Changes in serum levels of calcitonin gene‐related peptide, adiponectin, and ghrelin in pregnant women with gestational diabetes mellitus

Changes in serum levels of calcitonin gene‐related peptide, adiponectin, and ghrelin in pregnant women with gestational diabetes mellitus

Aim This study was designed to determine serum calcitonin gene‐related peptide (CGRP) levels and define whether serum CGRP concentration is associated with adiponectin and ghrelin in pregnant women with gestational diabetes mellitus (GDM). Study Design Thirty‐six pregnant women with GDM and 43 norma...

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Bibliographic Details
Published in:The journal of obstetrics and gynaecology research Vol. 47; no. 12; pp. 4171 - 4179
Main Authors: Koşar Can, Özlem, Cabuş, Ümit, Kabukcu, Cihan, Fenkci, Semin, Fenkci, Veysel, Enli, Yasar, Korkmaz, Berker
Format: Journal Article
Language:English
Published: Kyoto, Japan John Wiley & Sons Australia, Ltd 01-12-2021
Wiley Subscription Services, Inc
Subjects:
Adiponectin
Adiponectin - blood
Calcitonin
Calcitonin Gene-Related Peptide
Diabetes mellitus
Diabetes, Gestational
Female
Gestational diabetes
gestational diabetes mellitus
Ghrelin
Glucose tolerance
Humans
Intolerance
Peptides
Pregnancy
Serum levels
adiponectin
calcitonin gene-related peptide
ghrelin
gestational diabetes mellitus
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Summary:Aim This study was designed to determine serum calcitonin gene‐related peptide (CGRP) levels and define whether serum CGRP concentration is associated with adiponectin and ghrelin in pregnant women with gestational diabetes mellitus (GDM). Study Design Thirty‐six pregnant women with GDM and 43 normal pregnant women without glucose intolerance were evaluated in this study. The serum concentration of CGRP, adiponectin, and ghrelin were measured in two groups at the last trimester of gestation. Main Findings The serum CGRP level in the GDM group was significantly higher than the control group. Serum levels of adiponectin and ghrelin in the GDM group were significantly lower than in the control group. In pregnant women with GDM, there was a significant negative correlation between serum CGRP level and adiponectin level. However, the correlation between maternal serum CGRP levels and ghrelin levels was not significant. Conclusion Our investigation shows that serum CGRP level was significantly higher in pregnant women with GDM in comparison with the control group. These results suggest that CGRP may play a very important role in GDM pathogenesis.
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ISSN:1341-8076
1447-0756
DOI:10.1111/jog.15016