Search Results - "Korkola, J. E."

Resistance to mammary tumorigenesis in Copenhagen rats is associated with the loss of preneoplastic lesions by KORKOLA, J. E, ARCHER, M. C

“…The resistance of Copenhagen (Cop) rats to mammary tumor development has recently been linked to three loci, but the genes have yet to be cloned and the…”
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In vivo differentiation and genomic evolution in adult male germ cell tumors by Korkola, J. E., Heck, S., Olshen, A. B., Reuter, V. E., Bosl, G. J., Houldsworth, J., Chaganti, R. S. K.

“…Germ cell tumors (GCTs) are the most common solid malignancy in young adult men, but the genes and genomic regions involved in their etiology are not fully…”
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Resistance to chemically-induced mammary tumors in copenhagen X nude-derived F2 athymic rats : evidence that T-cell immunity is not involved in Copenhagen resistance by KORKOLA, J. E, WOOD, G. A, ARCHER, M. C

“…Resistance to chemically-induced mammary tumors in the Copenhagen rat is well defined, but the mechanism of resistance has yet to be determined. We have tested…”
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Resistance of Copenhagen rats to hepatocarcinogenesis does not involve T-cell immunity by Wood, Geoffrey A., Korkola, James E., Archer, Michael C.

“…Previously, we have shown that Copenhagen (Cop) rats are highly resistant, compared with susceptible F344 rats, to the growth of glutathione S-transferase 7-7…”
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Resistance of Copenhagen rats to chemical induction of glutathione S-transferase 7-7-positive liver foci by WOOD, G. A, KORKOLA, J. E, LEE, V. M, SARMA, D. S. R, ARCHER, M. C

“…Copenhagen (Cop) rats are completely resistant to the chemical induction of mammary adenocarcinomas, but their susceptibility to hepatocarcinogenesis is…”
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Cyclin D1 expression during rat mammary tumor development and its potential role in the resistance of the Copenhagen rat by Korkola, J E, Wood, G A, Archer, M C

“…Resistance to mammary tumorigenesis in Copenhagen rats is associated with loss of early preneoplastic lesions known as intraductal proliferations. The cause of…”
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Abstract P3-03-04: Sensitivity to lapatinib differs between HER2-amplified breast cancer cells harboring kinase and helical domain mutations in PIK3CA and relies on production of PIP3 by Garay, JP, Korkola, JE, Gray, JW

“…Abstract Introduction: HER2 is amplified in nearly 25% of all primary breast cancers. Lapatinib is a targeted therapy that inhibits overactive HER2 signaling…”
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Abstract P6-08-01: A directed siRNA screen identifies INHBA as a major regulator of tumor aggressiveness in basal HER2 breast cancer by Korkola, JE, Liu, M, Smith, R, Liby, T, Heiser, L, Gray, JW

“…Abstract HER2+ breast cancers can be treated with several HER2-targeted inhibitors, but tumors often acquire or have de novo resistance to the therapies,…”
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Abstract PD5-01: Microenvironment microarrays show that microenvironment mediated resistance mechanisms to lapatinib differ between basal and luminal HER2+ cells by Korkola, JE, Watson, S, Smith, R, Thompson, W, Dame, M, Liby, T, Bucher, E, Sudar, D, Nederlof, M, Heiser, L, Gray, JW

“…Abstract Cell lines represent a valuable model system for the study of breast cancer, as they capture the cellular diversity, mutational spectrum, expression…”
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Down-regulation of stem cell genes, including those in a 200-kb gene cluster at 12p13.31, is associated with in vivo differentiation of human male germ cell tumors by KORKOLA, James E, HOULDSWORTH, Jane, CHADALAVADA, Rajendrakumar S. V, OLSHEN, Adam B, DOBRZYNSKI, Debbie, REUTER, Victor E, BOSI, George J, CHAGANTI, R. S. K

“…Adult male germ cell tumors (GCTs) comprise distinct groups: seminomas and nonseminomas, which include pluripotent embryonal carcinomas as well as other…”
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Bladder Cancer Outcome and Subtype Classification by Gene Expression by BLAVERI, Ekaterini, SIMKO, Jeff P, WALDMAN, Frederic M, KORKOLA, James E, BREWER, Jeremy L, BAEHNER, Frederick, MEHTA, Kshama, DEVRIES, Sandy, KOPPIE, Theresa, PEJAVAR, Sunanda, CARROLL, Peter

“…Models of bladder tumor progression have suggested that genetic alterations may determine both phenotype and clinical course. We have applied expression…”
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Array-based comparative genomic hybridization for genome-wide screening of DNA copy number in bladder tumors by VELTMAN, Joris A, FRIDLYAND, Jane, CORDON-CARDO, Carlos, JAIN, Ajay N, WALDMAN, Frederic M, PEJAVAR, Sunanda, OLSHEN, Adam B, KORKOLA, James E, DEVRIES, Sandy, CARROLL, Peter, KUO, Wen-Lin, PINKEL, Daniel, ALBERTSON, Donna

“…Genome-wide copy number profiles were characterized in 41 primary bladder tumors using array-based comparative genomic hybridization (array CGH). In addition…”
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Differentiation of lobular versus ductal breast carcinomas by expression microarray analysis by KORKOLA, James E, DEVRIES, Sandy, FRIDLYAND, Jane, HWANG, E. Shelley, ESTEP, Anne L. H, CHEN, Yunn-Yi, CHEW, Karen L, DAIRKEE, Shanaz H, JENSEN, Ronald M, WALDMAN, Frederic M

“…Invasive lobular and ductal breast tumors have distinct histologies and clinical presentation. Other than altered expression of E-cadherin, little is known…”
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Clonality of lobular carcinoma in situ and synchronous invasive lobular carcinoma by Shelley Hwang, E., Nyante, Sarah J., Yi Chen, Yunn, Moore, Dan, DeVries, Sandy, Korkola, James E., Esserman, Laura J., Waldman, Frederic M.

“…BACKGROUND Lobular carcinoma in situ (LCIS) of the breast is considered a marker for an increased risk of carcinoma in both breasts. However, the frequent…”
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P1-06-22: Identification of Biomarkers in Breast Cancer for Prediction of Response to PARP Inhibitor Olaparib by Daemen, A, Wolf, DM, Korkola, JE, Griffith, OL, Frankum, JR, Jakkula, LR, Wang, NJ, Natrajan, R, Reis-Filho, JS, Lord, CJ, Ashworth, A, Gray, JW, Spellman, PT, van't Veer, L

“…Abstract Background: Poly (ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. PARP inhibitors operate on the principle of synthetic lethality…”
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Gene expression-based classification of nonseminomatous male germ cell tumors by KORKOLA, James E, HOULDSWORTH, Jane, DOBRZYNSKI, Debbie, OLSHEN, Adam B, REUTER, Victor E, BOSL, George J, CHAGANTI, R. S. K

“…Male adult germ cell tumors (GCTs) comprise two major histologic groups: seminomas and nonseminomas. Nonseminomatous GCTs (NSGCTs) can be further divided into…”
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Tissue-specific resistance to cancer development in the rat: phenotypes of tumor-modifier genes by Wood, Geoffrey A., Korkola, James E., Archer, Michael C.

“…Resistance to carcinogenesis in the rat is both strain- and tissue-specific. The phenotypic characteristics of resistance in the mammary gland, liver and…”
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Cyclin D1 is necessary but not sufficient for anchorage-independent growth of rat mammary tumor cells and is associated with resistance of the Copenhagen rat to mammary carcinogenesis by LI, You-Jun, RUNLAN SONG, KORKOLA, James E, ARCHER, Michael C, BEN-DAVID, Yaacov

“…To identify genes associated with the resistance of Copenhagen (Cop) rats to mammary carcinogenesis, we infused a retrovirus harboring v-Ha-ras directly into…”
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Optimizing stringency for expression microarrays by Korkola, James E, Estep, Anne L, Pejavar, Sunanda, DeVries, Sandy, Jensen, Ronald, Waldman, Frederic M

“…While several studies have reported methods to optimize expression microarray protocols, none have dealt directly with hybridization wash stringency. We…”
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Transcriptional program associated with IFN-alpha response of renal cell carcinoma by Banerjee, Debendranath, Chadalavada, Rajendrakumar S V, Bourdon, Veronique, Korkola, James E, Motzer, Robert J, Chaganti, R S K

“…Metastatic renal cell carcinoma (RCC) is refractory to therapy; however, 10%-20% of patients respond favorably with interferon-alpha (IFN-alpha) treatment. To…”
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