Differential impact of acute hypoxia on event related potentials: impaired task-irrelevant, but preserved task-relevant processing and response inhibition

The current study investigated how experimentally induced acute normobaric hypoxia affects attentional control functions during easy, monotonous visual sustained attention and response inhibition (modified Continuous Performance Task) and executive control tasks (number-size Stroop task). Along with...

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Bibliographic Details
Published in:	Physiology & behavior Vol. 206; pp. 28 - 36
Main Authors:	Altbäcker, Anna, Takács, Endre, Barkaszi, Irén, Kormos, Tamás, Czigler, István, Balázs, László
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-07-2019
Subjects:	Attentional control Event related potentials Normobaric hypoxia Novelty processing P300 Normobaric hypoxia Attentional control Novelty processing Event related potentials P300
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Summary:	The current study investigated how experimentally induced acute normobaric hypoxia affects attentional control functions during easy, monotonous visual sustained attention and response inhibition (modified Continuous Performance Task) and executive control tasks (number-size Stroop task). Along with behavioral efficiency, task-relevant and task-irrelevant information processing were investigated by measuring event related brain potentials (ERP) evoked by target stimuli (Target P3), task-relevant stimuli with no response needed (NoGo P3), and task-irrelevant novel stimuli (Novelty P3) during acute hypoxia exposure. Normobaric hypoxia was induced by adjusting the O2 content of the breathing mixture to obtain 80% peripheral oxygen saturation, equivalent of 5500 m above sea level. Here we report decreased Novelty P3 during acute normobaric hypoxia exposure, while Target P3 and NoGo P3, as well as behavioral efficiency remained intact. Our paper is the first to provide evidence for impaired novelty processing along with intact task-relevant information processing and response inhibition during normobaric hypoxic exposure. •Electrophysiological measures of attentional control were investigated during hypoxia.•Normobaric hypoxia impaired novelty processing indexed by Novelty P3.•Task performance was unaffected by hypoxia.•Response inhibition indexed by NoGo P3 also remained preserved.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-9384 1873-507X
DOI:	10.1016/j.physbeh.2019.03.022