Search Results - "Korfhagen, Thomas"

Airway epithelial SPDEF integrates goblet cell differentiation and pulmonary Th2 inflammation by Rajavelu, Priya, Chen, Gang, Xu, Yan, Kitzmiller, Joseph A, Korfhagen, Thomas R, Whitsett, Jeffrey A

“…Epithelial cells that line the conducting airways provide the initial barrier and innate immune responses to the abundant particles, microbes, and allergens…”
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Endothelial immune activation programmes cell‐fate decisions and angiogenesis by inducing angiogenesis regulator DLL4 through TLR4‐ERK‐FOXC2 signalling by Xia, Sheng, Menden, Heather L., Korfhagen, Thomas R., Kume, Tsutomu, Sampath, Venkatesh

“…Key points The mechanisms by which bacteria alter endothelial cell phenotypes and programme inflammatory angiogenesis remain unclear. In lung endothelial…”
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SPDEF is required for mouse pulmonary goblet cell differentiation and regulates a network of genes associated with mucus production by Chen, Gang, Korfhagen, Thomas R, Xu, Yan, Kitzmiller, Joseph, Wert, Susan E, Maeda, Yutaka, Gregorieff, Alexander, Clevers, Hans, Whitsett, Jeffrey A

“…Various acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and…”
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Foxa3 Induces Goblet Cell Metaplasia and Inhibits Innate Antiviral Immunity by GANG CHEN, KORFHAGEN, Thomas R, SENFT, Albert P, WHITSETT, Jeffrey A, KARP, Christopher L, IMPEY, Soren, YAN XU, RANDELL, Scott H, KITZMILLER, Joseph, MAEDA, Yutaka, HAITCHI, Hans Michael, SRIDHARAN, Anusha

“…Goblet cell metaplasia accompanies common pulmonary disorders that are prone to recurrent viral infections. Mechanisms regulating both goblet cell metaplasia…”
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Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma by Le Cras, Timothy D, Acciani, Thomas H, Mushaben, Elizabeth M, Kramer, Elizabeth L, Pastura, Patricia A, Hardie, William D, Korfhagen, Thomas R, Sivaprasad, Umasundari, Ericksen, Mark, Gibson, Aaron M, Holtzman, Michael J, Whitsett, Jeffrey A, Hershey, Gurjit K Khurana

“…Increases in the epidermal growth factor receptor (EGFR) have been associated with the severity of airway thickening in chronic asthmatic subjects, and EGFR…”
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Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis by Madala, Satish K, Edukulla, Ramakrishna, Phatak, Mukta, Schmidt, Stephanie, Davidson, Cynthia, Acciani, Thomas H, Korfhagen, Thomas R, Medvedovic, Mario, Lecras, Timothy D, Wagner, Kimberly, Hardie, William D

“…Pulmonary fibrosis is often triggered by an epithelial injury resulting in the formation of fibrotic lesions in the lung, which progress to impair gas exchange…”
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SAM-pointed domain ETS factor mediates epithelial cell–intrinsic innate immune signaling during airway mucous metaplasia by Korfhagen, Thomas R, Kitzmiller, Joseph, Chen, Gang, Sridharan, Anusha, Haitchi, Hans-Michael, Hegde, Rashmi S, Divanovic, Senad, Karp, Christopher L, Whitsett, Jeffrey A

“…Airway mucus plays a critical role in clearing inhaled toxins, particles, and pathogens. Diverse toxic, inflammatory, and infectious insults induce airway…”
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SPDEF regulates goblet cell hyperplasia in the airway epithelium by Park, Kwon-Sik, Korfhagen, Thomas R, Bruno, Michael D, Kitzmiller, Joseph A, Wan, Huajing, Wert, Susan E, Khurana Hershey, Gurjit K, Chen, Gang, Whitsett, Jeffrey A

“…Goblet cell hyperplasia and mucous hypersecretion contribute to the pathogenesis of chronic pulmonary diseases including cystic fibrosis, asthma, and chronic…”
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Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis by Madala, Satish K, Korfhagen, Thomas R, Schmidt, Stephanie, Davidson, Cynthia, Edukulla, Ramakrishna, Ikegami, Machiko, Violette, Shelia M, Weinreb, Paul H, Sheppard, Dean, Hardie, William D

“…A number of growth factors and signaling pathways regulate matrix deposition and fibroblast proliferation in the lung. The epidermal growth factor receptor…”
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Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis by Korfhagen, Thomas R, Le Cras, Timothy D, Davidson, Cynthia R, Schmidt, Stephanie M, Ikegami, Machiko, Whitsett, Jeffrey A, Hardie, William D

“…Transforming growth factor (TGF)-alpha is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative…”
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Persistence of LPS-induced lung inflammation in surfactant protein-C-deficient mice by Glasser, Stephan W, Maxfield, Melissa D, Ruetschilling, Teah L, Akinbi, Henry T, Baatz, John E, Kitzmiller, Joseph A, Page, Kristen, Xu, Yan, Bao, Erik L, Korfhagen, Thomas R

“…Pulmonary surfactant protein-C (SP-C) gene-targeted mice (Sftpc(-/-)) develop progressive lung inflammation and remodeling. We hypothesized that SP-C…”
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Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis by Madala, Satish K, Edukulla, Ramakrishna, Davis, Katy R, Schmidt, Stephanie, Davidson, Cynthia, Kitzmiller, Joseph A, Hardie, William D, Korfhagen, Thomas R

“…Background Resistin-like molecule alpha or found in inflammatory zone protein (Fizz1) is increased in pulmonary epithelial cells and also in limited amounts by…”
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Signaling pathways in the epithelial origins of pulmonary fibrosis by Hardie, William D., Hagood, James S., Dave, Vrushank, Perl, Anne-Karina T., Whitsett, Jeffrey A., Korfhagen, Thomas R., Glasser, Stephan

“…Pulmonary fibrosis complicates a number of disease processes and leads to substantial morbidity and mortality. Idiopathic pulmonary fibrosis (IPF) is perhaps…”
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Wilms' tumor 1 drives fibroproliferation and myofibroblast transformation in severe fibrotic lung disease by Sontake, Vishwaraj, Kasam, Rajesh K, Sinner, Debora, Korfhagen, Thomas R, Reddy, Geereddy B, White, Eric S, Jegga, Anil G, Madala, Satish K

“…Wilms' tumor 1 (WT1) is a critical transcriptional regulator of mesothelial cells during lung development but is downregulated in postnatal stages and adult…”
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Acrolein-Activated Matrix Metalloproteinase 9 Contributes to Persistent Mucin Production by Deshmukh, Hitesh S, Shaver, Colleen, Case, Lisa M, Dietsch, Maggie, Wesselkamper, Scott C, Hardie, William D, Korfhagen, Thomas R, Corradi, Massimo, Nadel, Jay A, Borchers, Michael T, Leikauf, George D

“…Chronic obstructive pulmonary disease (COPD), a global public health problem, is characterized by progressive difficulty in breathing, with increased mucin…”
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Surfactant protein C-deficient mice are susceptible to respiratory syncytial virus infection by Glasser, Stephan W, Witt, Teah L, Senft, Albert P, Baatz, John E, Folger, Dusti, Maxfield, Melissa D, Akinbi, Henry T, Newton, Danforth A, Prows, Daniel R, Korfhagen, Thomas R

“…Patients with mutations in the pulmonary surfactant protein C (SP-C) gene develop interstitial lung disease and pulmonary exacerbations associated with viral…”
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Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies by Hassett, Daniel J, Korfhagen, Thomas R, Irvin, Randall T, Schurr, Michael J, Sauer, Karin, Lau, Gee W, Sutton, Mark D, Yu, Hongwei, Hoiby, Niels

“…CF airway mucus can be infected by opportunistic microorganisms, notably Pseudomonas aeruginosa. Once organisms are established as biofilms, even the most…”
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Inhibition of PI3K by PX-866 Prevents Transforming Growth Factor-α–Induced Pulmonary Fibrosis by Le Cras, Timothy D, Korfhagen, Thomas R, Davidson, Cynthia, Schmidt, Stephanie, Fenchel, Matthew, Ikegami, Machiko, Whitsett, Jeffrey A, Hardie, William D

“…Transforming growth factor-α (TGFα) is a ligand for the epidermal growth factor receptor (EGFR). EGFR activation is associated with fibroproliferative…”
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EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis by Hardie, William D, Davidson, Cynthia, Ikegami, Machiko, Leikauf, George D, Le Cras, Timothy D, Prestridge, Adrienne, Whitsett, Jeffrey A, Korfhagen, Thomas R

“…Transforming growth factor-alpha (TGF-alpha) is a ligand for the EGF receptor (EGFR). EGFR activation is associated with fibroproliferative processes in human…”
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Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury by Glasser, Stephan W, Senft, Albert P, Maxfield, Melissa D, Ruetschilling, Teah L, Baatz, John E, Page, Kristen, Korfhagen, Thomas R

“…Individuals with deficiencies of pulmonary surfactant protein C (SP-C) develop interstitial lung disease (ILD) that is exacerbated by viral infections…”
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