Search Results - "Koretzky, G. A."

The Adapter Protein SLP-76 Mediates “Outside-In” Integrin Signaling and Function in T Cells by Baker, R. G., Hsu, C. J., Lee, D., Jordan, M. S., Maltzman, J. S., Hammer, D. A., Baumgart, T., Koretzky, G. A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Coupling of the TCR to Integrin Activation by SLAP-130/Fyb by Peterson, Erik J., Woods, Melody L., Dmowski, Sally A., Derimanov, Geo, Jordan, Martha S., Wu, Jennifer N., Myung, Peggy S., Liu, Qing-Hua, Pribila, Jonathan T., Freedman, Bruce D., Shimizu, Yoji, Koretzky, Gary A.

“…SLAP-130/Fyb (SLP-76-associated phosphoprotein or Fyn-binding protein; also known as Fyb/Slap) is a hematopoietic-specific adapter, which associates with and…”
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Tyrosine Phosphatase CD45 is Required for T-Cell Antigen Receptor and CD2- Mediated Activation of a Protein Tyrosine Kinase and Interleukin 2 Production by Koretzky, Gary A., Picus, Joel, Schultz, Terrie, Weiss, Arthur

“…CD45, a hematopoietic cell-specific surface antigen, has recently been shown to be a protein tyrosine phosphatase. Expression of CD45 is essential for the…”
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CpG motifs in bacterial DNA trigger direct B-cell activation by Krieg, Arthur M, Yi, Ae-Kyung, Matson, Sara, Waldschmidt, Thomas J, Bishop, Gail A, Teasdale, Rebecca, Koretzky, Gary A, Klinman, Dennis M

“…Unmethylated CpG dinucleotides are more frequent in the genomes of bacteria and viruses than of vertebrates. We report here that bacterial DNA and synthetic…”
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Requirement for the Leukocyte-Specific Adapter Protein SLP-76 for Normal T Cell Development by Clements, James L., Yang, Baoli, Ross-Barta, Susan E., Eliason, Steve L., Hrstka, Ronald F., Williamson, Roger A., Koretzky, Gary A.

“…The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine…”
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Stimulatory effects of the protein tyrosine phosphatase inhibitor, pervanadate, on T-cell activation events by SECRIST, J. P, BURNS, L. A, KARNITZ, L, KORETZKY, G. A, ABRAHAM, R. T

“…Ligation of the multimeric T-cell antigen receptor complex (TCR) triggers a pleiotropic cellular activation response that includes lymphokine secretion,…”
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Fas Ligation Induces Apoptosis and Jun Kinase Activation Independently of CD45 and Lck in Human T Cells by Latinis, Kevin M., Koretzky, Gary A.

“…Stimulation through the Fas/APO-1 receptor results in apoptosis through an incompletely characterized signaling pathway. More is known regarding signal…”
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Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway by Koretzky, Gary A, Picus, Joel, Thomas, Matthew L, Weiss, Arthur

“…Stimulation of T lymphocytes through their antigen receptor (T-cell receptor; TCR) results in the activation of a tyrosine kinase and the generation of…”
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Coordination of receptor signaling in multiple hematopoietic cell lineages by the adaptor protein SLP-76 by Jordan, Martha S, Koretzky, Gary A

“…The adaptor protein SLP-76 is expressed in multiple hematopoietic lineages including T cells, platelets, and neutrophils. SLP-76 mediated signaling is…”
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Regulation of NKT cell development by SAP, the protein defective in XLP by Nichols, Kim E, Stein, Paul L, Hom, Jamie, Gong, Shun-You, Ganguly, Arupa, Ma, Cindy S, Cannons, Jennifer L, Tangye, Stuart G, Schwartzberg, Pamela L, Koretzky, Gary A

“…The adaptor molecule SAP is expressed in T lymphocytes and natural killer (NK) cells, where it regulates cytokine production and cytotoxicity. Here, we show…”
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The role of adapter proteins in T cell activation by Koretzky, G A, Boerth, N J

“…Engagement of antigen receptors on lymphocytes leads to a myriad of complex signal transduction cascades. Recently, work from several laboratories has led to…”
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Signal transduction in T lymphocytes by PETERSON, E. J, KORETZKY, G. A

“…T lymphocytes utilize a variety of surface receptors to transmit environmental signals across the plasma membrane and initiate biochemical events leading to…”
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Regulation of CD45 Engagement by the B-Cell Receptor CD22 by Sgroi, Dennis, Koretzky, Gary A., Stamenkovic, Ivan

“…The B-cell receptor CD22 binds sialic acid linked α-2-6 to terminal galactose residues on N-linked oligosaccharides associated with several cell-surface…”
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Adaptors as central mediators of signal transduction in immune cells by Koretzky, Gary A, Jordan, Martha S, Singer, Andrew L

“…Adaptors are molecular scaffolds that recruit effectors, which are critical for immune cell activation. Recent work has underscored the requirement for…”
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CD45-associated kinase activity requires lck but not T cell receptor expression in the Jurkat T cell line by KORETZKY, G. A, KOHMETSCHER, M, ROSS, S

“…The earliest biochemical event known to be associated with T cell receptor (TCR) engagement is the activation of a protein tyrosine kinase thought to be a…”
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Role of the CD45 tyrosine phosphatase in signal transduction in the immune system by Koretzky, G A

“…CD45, a family of hematopoietic cell specific surface antigens, is the best characterized protein tyrosine phosphatase described to date. Considerable evidence…”
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Regulation of Blood and Lymphatic Vascular Separation by Signaling Proteins SLP-76 and Syk by Abtahian, Farhad, Guerriero, Anastasia, Sebzda, Eric, Lu, Min-Min, Zhou, Rong, Mocsai, Attila, Myers, Erin E., Huang, Bin, Jackson, David G., Ferrari, Victor A., Tybulewicz, Victor, Lowell, Clifford A., Lepore, John J., Koretzky, Gary A., Kahn, Mark L.

“…Lymphatic vessels develop from specialized endothelial cells in preexisting blood vessels, but the molecular signals that regulate this separation are unknown…”
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SAP: natural inhibitor or grand SLAM of T cell activation? by Nichols, Kim E, Koretzky, Gary A, June, Carl H

“…Identification of SH2D1A as the defective gene in X-linked lymphoproliferative syndrome highlighted the importance of SAP in the regulation of T cell…”
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Regulation by CD45 of the tyrosine phosphorylation of high affinity IgE receptor beta- and gamma-chains by Adamczewski, M, Numerof, RP, Koretzky, GA, Kinet, JP

“…Previous studies using tyrosine phosphatase inhibitors have implicated tyrosine phosphatases in the signal transduction pathway initiated by aggregation of Fc…”
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Rescue of Signaling by a Chimeric Protein Containing the Cytoplasmic Domain of CD45 by Hovis, Robin R., Donovan, Jerald A., Musci, Michael A., Motto, David G., Goldman, Frederick D., Ross, Susan E., Koretzky, Gary A.

“…Surface expression of the CD45 tyrosine phosphatase is essential for the T cell antigen receptor (TCR) to couple optimally with its second messenger pathways…”
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