemic sclerosis fibroblasts underlie the cutaneous and visceral fibrosis seen in this disease. The fundamental basis…”
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