Search Results - "Korhonen, Ossi"

Continuous Pharmaceutical Manufacturing by Korhonen, Ossi

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Preservation of biomaterials and cells by freeze-drying: Change of paradigm by Merivaara, Arto, Zini, Jacopo, Koivunotko, Elle, Valkonen, Sami, Korhonen, Ossi, Fernandes, Francisco M., Yliperttula, Marjo

“…Freeze-drying is the most widespread method to preserve protein drugs and vaccines in a dry form facilitating their storage and transportation without the…”
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Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions by Löbmann, Korbinian, Strachan, Clare, Grohganz, Holger, Rades, Thomas, Korhonen, Ossi, Laitinen, Riikka

“…The co-amorphous simvastatin-glipizide (SVS-GPZ) molecular mixtures (molar ratios 2:1, 1:1 and 1:2), prepared by mechanical activation, showed no molecular…”
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The effect of light sensitizer localization on the stability of indocyanine green liposomes by Lajunen, Tatu, Nurmi, Riikka, Wilbie, Danny, Ruoslahti, Teemu, Johansson, Niklas G., Korhonen, Ossi, Rog, Tomasz, Bunker, Alex, Ruponen, Marika, Urtti, Arto

“…Light triggered drug delivery systems offer attractive possibilities for sophisticated therapy, providing both temporal and spatial control of drug release. We…”
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Predicting the Formation and Stability of Amorphous Small Molecule Binary Mixtures from Computationally Determined Flory−Huggins Interaction Parameter and Phase Diagram by Pajula, Katja, Taskinen, Markku, Lehto, Vesa-Pekka, Ketolainen, Jarkko, Korhonen, Ossi

“…The Flory−Huggins interaction parameter has been shown to be useful in predicting the thermodynamic miscibility of a polymer and a small molecule in a binary…”
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Comparison between integrated continuous direct compression line and batch processing – The effect of raw material properties by Karttunen, Anssi-Pekka, Wikström, Håkan, Tajarobi, Pirjo, Fransson, Magnus, Sparén, Anders, Marucci, Mariagrazia, Ketolainen, Jarkko, Folestad, Staffan, Korhonen, Ossi, Abrahmsén-Alami, Susanna

“…There is a current trend in pharmaceutical manufacturing to shift from traditional batch manufacture to continuous manufacturing. The purpose of this study was…”
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A Review of PAT Strategies in Secondary Solid Oral Dosage Manufacturing of Small Molecules by Laske, Stephan, Paudel, Amrit, Scheibelhofer, Otto

“…Pharmaceutical solid oral dosage product manufacturing is a well-established, yet revolutionizing area. To this end, process analytical technology (PAT)…”
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Surface Chemistry, Reactivity, and Pore Structure of Porous Silicon Oxidized by Various Methods by Riikonen, Joakim, Salomäki, Mikko, van Wonderen, Jessica, Kemell, Marianna, Xu, Wujun, Korhonen, Ossi, Ritala, Mikko, MacMillan, Fraser, Salonen, Jarno, Lehto, Vesa-Pekka

“…Oxidation is the most commonly used method of passivating porous silicon (PSi) surfaces against unwanted reactions with guest molecules and temporal changes…”
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In-Line Multipoint Near-Infrared Spectroscopy for Moisture Content Quantification during Freeze-Drying by Kauppinen, Ari, Toiviainen, Maunu, Korhonen, Ossi, Aaltonen, Jaakko, Järvinen, Kristiina, Paaso, Janne, Juuti, Mikko, Ketolainen, Jarkko

“…During the past decade, near-infrared (NIR) spectroscopy has been applied for in-line moisture content quantification during a freeze-drying process. However,…”
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Biopharmaceutics of Topical Ophthalmic Suspensions: Importance of Viscosity and Particle Size in Ocular Absorption of Indomethacin by Toropainen, Elisa, Fraser-Miller, Sara J, Novakovic, Dunja, Del Amo, Eva M, Vellonen, Kati-Sisko, Ruponen, Marika, Viitala, Tapani, Korhonen, Ossi, Auriola, Seppo, Hellinen, Laura, Reinisalo, Mika, Tengvall, Unni, Choi, Stephanie, Absar, Mohammad, Strachan, Clare, Urtti, Arto

“…Eye drops of poorly soluble drugs are frequently formulated as suspensions. Bioavailability of suspended drug depends on the retention and dissolution of drug…”
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The Comparison of Two Challenging Low Dose APIs in a Continuous Direct Compression Process by Ervasti, Tuomas, Niinikoski, Hannes, Mäki-Lohiluoma, Eero, Leppinen, Heidi, Ketolainen, Jarkko, Korhonen, Ossi, Lakio, Satu

“…Segregation is a common problem in batch-based direct compression (BDC) processes, especially with low-dose tablet products, as is the preparation of a…”
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Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems by Hakkarainen, Enni, Kõrkjas, Arle, Laidmäe, Ivo, Lust, Andres, Semjonov, Kristian, Kogermann, Karin, Nieminen, Heikki J., Salmi, Ari, Korhonen, Ossi, Haeggström, Edward, Heinämäki, Jyrki

“…We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and…”
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Evaluation of novel starch acetate–diltiazem controlled release tablets in healthy human volunteers by Korhonen, Ossi, Kanerva, Harri, Vidgren, Mika, Urtti, Arto, Ketolainen, Jarkko

“…Highly substituted starch acetate can be used to control drug release from directly compressed tablets in vitro. The aim of this study was to evaluate…”
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Rational excipient selection for co-amorphous formulations by Korhonen, Ossi, Pajula, Katja, Laitinen, Riikka

“…For almost two decades there has been intense debate about whether the amorphous solid state form could resolve the solubility problems and subsequent…”
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Production and stability of amorphous solid dispersions produced by a Freeze-drying method from DMSO by Valkama, Eetu, Haluska, Ondřej, Lehto, Vesa-Pekka, Korhonen, Ossi, Pajula, Katja

“…[Display omitted] Freeze drying is known to be able to produce an amorphous product, but this approach has been mostly used with water-based media. With APIs…”
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Converting a batch based high-shear granulation process to a continuous dry granulation process; a demonstration with ketoprofen tablets by Taipale-Kovalainen, Krista, Ketolainen, Jarkko, Korhonen, Ossi, Ervasti, Tuomas

“…When one wishes to convert a batch based manufacturing process of an existing tablet product to a continuous process, there are several available strategies…”
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Raman imaging of amorphous-amorphous phase separation in small molecule co-amorphous systems by Kilpeläinen, Tuomas, Pajula, Katja, Ervasti, Tuomas, Uurasjärvi, Emilia, Koistinen, Arto, Korhonen, Ossi

“…[Display omitted] Many new active pharmaceutical ingredients (API) undergoing development have low permeabilities or low aqueous solubilities. However, the…”
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Continuous manufacturing of tablets with PROMIS-line — Introduction and case studies from continuous feeding, blending and tableting by Simonaho, Simo-Pekka, Ketolainen, Jarkko, Ervasti, Tuomas, Toiviainen, Maunu, Korhonen, Ossi

“…Drug manufacturing technology is in the midst of modernization and continuous manufacturing of drug products is especially the focus of great interest. The…”
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Parameter optimization in a continuous direct compression process of commercially batch-produced bisoprolol tablets by Lyytikäinen, Jenna, Stasiak, Pawel, Kubelka, Tomáš, Olenius, Tino, Korhonen, Ossi, Ketolainen, Jarkko, Ervasti, Tuomas

“…[Display omitted] Continuous tablet manufacturing is a competitive option to replace the traditional batch manufacturing approach. The aim of this study was to…”
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Preparation and characterization of hot-melt extruded polycaprolactone-based filaments intended for 3D-printing of tablets by Viidik, Laura, Vesala, Jemina, Laitinen, Riikka, Korhonen, Ossi, Ketolainen, Jarkko, Aruväli, Jaan, Kirsimäe, Kalle, Kogermann, Karin, Heinämäki, Jyrki, Laidmäe, Ivo, Ervasti, Tuomas

“…•Arabic gum as plasticizer promotes the hot-melt extrusion of polycaprolactone-based filaments intended for 3D printing.•Inhomogeneity of a drug-polymer mass…”
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