Search Results - "Korkotian, Eduard"

Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases by Makarov, Mark, Korkotian, Eduard

“…Neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease, significantly reduce the quality of life of patients and eventually result in…”
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Roles of Calcium Stores and Store-Operated Channels in Plasticity of Dendritic Spines by Segal, Menahem, Korkotian, Eduard

“…Calcium stores in the endoplasmic reticulum play important roles in a variety of mammalian cellular functions. However, the multitude of calcium-handling…”
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Computational Modeling of Extrasynaptic NMDA Receptors: Insights into Dendritic Signal Amplification Mechanisms by Makarov, Mark, Papa, Michele, Korkotian, Eduard

“…Dendritic structures play a pivotal role in the computational processes occurring within neurons. Signal propagation along dendrites relies on both passive…”
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Synaptopodin regulates spine plasticity: mediation by calcium stores by Korkotian, Eduard, Frotscher, Michael, Segal, Menahem

“…The role of synaptopodin (SP), an actin-binding protein residing in dendritic spines, in synaptic plasticity was studied in dissociated cultures of hippocampus…”
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The role of the store‐operated calcium entry channel Orai1 in cultured rat hippocampal synapse formation and plasticity by Korkotian, Eduard, Oni‐Biton, Efrat, Segal, Menahem

“…Key points The role of non‐synaptic calcium entry in the formation and functions of dendritic spines was studied in dissociated cultured rat hippocampal…”
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Cultured Rat Hippocampal Neurons Exposed to the Mitochondrial Uncoupler Carbonyl Cyanide Chlorophenylhydrazone Undergo a Rapid, Presenilin-Dependent Change in Neuronal Properties by Kushnireva, Liliia, Segal, Menahem, Korkotian, Eduard

“…Presenilin 1 (PS1) is a transmembrane proteolytic subunit of -secretase that cleaves amyloid precursor proteins. Mutations in PS1 (mPS1) are associated with…”
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Exposure of Cultured Hippocampal Neurons to the Mitochondrial Uncoupler Carbonyl Cyanide Chlorophenylhydrazone Induces a Rapid Growth of Dendritic Processes by Kushnireva, Liliia, Korkotian, Eduard, Segal, Menahem

“…A major route for the influx of calcium ions into neurons uses the STIM-Orai1 voltage-independent channel. Once cytosolic calcium ([Ca2+]i) elevates, it…”
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Fast calcium transients in dendritic spines driven by extreme statistics by Basnayake, Kanishka, Mazaud, David, Bemelmans, Alexis, Rouach, Nathalie, Korkotian, Eduard, Holcman, David

“…Fast calcium transients (<10 ms) remain difficult to analyse in cellular microdomains, yet they can modulate key cellular events such as trafficking, local ATP…”
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Presenilins and mitochondria-an intriguing link: mini-review by Makarov, Mark, Kushnireva, Liliia, Papa, Michele, Korkotian, Eduard

“…This review uncovers the intricate relationship between presenilins, calcium, and mitochondria in the context of Alzheimer's disease (AD), with a particular…”
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Dynamic Regulation of Mitochondrial [Ca2+] in Hippocampal Neurons by Kushnireva, Liliya, Basnayake, Kanishka, Holcman, David, Segal, Menahem, Korkotian, Eduard

“…While neuronal mitochondria have been studied extensively in their role in health and disease, the rules that govern calcium regulation in mitochondria remain…”
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Correction: Fast calcium transients in dendritic spines driven by extreme statistics by Basnayake, Kanishka, Mazaud, David, Bemelmans, Alexis, Rouach, Nathalie, Korkotian, Eduard, Holcman, David

“…[This corrects the article DOI: 10.1371/journal.pbio.2006202.]…”
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Calcium Sensors STIM1 and STIM2 Regulate Different Calcium Functions in Cultured Hippocampal Neurons by Kushnireva, Liliya, Korkotian, Eduard, Segal, Menahem

“…There are growing indications for the involvement of calcium stores in the plastic properties of neurons and particularly in dendritic spines of central…”
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The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity by Segal, Menahem, Vlachos, Andreas, Korkotian, Eduard

“…The spine apparatus (SA) is an essential component of mature dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic…”
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Synaptopodin Regulates Plasticity of Dendritic Spines in Hippocampal Neurons by Vlachos, Andreas, Korkotian, Eduard, Schonfeld, Eldi, Copanaki, Ekaterini, Deller, Thomas, Segal, Menahem

“…The spine apparatus is an essential component of dendritic spines of cortical and hippocampal neurons, yet its functions are still enigmatic. Synaptopodin…”
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Barriers to diffusion in dendrites and estimation of calcium spread following synaptic inputs by Biess, Armin, Korkotian, Eduard, Holcman, David

“…The motion of ions, molecules or proteins in dendrites is restricted by cytoplasmic obstacles such as organelles, microtubules and actin network. To account…”
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Color-Coding Method Reveals Enhancement of Stereotypic Locomotion by Phenazepam in Rat Open Field Test by Makarov, Mark, Sysoev, Yuri I, Agafonova, Oksana, Prikhodko, Veronika A, Korkotian, Eduard, Okovityi, Sergey V

“…One of the most important tasks in neuroscience is the search for theoretical foundations for the development of methods for diagnosing and treating…”
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Ethanol affects network activity in cultured rat hippocampus: mediation by potassium channels by Korkotian, Eduard, Bombela, Tatyana, Odegova, Tatiana, Zubov, Petr, Segal, Menahem

“…The effects of ethanol on neuronal network activity were studied in dissociated cultures of rat hippocampus. Exposure to low (0.25-0.5%) ethanol concentrations…”
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Expression Profiling and Biochemical Analysis Suggest Stress Response as a Potential Mechanism Inhibiting Proliferation of Polyamine-depleted Cells by Landau, Guy, Ran, Avichai, Bercovich, Zippi, Feldmesser, Ester, Horn-Saban, Shirley, Korkotian, Eduard, Jacob-Hirsh, Jasmine, Rechavi, Gideon, Ron, David, Kahana, Chaim

“…Polyamines are small organic polycations that are absolutely required for cell growth and proliferation; yet the basis for this requirement is mostly unknown…”
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DP-b99 modulates matrix metalloproteinase activity and neuronal plasticity by Yeghiazaryan, Marine, Rutkowska-Wlodarczyk, Izabela, Konopka, Anna, Wilczyński, Grzegorz M, Melikyan, Armenuhi, Korkotian, Eduard, Kaczmarek, Leszek, Figiel, Izabela

“…DP-b99 is a membrane-activated chelator of zinc and calcium ions, recently proposed as a therapeutic agent. Matrix metalloproteinases (MMPs) are zinc-dependent…”
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Formation of dendritic spines in cultured striatal neurons depends on excitatory afferent activity by Segal, Menahem, Greenberger, Varda, Korkotian, Eduard

“…The role of afferent innervation in the formation of dendritic spines was studied in cultured rat striatum. The striatum is a unique structure in that it…”
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