Search Results - "Korfmacher, W A"

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species by VARTY, G. B, HYDE, L. A, XU, X, KORFMACHER, W. A, TULSHIAN, D, PARKER, E. M, HIGGINS, G. A, HODGSON, R. A, LU, S. X, MCCOOL, M. F, KAZDOBA, T. M, DEL VECCHIO, R. A, GUTHRIE, D. H, POND, A. J, GRZELAK, M. E

“…Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist,…”
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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice by MING LIU, BRYANT, M. S, DELL, J, SINHA, D, SYED, J, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, WANG, L, TAVERAS, A. G, DOLL, R. J, NJOROGE, F. G, JIANPING CHEN, MALLAMS, A. K, REMISZEWSKI, S, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, SUINING LEE, YAREMKO, B, LIPARI, P, MALKOWSKI, M, FERRARI, E, NIELSEN, L, PRIOLI, N

“…We have been developing a series of nonpeptidic, small molecule farnesyl protein transferase inhibitors that share a common tricyclic nucleus and compete with…”
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Systematic LC/MS metabolite identification in drug discovery by Clarke, N J, Rindgen, D, Korfmacher, W A, Cox, K A

“…Clarke et al present the choices and decisions involved in metabolite identification and how they can be merged into a systematic approach. The discussion…”
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Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry by Hsieh, Y, Brisson, J M, Ng, K, White, R E, Korfmacher, W A

“…A polymer-coated mixed-function (PCMF) column was evaluated for direct plasma injection for the simultaneous determination of a drug candidate and its hydroxyl…”
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Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry by Wu, Yunhui, Zhao, Jamie, Henion, Jack, Korfmacher, Walter A., Lapiguera, Amelia P., Lin, Chin-Chung

“…A sensitive and specific method was developed and validated to quantitate lovastatin and its hydroxy acid in mouse and rat plasma. This method employs a…”
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Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry by Bryant, Matthew S, Korfmacher, Walter A, Wang, Shiyong, Nardo, Cymbelene, Nomeir, Amin A, Lin, Chin-Chung

“…Selection of a new drug discovery candidate from a series of compounds requires a means of performing rapid analytical method development and sensitive…”
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Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry by Hsieh, Yunsheng, Chintala, Madhu, Mei, Hong, Agans, Jacqueline, Brisson, Jean-Marc, Ng, Kwokei, Korfmacher, Walter A.

“…A higher‐throughput bioanalytical method based on fast‐gradient (1 min run time) high‐performance liquid chromatography (HPLC) coupled with tandem mass…”
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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery by Korfmacher, Walter A., Cox, Kathleen A., Ng, Kwokei J., Veals, John, Hsieh, Yunsheng, Wainhaus, Sam, Broske, Lisa, Prelusky, Dan, Nomeir, Amin, White, Ronald E.

“…This report addresses the continuing need for increased throughput in the evaluation of new chemical entities (NCEs) in terms of their pharmacokinetic (PK)…”
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Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans by Hansen, Jr, E B, Cho, B P, Korfmacher, W A, Cerniglia, C E

“…1. Two strains of the filamentous fungus Cunninghamella elegans (ATCC 9245 and ATCC 36112) were screened for their ability to metabolize three alkylamine-type…”
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Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice by MING LIU, BRYANT, M. S, ROSSMAN, R. R, KORFMACHER, W. A, NOMEIR, A. A, LIN, C.-C, MALLAMS, A. K, DOLL, R. J, CATINO, J. J, GIRIJAVALLABHAN, V. M, KIRSCHMEIER, P, BISHOP, W. R, JIANPING CHEN, SUININHG LEE, YAREMKO, B, ZUJUN LI, DELL, J, LIPARI, P, MALKOWSKI, M, PRIOLI, N

“…The products of the Ha-, Ki-, and N-ras proto-oncogenes comprise a family of 21 kDa guanine nucleotide-binding proteins which play a crucial role in growth…”
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Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen by Getek, T A, Korfmacher, W A, McRae, T A, Hinson, J A

“…On-line formation and detection of glutathione and cysteine conjugates of acetaminophen were accomplished by the interfacing of a coulometric electrochemical…”
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DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene by Smith, B A, Korfmacher, W A, Beland, F A

“…Recent reports have indicated that 1-nitropyrene is tumorigenic in laboratory animals. Since it is generally accepted that the covalent binding of carcinogens…”
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Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites by Hansen, Jr, E B, Cerniglia, C E, Korfmacher, W A, Miller, D W, Heflich, R H

“…Fourteen fungi were found to metabolize pyrilamine (2-[(2-dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine). Two Cunninghamella elegans strains transformed…”
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Resistance to photochemical decomposition of polycyclic aromatic hydrocarbons vapor-adsorbed on coal fly ash by Korfmacher, W. A, Wehry, E. L, Mamantov, G, Natusch, D. F. S

“…Five polycyclic aromatic hydrocarbons-anthracene, benzo(A)pyrene, pyrene, fluoranthene, and phenanthrene-were adsorbed from the vapor phase onto coal flyash…”
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Combined capillary gas chromatography/atmospheric pressure negative chemical ionization/mass spectrometry for the determination of 2,3,7,8-tetrachlorodibenzo-p-dioxin in tissue by Mitchum, R. K, Moler, G. F, Korfmacher, W. A

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Plasma elimination and urinary excretion of methapyrilene in the rat by Kelly, D W, Holder, C L, Korfmacher, W A, Slikker, Jr, W

“…The metabolism and elimination of methapyrilene (2-[(2-dimethylaminoethyl)-2-thenylamino]pyridine) were characterized after the iv administration of 0.7 mg/kg…”
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Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations by JIWEN CHEN, KORFMACHER, Walter A, YUNSHENG HSIEH

“…The characterization of the drug metabolism and pharmacokinetic (DMPK) profiles of stereoisomers is a fundamental aspect of the drug discovery and development…”
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Fungal transformations of antihistamines: metabolism of cyproheptadine hydrochloride by Cunninghamella elegans by ZHANG, DONGLU, HANSEN, EUGENE B., DECK, JOANNA, HEINZE, THOMAS M., HENDERSON, ALLISON, KORFMACHER, WALTER A., CERNIGLIA, CARL E.

“…1. Metabolites formed during incubation of the antihistamine cyproheptadine hydrochloride with the zygomycete fungus Cunninghamella elegans in liquid culture…”
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Characterization of the mycotoxin fumonisin B1: comparison of thermospray, fast-atom bombardment and electrospray mass spectrometry by Korfmacher, W A, Chiarelli, M P, Lay, Jr, J O, Bloom, J, Holcomb, M, McManus, K T

“…The utility of thermospray mass spectrometry (TSMS), fast-atom bombardment mass spectrometry (FABMS), and electrospray mass spectrometry (ESMS) for the…”
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Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes by Kelly, D W, Holder, C L, Korfmacher, W A, Getek, T A, Lay, Jr, J O, Casciano, D A, Shaddock, J G, Duhart, H M, Slikker, Jr, W

“…1. Suspension cultures of freshly isolated F344 rat and B6C3F1 mouse hepatocytes were compared for their ability to transform various concentrations of…”
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